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- Table of Contents
Facts about Hydroperoxide isomerase ALOXE3.
In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. From the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl- sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a vital step in the conjugation of omega-hydroxyceramide to membrane proteins.
Mouse | |
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Gene Name: | Aloxe3 |
Uniprot: | Q9WV07 |
Entrez: | 23801 |
Belongs to: |
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lipoxygenase family |
arachidonate lipoxygenase 3; EC 1.13.11.-; E-LOX; eLOX3; e-LOX-3; epidermal lipoxygenase; epidermis-type lipoxygenase 3; MGC119694; MGC119695; MGC119696
Mass (kDA):
80.473 kDA
Mouse | |
---|---|
Location: | 11 B3|11 42.38 cM |
Sequence: | 11; |
Skin specific.
PMID: 10366447 by Kinzig A., et al. cDNA cloning, genomic structure and chromosomal localization of a novel epidermis-type lipoxygenase.
PMID: 17045234 by Yu Z., et al. Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.