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The activation of MUSK in myotubes induces the formation of NMJ by regulating different procedures including the transcription of certain genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximum AChR clustering.
|Location:||4 E2|4 88.55 cM|
Expressed in central nervous system (CNS) synapses such as in the cerebral cortex and hippocampus. Localizes to basal lamina of hippocampal blood vessels. Both (z+) and (z-) isoforms found in kidney, heart and cerebral vasculature.