|Ig Isotype||Mouse IgG1|
|Product Name||Anti-Spectrin(Alpha And Beta) Antibody (Monoclonal, SB-SP1)|
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Mouse IgG monoclonal antibody for Spectrin(alpha and beta), spectrin, alpha, erythrocytic 1 (elliptocytosis 2); spectrin, beta, erythrocytic (SPTA1; SPTB ) detection. Tested with WB in Human. No cross reactivity with other proteins.|
|Cite This Product||Anti-Spectrin(Alpha And Beta) Antibody (Monoclonal, SB-SP1) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1090)|
|Contents/Buffer||Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.|
|Immunogen||Human erythrocyte spectrin.|
Assay Dilutions Overview
Western blot, 2-4μg/ml, Human
Boster's Secondary Antibodies And IHC, WB Kits
The following reagents are used to generate the images below.Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot.
Images And Assay Conditions
Boster Kit Box
Protein Target Info (Source: Uniprot.org)
|Gene Name||SPTA1; SPTB|
|Protein Name||spectrin, alpha, erythrocytic 1(elliptocytosis 2); spectrin, beta, erythrocytic|
|Alternative Names||Erythroid spectrin beta ;Sptb ;LOC314251 ;|
|Subcellular Localization||SPTA1: Cytoplasm, cytoskeleton. Cytoplasm, cellcortex.|Spta1: Cytoplasm, cytoskeleton. Cytoplasm, cellcortex.|SPTB: Cytoplasm, cytoskeleton. Cytoplasm, cellcortex.|Sptb: Cytoplasm, cytoskeleton. Cytoplasm, cellcortex.|
|Molecular Weight||246329 MW|
*if product is indicated to react with multiple species, protein info is based on the human gene.
|Protein Function||SPTA1: Spectrin is the major constituent of the cytoskeletalnetwork underlying the erythrocyte plasma membrane. It associateswith band 4.1 and actin to form the cytoskeletal superstructure ofthe erythrocyte plasma membrane.|SPTB: Spectrin is the major constituent of the cytoskeletalnetwork underlying the erythrocyte plasma membrane. It associateswith band 4.1 and actin to form the cytoskeletal superstructure ofthe erythrocyte plasma membrane.|
|Research Areas||Actin Etc, Cytoskeleton, Cytoskeleton / Ecm, Microfilaments, Plasma Membrane, Signal Transduction, Subcellular Markers, Tags & Cell Markers
*You can search these to find other products in these research areas.
|Background||Spectrin, the predominant component of the membrane skeleton of the red cell, is essential in determining the properties of the membrane including its shape and deformability. It consists of 2 nonidentical subunits, alpha and beta. Spectrin is present in the red cell membrane in a tetrameric or possibly higher polymeric form through head-to-head self-association of heterodimers that are linked by actin polymers and protein 4.1 to form a 2-dimensional network. Non-erythroid spectrin gene is mapped to human chromosome 2. Spectrin mutations cause spinocerebellar ataxia type 5.|
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