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CBX6 Antibodies
AND CBX6 ELISA kits, CBX6 Proteins
Many biological assays use antibodies to detect CBX6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CBX6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CBX6 antibodies...
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CBX6 Infographic by Boster Bio
All CBX6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1662
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1662
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A11651-2
100 μg/vial
Cat # A11651-2
100 μg/vial
CBX6 Overview
Facts about Chromobox protein homolog 6.
Chromobox protein homolog 6 (CBX6)
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to keep the transcriptionally repressive state of several genes, such as Hox genes, throughout evolution (PubMed:21282530). PcG PRC1 complex acts through chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A'Lys-119', rendering chromatin heritably changed in its expressibility.
Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might happen in an H3K27me3-independent fashion (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | CBX6 |
| Uniprot: | O95503 |
| Entrez: | 23466 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
chromobox homolog 6; chromobox protein homolog 6
Molecular Weight
Mass (kDA):
43.898 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.1 |
| Sequence: | 22; NC_000022.11 (38861422..38872216, complement) |
Subcellular Localizations
Nucleus. Chromosome. Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity).
Diseases
- Malignant Neoplasms
- Bladder Neoplasm
- Age Related Macular Degeneration
- Alzheimer's Disease
- Glaucoma
- Malignant Neoplasm Of Urinary Bladder
Interacting Proteins
- BMI1
- MOV10
- PCGF2
- PCGF3
- RING1
- RNF2
Pathways
- Cell Cycle
- Localization
- Protein Targeting
- Metaphase
- Regulation Of Gene Expression
- Nuclear Export
- Liver Development
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CBX6
bosterbio.com/bosterbio-gene-info-cards/CBX6
References
PMID: 18927235 by Vincenz C., et al. Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences.
PMID: 21282530 by Vandamme J., et al. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells.