Anti-TNF Receptor II/TNFRSF1B Antibody
Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 1B(TNFRSF1B) detection. Tested with WB, IHC-P in Human. Cited in 2 publication(s).
Anti-TNF Receptor II/TNFRSF1B Antibody Info At A Glance
|Product Name||Anti-TNF Receptor II/TNFRSF1B Antibody
See all TNF RII/TNFRSF1B primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for TNF RII/TNFRSF1B detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. TNF RII/TNFRSF1B information: Molecular Weight: 48291 MW; Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein.|
|Cite This Product||Anti-TNF Receptor II/TNFRSF1B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1243)|
|Similar Products From
|Anti-TNF Receptor II/TNFRSF1B Antibody may replace the following items: sc 1072|sc 1074|sc 393614|sc 4567|sc 7862|sc 8041.|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human TNF Receptor II(103-121aa DQVETQACTREQNRICTCR).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For TNFRSF1B (Source: Uniprot.org, NCBI)
|NCBI Gene Id||7133|
|Species Of This Entry||Human|
|Protein Name||Tumor necrosis factor receptor superfamily member 1B|
|Alternative Names||TNF RII/TNFRSF1B|CD120b antigen; CD120b; Etanercept; p75 TNF receptor; p75TBPII; p75TNFR; soluble TNFR1B variant 1; TNF RII; TNFBRp80 TNF-alpha receptor; TNF-R2; TNFR2TNFR1B; TNF-R75; TNFR80; TNFRII; TNF-RII; TNF-R-II; TNFR-II; TNFRSF1B; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II|
|Post Tranlational Modifications||Phosphorylation; Glycosylation; Cleavage|
|Subcellular Localization||[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Tumor necrosis factor-binding protein 2]: Secreted.|
|Gene Location||1p36.22, on Chromasome 1, gene sequence: NC_000001.11 (12166948..12209222)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For TNFRSF1B (Source: Uniprot.org, NCBI)
|Protein Function||Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.|
|Interacting Proteins||GRN; TNF; TRAF2|
|Related Diseases||Inflammation; Arthritis; Rheumatoid Arthritis; Malignant Neoplasms; Inflammatory Response; Dysequilibrium Syndrome; Hypertensive Disease; Neoplasms; Insulin Resistance; Autoimmune Diseases; Autoimmune Reaction; Familial Mediterranean Fever; Fracture; Diabetes Mellitus; Systemic Infection; Obesity; Carcinoma; Osteoporosis; Psoriasis|
|Related Pathways||Pathogenesis; Inflammatory Response; Immune Response; Cell Death; Angiogenesis; Secretion; Cytokine Production; Osteoclast Differentiation; Cell Proliferation; Response To Drug; Localization; Cell Adhesion; Cell Activation; Osteoclast Development; Aging; Glucose Homeostasis; Chemotaxis; Reverse Transcription; Mrna Transcription; Acute-phase Response|
|Background||Tumor necrosis factor receptor 2(TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors(TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12(12pter-cen) and 1(1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.|
|Scientific References||PMID: 2172983 by Kohno T., et al. A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.|
PMID: 2160731 by Smith C.A., et al. A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.
Our Boster Quality Guarantee for Anti-TNF Receptor II/TNFRSF1B Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: MM453 Cell Lysate
Lane 2: JURKAT Cell Lysate
IHC(P): Human Mammary Cancer Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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Total number of citations: 2
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Note: sample size takes longer to process, average 5-7 days.
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