Polycystin-2 Antibodies

Polycystin-2 (PKD2)

Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that's activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Functions as a cation channel involved in fluid-flow mechanosensation from the primary cilium in renal epithelium (PubMed:18695040).

Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores in the endoplasmic reticulum (PubMed:11854751, PubMed:20881056).

Gene Information

Human
Gene Name:	PKD2
Uniprot:	Q13563
Entrez:	5311

Family

Belongs to:
polycystin family

Alternative Names

APKD2; Autosomal dominant polycystic kidney disease type II protein; MGC138466; MGC138468; PC2; Pc-2; PKD4; polycystic kidney disease 2 (autosomal dominant); Polycystic kidney disease 2 protein; polycystin-2; polycystwin; R48321; transient receptor potential cation channel, subfamily P, member 2; TRPP2

Molecular Weight

Mass (kDA):
109.691 kDA

Genomic Context

Human
Location:	4q22.1
Sequence:	4; NC_000004.12 (88007635..88077779)

Tissue Specificity

Detected in fetal and adult kidney (PubMed:10770959). Detected at the thick ascending limb of the loop of Henle, at distal tubules, including the distal convoluted tubule and cortical collecting tubules, with weak staining of the collecting duct (PubMed:10770959). Detected on placenta syncytiotrophoblasts (at protein level) (PubMed:26269590). Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes.

Subcellular Localizations

Cell projection, cilium membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cytoplasmic vesicle membrane. Golgi apparatus. PKD2 localization to the plasma and ciliary membranes requires PKD1. PKD1:PKD2 interaction is required to reach the Golgi apparatus form endoplasmic reticulum and then traffic to the cilia (By similarity). Retained in the endoplasmic reticulum by interaction with PACS1 and PACS2 (PubMed:15692563). Detected on kidney tubule basolateral membranes and basal c

Diseases

• Polycystic Kidney Diseases
• Kidney Diseases
• Polycystic Kidney, Autosomal Dominant
• Kidney Failure, Chronic
• Cystic Kidney Diseases
• Kidney Failure
• Hereditary Diseases
• Autosomal Recessive Polycystic Kidney Disease
• Hypertensive Disease
• Neoplasms
• Liver Diseases
• Cystic Disease -retired-
• Aneurysm

• Tissue Adhesions
• Fibrosis
• Malignant Neoplasms
• Polycystic Liver Disease
• Intracranial Aneurysm
• Simple Renal Cyst
• Inflammation

Interacting Proteins

• Hax1
• ID2
• KRT40
• KRTAP10-8
• MAGEA8

• PKD1
• Pkd1
• PLSCR1
• TRPC1
• Trpv4

Pathways

• Pathogenesis
• Localization
• Cell Proliferation
• Transport
• Secretion
• Translation
• Cell Growth
• Cell Cycle
• Angiogenesis
• Mating
• Kidney Development
• Cell Adhesion
• Nuclear Export

• Cell Division
• Fertilization
• Glomerular Filtration
• Rna Interference
• Epithelial Cell Proliferation
• Cell Death
• Sperm Storage

PTMs

• Phosphorylation
• Cleavage
• Ubiquitination
• Glycosylation
• Dephosphorylation

• Biotinylation
• Acetylation
• Reduction
• Deacetylation
• Ribosylation

Research Areas

• Cancer
• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PKD2

Boster Bio Optimization Guide - Best Uses Of The PKD2 Marker

In this Boster Bio optimization guide, you'll discover tips to optimize your experiments, troubleshoot common problems, and identify the best practices. With the right guidance, you can improve the quality of your results. Unfortunately, every experiment runs into trouble at some point. Troubleshooting guides can help you eliminate many of the causes of error. By following their advice, you'll be well on your way to achieving the best possible results with your Boster Bio.

Boster Bio optimisation

Many questions arise while optimizing an experiment in the Boster Bio system. The use of optimization guides can provide valuable information that informs decisions, improves the results, and prevents problems. Every researcher experiences some kind of trouble with their experiments at some point. However, proper controls can eliminate many sources of error. Troubleshooting guides can help researchers identify these issues and correct them before they become a problem.

Boster Bio troubleshooting

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