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- Table of Contents
Menin Antibodies
AND MEN1 ELISA kits, Menin Proteins
Many biological assays use antibodies to detect Menin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Menin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Menin antibodies...
Designing a Western blot for Menin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MEN1 Western Blot GuideDesigning an IHC experiment for Menin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MEN1 IHC GuideMEN1 Infographic by Boster Bio
All MEN1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # A00334-2
100 μg/vial
Cat # A00334-2
100 μg/vial
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # A00331-1
100 μg/vial
Cat # A00331-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PA1864
100 μg/vial
Cat # PA1864
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01009
100 μg/vial
Cat # A01009
100 μg/vial
Human, Mouse
ELISA
$540
Cat # EKC2119
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2119
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1517
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1517
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M08183-1
100 μg
Cat # M08183-1
100 μg
MEN1 Overview
Facts about Menin.
Menin (MEN1)
Essential element of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator.
Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | MEN1 |
| Uniprot: | O00255 |
| Entrez: | 4221 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
MEAI; MEN1; Menin; multiple endocrine neoplasia I; multiple
Molecular Weight
Mass (kDA):
68.023 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.1 |
| Sequence: | 11; NC_000011.10 (64803514..64811294, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
Diseases
- Multiple Endocrine Neoplasia Type 1
- Neoplasms
- Multiple Endocrine Neoplasia
- Endocrine Gland Neoplasms
- Pituitary Diseases
- Adenoma
- Malignant Neoplasms
- Pancreatic Neoplasm
- Cell Transformation, Neoplastic
- Pituitary Neoplasms
- Hyperparathyroidism, Primary
- Parathyroid Neoplasms
Interacting Proteins
- CHEK1
- FANCD2
- JUND
- KMT2A
- MYH9
- NFKB1
- NFKB2
- Nme1
- RELA
Pathways
- Pathogenesis
- Localization
- Angiogenesis
- Cell Proliferation
- Secretion
- Cell Cycle
- Methylation
- Cell Growth
- Translation
- Oncogenesis
- Cell Differentiation
- Hormone Secretion
- S Phase
PTMs
- Methylation
- Phosphorylation
- Cleavage
- Acetylation
Research Areas
- Cancer
- DNA Repair
- Transcription Factors and Regulators
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MEN1
bosterbio.com/bosterbio-gene-info-cards/MEN1
References
PMID: 9103196 by Chandrasekharappa S.C., et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1.
PMID: 17555499 by Toledo R.A., et al. Novel MEN1 germline mutations in Brazilian families with multiple endocrine neoplasia type 1.
1 Publications of Boster Menin Antibodies & ELISA Kits
- PubMed ID: 10.1007/s10571-017-0481-5, High Expression of Pirh2 is Associated with Poor Prognosis in Glioma
*More publications can be found for each product on its corresponding product page