Adhesion G protein-coupled receptor A2 (ADGRA2)

Endothelial receptor that functions together with RECK to allow brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a crucial role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity).

Acts as a Wnt7-specific coactivator of canonical Wnt signaling: needed to deliver RECK-bound Wnt7 to frizzled by assembling a higher- order RECK-ADGRA2-Fzd-LRP5-LRP6 complicated (PubMed:30026314). ADGRA2- tethering function doesn't rely on its own G-protein coupled receptor (GPCR) structure but rather on its combined capability to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314).