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- Table of Contents
OSBP Antibodies
AND OSBP ELISA kits, OSBP Proteins
Many biological assays use antibodies to detect OSBP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OSBP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OSBP antibodies...
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OSBP Infographic by Boster Bio
All OSBP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M03062
100 µl
Cat # M03062
100 µl
OSBP Overview
Facts about Oxysterol-binding protein 1.
Oxysterol-binding protein 1 (OSBP)
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: namely exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which can be degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols such as 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193).
Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase that dephosphorylates ERK1/2, whereas 25-hydroxycholesterol induces its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 equilibrium (PubMed:18450749).
Gene Information
| Human | |
|---|---|
| Gene Name: | OSBP |
| Uniprot: | P22059 |
| Entrez: | 5007 |
Family
| Belongs to: |
|---|
| OSBP family |
Alternative Names
OSBP1oxysterol-binding protein 1; oxysterol binding protein
Molecular Weight
Mass (kDA):
89.421 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q12.1 |
| Sequence: | 11; NC_000011.10 (59574398..59615774, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Cytoplasm, cytosol. Cytoplasm, perinuclear region. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network. Predominantly cytosolic.
Diseases
- Malignant Neoplasms
- Neoplasms
- Liver Carcinoma
- Hepatitis
- Hepatitis C
- Neoplasm Metastasis
- Carcinoma
- Nervousness
- Hypertensive Disease
- Cholangiocarcinoma
- Adenoma
- Bile Duct Neoplasms
- Malignant Neoplasm Of Adrenal Cortex
Interacting Proteins
- FKBP6
- VAPA
Pathways
- Transport
- Localization
- Golgi Localization
- Cholesterol Efflux
- Sterol Transport
- Secretion
- Ceramide Transport
- Lipid Transport
- Vesicle Transport
- Sterol Homeostasis
- Cholesterol Transport
- Cholesterol Esterification
- Secretory Pathway
PTMs
- Phosphorylation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OSBP
bosterbio.com/bosterbio-gene-info-cards/OSBP
References
PMID: 1970801 by Levanon D., et al. cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19.
PMID: 11278871 by Moreira E.F., et al. Molecular and biochemical characterization of a novel oxysterol- binding protein (OSBP2) highly expressed in retina.