PDS5A Antibodies

AND PDS5A ELISA kits, PDS5A Proteins

Many biological assays use antibodies to detect PDS5A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDS5A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDS5A antibodies...

We validate the specificity of these antibodies to PDS5A by testing them on tissues known to express PDS5A positively and negatively. Browse below to find the PDS5A antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for PDS5A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the PDS5A Western Blot Guide

PDS5A Infographic by Boster Bio

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Anti-SCC112/PDS5A Antibody Picoband®

Western blot analysis of SCC112/PDS5A using anti-SCC112/PDS5A antibody (A06272-1)

IF analysis of SCC112/PDS5A using anti-SCC112/PDS5A antibody (A06272-1)

Flow Cytometry analysis of A431 cells using anti-SCC112/PDS5A antibody (A06272-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A06272-1
100 μg/vial

PDS5A Overview

Facts about Sister chromatid cohesion protein PDS5 homolog A.

PDS5A 3D structure. Source: alphafold

Sister chromatid cohesion protein PDS5 homolog A (PDS5A)

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis into DNA replication.

Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays a significant role in DNA repair. .

Gene Information

Human
Gene Name:	PDS5A
Uniprot:	Q29RF7
Entrez:	23244

Family

Belongs to:

PDS5 family

Alternative Names

Cell proliferation-inducing gene 54 protein; DKFZp686B19246; FLJ41012; KIAA0648MGC131948; PDS5; PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae); PIG54; SCC-112MGC161503; Sister chromatid cohesion protein 112; sister chromatid cohesion protein PDS5 homolog A

Molecular Weight

Mass (kDA):
150.83 kDA

Genomic Context


Human

Location:	4p14
Sequence:	4; NC_000004.12 (39822863..39977956, complement)

Tissue Specificity

Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney.

Subcellular Localizations

Nucleus. Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase.

Diseases

Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Tumor Progression
Malignant Neoplasm Of Breast
Glioma
Cornelia De Lange Syndrome
Kidney Neoplasm
Aneuploidy
Carcinoma
Leukemia, Myelocytic, Acute
Megacolon

Congenital Heart Defects
Myeloid Leukemia
Mammary Neoplasms
Congenital Absence Of Kidney
Congenital Absence
Glioblastoma Multiforme
Primary Neoplasm

Interacting Proteins

CDCA5
RAD21
SMC3
STAG1
STAG2

Pathways

Cell Cycle
Sister Chromatid Cohesion
Chromosome Segregation
Transport
Cell Proliferation
Mitosis
Dna Repair
Spindle Checkpoint
Cell Death
S Phase

Cell Growth
Pathogenesis
Viral Replication
Meiosis
Rna Interference

PTMs

Acetylation

Research Areas

Cell Cycle and Replication
DNA Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDS5A

References

PMID: 15019998 by Kumar D., et al. SCC-112, a novel cell cycle-regulated molecule, exhibits reduced expression in human renal carcinomas.

PMID: 11076961 by Sumara I., et al. Characterization of vertebrate cohesin complexes and their regulation in prophase.