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Does not bind G- actin and promote actin polymerization by itself. Required for the formation of coordinated podosome rosettes.
|Location:||11 A1|11 3.87 cM|
Detected in hippocampus neurons and in the Purkinje cell layer in cerebellum (at protein level). Predominantly expressed in brain, thymus and spleen. Also found in testis, heart and lung. Little or no expression detected in ovary or muscle.