This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
OPA1 Antibodies
AND OPA1 ELISA kits, OPA1 Proteins
Many biological assays use antibodies to detect OPA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OPA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OPA1 antibodies...
Designing an IHC experiment for OPA1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the OPA1 IHC GuideOPA1 Infographic by Boster Bio
All OPA1 Products
Product
Figures
Specificity
Applications
Price
Anti-OPA1 Antibody Picoband®
7 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB9731
100 μg/vial
Cat # PB9731
100 μg/vial
Anti-OPA1 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00508-1
100 µg/vial
Cat # A00508-1
100 µg/vial
Anti-OPA1 Monoclonal Antibody
2 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00508
100 μl
Cat # M00508
100 μl
OPA1 Overview
Facts about Dynamin-like 120 kDa protein, mitochondrial.
Dynamin-like 120 kDa protein, mitochondrial (OPA1)
Dynamin-related GTPase that's essential for normal mitochondrial morphology by regulating the balance between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is necessary for optimal activity in promoting mitochondrial fusion (PubMed:17709429).
Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is reduced, and is strongly increased by interaction with lipid membranes (PubMed:20185555).
Gene Information
| Human | |
|---|---|
| Gene Name: | OPA1 |
| Uniprot: | O60313 |
| Entrez: | 4976 |
Family
| Belongs to: |
|---|
| TRAFAC class dynamin-like GTPase superfamily |
Alternative Names
BERHS; EC 3.6.5.5; FLJ12460; KIAA0567dynamin-like 120 kDa protein, mitochondrial; LargeG; lilr3; MGM1; mitochondrial dynamin-like GTPase; MTDPS14; NPG; NPGlargeG; NTG; NTGmitochondrial dynamin-like 120 kDa protein; OPA1; optic atrophy 1 (autosomal dominant); Optic atrophy protein 1
Molecular Weight
Mass (kDA):
111.631 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q29 |
| Sequence: | 3; NC_000003.12 (193593144..193697811) |
Tissue Specificity
Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Isoform 1 expressed in retina, skeletal muscle, heart, lung, ovary, colon, thyroid gland, leukocytes and fetal brain. Isoform 2 expressed in colon, liver, kidney, thyroid gland and leukocytes. Low levels of all isoforms expressed in a variety of tissues.
Subcellular Localizations
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space. Mitochondrion membrane. Detected at contact sites between endoplamic reticulum and mitochondrion membranes.
Diseases
- Atrophy
- Optic Atrophy
- Optic Atrophy, Autosomal Dominant
- Disorder Of The Optic Nerve
- Mitochondrial Diseases
- Neurodegenerative Disorders
- Optic Atrophy, Hereditary, Leber
- Optic Atrophies, Hereditary
- Nerve Degeneration
- Glaucoma
- Blind Vision
- Visual Impairment
Interacting Proteins
- BNIP3
- LRRK2
- SIRT3
Pathways
- Mitochondrial Fusion
- Mitochondrial Fission
- Cell Death
- Pathogenesis
- Membrane Fusion
- Transport
- Oxidative Phosphorylation
- Aging
- Localization
- Cell Proliferation
- Proteolysis
- Autophagy
- Electron Transport
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
Research Areas
- Apoptosis
- Mitochondrial Fusion Proteins
- Neurodegeneration
- Neuroscience
- Sensory Systems
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OPA1
bosterbio.com/bosterbio-gene-info-cards/OPA1
References
PMID: 20843780 by Wang W., et al. Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.
PMID: 11810270 by Delettre C., et al. Mutation spectrum and splicing variants in the OPA1 gene.