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ANKRD28 Antibodies
AND ANKRD28 ELISA kits, ANKRD28 Proteins
Many biological assays use antibodies to detect ANKRD28, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ANKRD28 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ANKRD28 antibodies...
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ANKRD28 Overview
Facts about Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A.
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28)
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.
Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | ANKRD28 |
| Uniprot: | O15084 |
| Entrez: | 23243 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ankyrin repeat domain 28; Ankyrin repeat domain-containing protein 28; KIAA0379PITKPP6-ARS-Aphosphatase interactor targeting K protein; Phosphatase interactor targeting protein hnRNP K; protein phosphatase 6 ankyrin repeat subunit A; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A; Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A
Molecular Weight
Mass (kDA):
112.966 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p25.1 |
| Sequence: | 3; NC_000003.12 (15667236..15859814, complement) |
Subcellular Localizations
Nucleus, nucleoplasm. Seems to be excluded from nucleoli.
Diseases
- Protrusion
- Tissue Adhesions
- Leukemia, Myelocytic, Acute
- Malignant Neoplasms
- Myeloid Leukemia
- Leukemia
- Adenocarcinoma
- Leukemogenesis
- Neoplasm Metastasis
- Malignant Squamous Cell Neoplasm
- Hematologic Neoplasms
- Cebpa Gene Mutation
- Non-small Cell Lung Carcinoma
Interacting Proteins
- DOCK1
- PPP6C
- PPP6R1
- PPP6R2
- PPP6R3
- TNKS2
Pathways
- Localization
- Cell Migration
- Cell Adhesion
- Methylation
- Osteoclast Differentiation
- Hyperphosphorylation
- Cell Growth
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANKRD28
bosterbio.com/bosterbio-gene-info-cards/ANKRD28
References
PMID: 16564677 by Kwiek N.C., et al. PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K.
PMID: 18186651 by Stefansson B., et al. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains.