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KCNAB1 Antibodies
AND KCNAB1 ELISA kits, KCNAB1 Proteins
Many biological assays use antibodies to detect KCNAB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNAB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNAB1 antibodies...
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KCNAB1 Infographic by Boster Bio
All KCNAB1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M06063-2
100 µl
Cat # M06063-2
100 µl
Human, Mouse, Rat
IHC, WB
$523
Cat # M06063-1
100 µl
Cat # M06063-1
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M06063
100 µl
Cat # M06063
100 µl
KCNAB1 Overview
Facts about Voltage-gated potassium channel subunit beta-1.
Voltage-gated potassium channel subunit beta-1 (KCNAB1)
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity).
Promotes expression of the pore-forming alpha subunits in the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain name and increases the speed of channel closure for other family members (PubMed:9763623).
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNAB1 |
| Uniprot: | Q14722 |
| Entrez: | 7881 |
Family
| Belongs to: |
|---|
| shaker potassium channel beta subunit family |
Alternative Names
AKR6A3; hKvb3; hKvBeta3; K(+) channel subunit beta-1; KCNA1Bpotassium channel beta 3 chain; Kvb1.3; KV-BETA-1; potassium channel beta3 subunit; potassium channel shaker chain beta 1a; potassium voltage-gated channel beta subunit; potassium voltage-gated channel, shaker-related subfamily, beta member 1; voltage-gated potassium channel beta-1 subunit; voltage-gated potassium channel subunit beta-1
Molecular Weight
Mass (kDA):
46.563 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q25.31 |
| Sequence: | 3; NC_000003.12 (156118216..156542648) |
Tissue Specificity
In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.
Subcellular Localizations
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits.
Diseases
- Nervousness
- Epilepsy
- Learning Disorders
- Lateral Temporal Epilepsy
- Epilepsy, Temporal Lobe
- Schizophrenia
- Hypertensive Disease
- Cardiac Death
- Disease Of Adrenal Medulla
- Cardiac Arrhythmia
- Idiopathic Pulmonary Hypertension
- Hypoxia
- Cardiac Complication
Pathways
- Localization
- Cell Adhesion
- Transport
- Aging
- Neurogenesis
- Inflammatory Response
- Mrna Splicing
- Coagulation
- Translation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNAB1
bosterbio.com/bosterbio-gene-info-cards/KCNAB1
References
PMID: 7499366 by England S.K., et al. A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing.
PMID: 7890032 by Majumder K., et al. Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium.