This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
OAS1 Antibodies
AND OAS1 ELISA kits, OAS1 Proteins
Many biological assays use antibodies to detect OAS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OAS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OAS1 antibodies...
Designing a Western blot for OAS1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the OAS1 Western Blot GuideDesigning an IHC experiment for OAS1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the OAS1 IHC GuideOAS1 Infographic by Boster Bio
All OAS1 Products
Product
Figures
Specificity
Applications
Price
OAS1 Overview
Facts about 2'-5'-oligoadenylate synthase 1.
2'-5'-oligoadenylate synthase 1 (OAS1)
Interferon-induced, dsRNA-activated antiviral receptor that plays a vital role in cellular innate antiviral response. Additionally, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation.
Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L contributes to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication.
Gene Information
| Human | |
|---|---|
| Gene Name: | OAS1 |
| Uniprot: | P00973 |
| Entrez: | 4938 |
Family
| Belongs to: |
|---|
| 2-5A synthase family |
Alternative Names
(2-5')oligo(A) synthase 1,2'-5'-oligoadenylate synthetase 1,2-5A synthase 1,2'-5'-oligoisoadenylate synthetase 1; (2-5')oligo(A) synthetase 1; 2'-5'-oligo A synthetase 1; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthetase 1 (40-46 kD); 2'-5'-oligoadenylate synthetase 1, 40/46kDa; E18/E16,2-5A synthetase 1; EC 2.7.7; EC 2.7.7.-; IFI-4,2'-5' oligoadenylate synthetase 1 p52 isoform; OIAS2'-5' oligoadenylate synthetase 1 p48 isoform; OIASI; p46/p42 OAS
Molecular Weight
Mass (kDA):
46.029 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.13 |
| Sequence: | 12; NC_000012.12 (112906777..112933219) |
Subcellular Localizations
Cytoplasm. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Secreted. Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
Diseases
- Virus Diseases
- Hepatitis
- Hepatitis C
- Infective Disorder
- Hepatitis C, Chronic
- Hepatitis, Chronic
- Malignant Neoplasms
- Diabetes Mellitus
- Diabetes Mellitus, Insulin-dependent
- Inflammation
- Dysequilibrium Syndrome
- Encephalitis
- Lupus Erythematosus, Systemic
Interacting Proteins
- ACTN1
- EXOC5
- PRMT6
- TRIM27
Pathways
- Immune Response
- Rna Interference
- Gene Silencing
- Innate Immune Response
- Cell Growth
- Viral Replication
- Cell Proliferation
- Cell Death
- Pathogenesis
- Cell Adhesion
- Inflammatory Response
- Translation
- Cell Cycle
PTMs
- Phosphorylation
- Cleavage
- Acetylation
Research Areas
- DNA Repair
- DNA replication, Transcription, Translation and Splicing
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OAS1
bosterbio.com/bosterbio-gene-info-cards/OAS1
References
PMID: 2416561 by Benech P., et al. Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences.
PMID: 3753689 by Wathelet M.G., et al. Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon.