HPR Antibodies

AND HPR ELISA kits, HPR Proteins

Many biological assays use antibodies to detect HPR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HPR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HPR antibodies...

We validate the specificity of these antibodies to HPR by testing them on tissues known to express HPR positively and negatively. Browse below to find the HPR antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HPR Infographic by Boster Bio

All HPR Products

Product

Figures

Specificity

Applications

Price

Human HPR Recombinant Protein

SDS-PAGE

$250
Cat # PROTP00739
Starting from 10ug

Anti-HPR Rabbit Polyclonal Antibody

Human

$477
Cat # A02115
100 µl

HPR (NM_020995) Human Over-expression Lysate

Human

$628
Cat # LS003250
100 µg

HPR Overview

Facts about Haptoglobin-related protein.

HPR 3D structure. Source: alphafold

Haptoglobin-related protein (HPR)

Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-comprising high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF- 1), mediates human innate immune protection against several species of African trypanosomes.

Binds hemoglobin with high affinity and may contribute to the lack of cell-free hemoglobin to allow hepatic recycling of heme iron. .

Gene Information

Human
Gene Name:	HPR
Uniprot:	P00739
Entrez:	3250

Family

Belongs to:

peptidase S1 family

Alternative Names

A-259H10.2; Haptoglobin-Related Locus; Haptoglobin-Related Protein; HP

Molecular Weight

Mass (kDA):
39.03 kDA

Genomic Context


Human

Location:	16q22.2
Sequence:	16; NC_000016.10 (72063226..72077246)

Tissue Specificity

In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines.

Subcellular Localizations

Secreted. Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL).

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Myocardial Infarction
Coronary Artery Disease
Diabetes Mellitus
Infarction
Mammary Neoplasms
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Breast
Anemia
Acute Coronary Syndrome
Thrombosis

Orthomyxoviridae Infections
Hypoxia
Hemorrhage
Carcinogenesis
Neuroblastoma
African Trypanosomiasis
Fish Diseases

Pathways

Platelet Aggregation
Localization
Cell Death
Transport
Sporulation
Cell Cycle
Secretion
Photorespiration
Induction Of Apoptosis
Cell Growth
Cell Proliferation
Vasoconstriction
Endocytosis

Pathogenesis
Excretion
Virulence
Dna Repair
Dna Replication
Programmed Cell Death
Translation

PTMs

Phosphorylation
Oxidation
Cleavage
Reduction

Hydroxylation
Amidation
Glycosylation
Amination

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HPR

References

PMID: 4018023 by Bensi G., et al. Structure and expression of the human haptoglobin locus.

PMID: 2987228 by Maeda N.; Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element.