Cyclin-dependent kinase 14 (CDK14)

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Referred to as a cell-cycle regulator of Wnt signaling pathway through G2/M phase by mediating the phosphorylation of LRP6 at'Ser-1490', leading to the activation of the Wnt signaling pathway.

Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of these result remains to be verified in vivo.