SPTB Antibodies

AND SPTB ELISA kits, SPTB Proteins

Many biological assays use antibodies to detect SPTB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPTB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPTB antibodies...

We validate the specificity of these antibodies to SPTB by testing them on tissues known to express SPTB positively and negatively. Browse below to find the SPTB antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPTB Infographic by Boster Bio

All SPTB Products

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Anti-Spectrin(Alpha And Beta) SPTB Antibody (Monoclonal, SB-SP1)

Human

$370
Cat # MA1090
100 μg/vial

Anti-beta 1 Spectrin/SPTB Antibody Picoband®

Western blot analysis of beta 1 Spectrin/SPTB using anti-beta 1 Spectrin/SPTB antibody (A02392)

Flow Cytometry analysis of U937 cells using anti-beta 1 Spectrin/SPTB antibody (A02392)

Human, Mouse

ELISA, Flow Cytometry, WB

$370
Cat # A02392
100 µg/vial

SPTB Overview

Facts about Spectrin beta chain, erythrocytic.

SPTB 3D structure. Source: alphafold

Spectrin beta chain, erythrocytic (SPTB)

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.

1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. .

Gene Information

Human
Gene Name:	SPTB
Uniprot:	P11277
Entrez:	6710

Family

Belongs to:

spectrin family

Alternative Names

beta-I spectrin; EL3; erythrocyte; HS2; HSPTB1; membrane cytoskeletal protein; spectrin, beta, erythrocytic; SPTB1

Molecular Weight

Mass (kDA):
246.468 kDA

Genomic Context


Human

Location:	14q23.3
Sequence:	14; NC_000014.9 (64744106..64879907, complement)

Subcellular Localizations

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.

Diseases

Hereditary Spherocytosis
Premature Birth
Anemia
Elliptocytosis, Hereditary
Anemia, Hemolytic, Congenital
Premature Obstetric Labor
Hydrops Fetalis
Learning Disorders
Pregnancy Complications
Pregnancy Complications, Infectious
Hemolysis (disorder)

Neoplasms
Common Neoplasm
Hereditary Stomatocytosis
Uterine Fibroids
Hereditary Diseases
Hereditary Pyropoikilocytosis

Interacting Proteins

Csrp3
SNAPIN
SPTA1

Pathways

Pathogenesis
Transport
Methylation
Dna Methylation
Inflammatory Response
Erythrocyte Differentiation
Reverse Transcription
Mrna Splicing

Cell Morphogenesis
Localization

PTMs

Methylation

Research Areas

Cell Biology
Cellular Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPTB

References

PMID: 2195026 by Winkelmann J.C., et al. Full-length sequence of the cDNA for human erythroid beta-spectrin.

PMID: 2056132 by Garbarz M., et al. Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation.