Anti-Protein bicaudal D homolog 2 BICD2 Antibody

Product Name

Anti-Protein bicaudal D homolog 2 BICD2 Antibody

View all BICD2 Antibodies

SKU/Catalog Number

A04406

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Protein bicaudal D homolog 2 BICD2 Antibody (Catalog # A04406). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

BICD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Protein bicaudal D homolog 2 BICD2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04406)

Host

Rabbit

Contents

BICD2 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

BICD2 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human BICD2. The immunogen is located within the last 50 amino acids of BICD2.

Cross-reactivity

This BICD2 antibody will not cross-react with BICD1.

Reactive Species

A04406 is reactive to BICD2 in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

93.5 kDa

Background of BICD2

BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A04406 is guaranteed for ELISA, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

BICD2 antibody can be used for detection of BICD2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information BICD2

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