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Product Info Summary
| SKU: | M03125 |
|---|---|
| Size: | 100 µl |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry, WB |
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Product info
Product Name
Anti-TNFRSF18 Mouse Monoclonal Antibody [Clone ID: OTI4A9]
View all GITR/TNFRSF18 Antibodies
SKU/Catalog Number
M03125
Size
100 µl
Description
Boster Bio TNFRSF18 mouse monoclonal antibody, clone OTI4A9 (formerly 4A9). Catalog# M03125. Tested in FC, WB. This antibody reacts with Human.
Storage & Handling
Store at -20°C as received.
Cite This Product
Anti-TNFRSF18 Mouse Monoclonal Antibody [Clone ID: OTI4A9] (Boster Biological Technology, Pleasanton CA, USA, Catalog # M03125)
Host
Mouse
Contents
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Clonality
Monoclonal
Clone Number
OTI4A9
Isotype
IgG1
Immunogen
Human recombinant protein fragment corresponding to amino acids 26-162 of human TNFRSF18 (NP_004186) produced in E.coli.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M03125 is reactive to TNFRSF18 in Human
Reconstitution
Calculated molecular weight
26kDa
Background of GITR/TNFRSF18
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. This gene is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M03125 is guaranteed for Flow Cytometry, WB Boster Guarantee
Validation Images & Assay Conditions
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Flow cytometric analysis of TNFRSF18 expression on living stimulated human peripheral blood mononuclear cells (PBMCs). Unstimulated PBMCs
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF18 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF18.
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Western blot analysis of human peripheral blood mononuclear cells (PBMCs) by using anti-TNFRSF18 monoclonal antibody. Left: Unstimulated PBMC. Right: PBMC stimulated with 10ug/ml Phytohemagglutinin for 3 days.
Protein Target Info & Infographic
Gene/Protein Information For TNFRSF18 (Source: Uniprot.org, NCBI)
Gene Name
TNFRSF18
Full Name
Tumor necrosis factor receptor superfamily member 18
Weight
26kDa
Alternative Names
Activation-inducible TNFR family receptor; AITR; AITRTNF receptor superfamily activation-inducible protein; CD357 antigen; CD357; GITR; GITR-D; GITRtumor necrosis factor receptor superfamily member 18; Glucocorticoid-induced TNFR-related protein; TNFRSF18; tumor necrosis factor receptor superfamily, member 18 TNFRSF18 AITR, CD357, ENERGEN, GITR, GITR-D TNF receptor superfamily member 18 tumor necrosis factor receptor superfamily member 18|TNF receptor superfamily activation-inducible protein|activation-inducible TNFR family receptor|glucocorticoid-induced TNFR-related protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TNFRSF18, check out the TNFRSF18 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TNFRSF18: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TNFRSF18 Mouse Monoclonal Antibody [Clone ID: OTI4A9] (M03125)
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