- Table of Content
Acts as a Wnt7-specific coactivator of canonical Wnt signaling: needed to deliver RECK-bound Wnt7 to frizzled by assembling a higher- order RECK-ADGRA2-Fzd-LRP5-LRP6 complicated (PubMed:30026314). ADGRA2- tethering function doesn't rely on its own G-protein coupled receptor (GPCR) structure but rather on its combined capability to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314).
|G-protein coupled receptor 2 family|
|Sequence:||8; NC_000008.11 (37796883..37844896)|
Expressed in endothelial cells (at protein level) (PubMed:15021905, PubMed:16982628). Abundantly expressed in heart, placenta, ovary, small intestine, and colon (PubMed:15021905).
Cell membrane; Multi-pass membrane protein. Cell projection, filopodium. Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact.