This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
ADAM10 Antibodies
AND ADAM10 ELISA kits, ADAM10 Proteins
Many biological assays use antibodies to detect ADAM10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADAM10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADAM10 antibodies...
Previous: A1BG
Next: ADARB1
ADAM10 Infographic by Boster Bio
All ADAM10 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M00566
100 μl
Cat # M00566
100 μl
ADAM10 Overview
Facts about Disintegrin and metalloproteinase domain-containing protein 10.
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
Cleaves the membrane-bound precursor of TNF-alpha at'76-Ala-
.Gene Information
| Human | |
|---|---|
| Gene Name: | ADAM10 |
| Uniprot: | O14672 |
| Entrez: | 102 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase domain 10; AD10; ADAM 10; ADAM metallopeptidase domain 10; ADAM10; CD156c antigen; CD156c; CDw156; disintegrin and metalloproteinase domain-containing protein 10; EC 3.4.24; HsT18717; kuz; Kuzbanian protein homolog; Kuzbanian; MADM; MADMEC 3.4.24.81; Mammalian disintegrin-metalloprotease
Molecular Weight
Mass (kDA):
84.142 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q21.3 |
| Sequence: | 15; NC_000015.10 (58588809..58749707, complement) |
Tissue Specificity
Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Cell projection, axon. Cell projection, dendrite. Cell junction, adherens junction. Cytoplasm. Is localized in the plasma membrane but is also expressed in the Golgi apparatus and in clathrin-coated vesicles derived likely from the Golgi (PubMed:12475894). During long term depression, it is recruited to the cell membrane by DLG1 (PubMed:23676497). The immature form is mainly located near cytoplasmic fibrillar structures, while the matu
Diseases
- Alzheimer's Disease
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Neuroblastoma
- Cell Invasion
- Neoplasm Metastasis
- Carcinoma
- Malignant Neoplasm Of Breast
- Nervousness
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- APP
- BACE1
- CD81
- CD9
- TSPAN12
- TSPAN14
- TSPAN15
- TSPAN33
- TSPAN5
Pathways
- Proteolysis
- Pathogenesis
- Cell Adhesion
- Secretion
- Cell Migration
- Localization
- Cell Growth
- Cell Proliferation
- Cell-cell Adhesion
- Rna Interference
- Protein Processing
- Angiogenesis
- Transport
PTMs
- Cleavage
- Phosphorylation
- Reduction
- Glycosylation
- Biotinylation
- Deacetylation
Research Areas
- Apoptosis
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADAM10
bosterbio.com/bosterbio-gene-info-cards/ADAM10
References
PMID: 9305925 by Rosendahl M.S., et al. Identification and characterization of a pro-tumor necrosis factor- alpha-processing enzyme from the ADAM family of zinc metalloproteases.
PMID: 8694785 by Howard L., et al. Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types.
1 Publications of Boster ADAM10 Antibodies & ELISA Kits
- PubMed ID: 27602753, Gemcitabine inhibits immune escape of pancreatic cancer by down regulating the s...
*More publications can be found for each product on its corresponding product page