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- Table of Contents
PRKAA1 Antibodies
AND PRKAA1 ELISA kits, PRKAA1 Proteins
Many biological assays use antibodies to detect PRKAA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRKAA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRKAA1 antibodies...
Designing a Western blot for PRKAA1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PRKAA1 Western Blot GuidePRKAA1 Infographic by Boster Bio
All PRKAA1 Products
Product
Figures
Specificity
Applications
Price
Anti-AMPK alpha 1 PRKAA1 Rabbit Monoclonal Antibody
12 Citations
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00994
100 μl
Cat # M00994
100 μl
Anti-AMPK alpha 1/PRKAA1 Antibody Picoband®
13 Citations
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00994-6
100 μg/vial
Cat # A00994-6
100 μg/vial
Anti-AMPK alpha 1/PRKAA1 Antibody Picoband®
4 Citations
Human, Mouse, Rat
ELISA, WB
$370
Cat # A00994-3
100 μg/vial
Cat # A00994-3
100 μg/vial
Human
IP, IF, ICC, WB
$370
Cat # P00994-1
100 μl
Cat # P00994-1
100 μl
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00995
100 μl/vial
Cat # M00995
100 μl/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00994-2
20μL, 40μL, 100μL, 200μL
Cat # M00994-2
20μL, 40μL, 100μL, 200μL
Human
$960
Cat # LS005562
20 µg, 100 µg
Cat # LS005562
20 µg, 100 µg
Human, Mouse, Rat
ELISA
$540
Cat # EKC2349
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2349
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1936
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1936
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1027
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1027
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
IHC, WB
$370
Cat # M00994-3
100 μl/vial
Cat # M00994-3
100 μl/vial
PRKAA1 Overview
Facts about 5'-AMP-activated protein kinase catalytic subunit alpha-1.
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays an integral role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation.
AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin.
Gene Information
| Human | |
|---|---|
| Gene Name: | PRKAA1 |
| Uniprot: | Q13131 |
| Entrez: | 5562 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK alpha 1; AMPK alpha 1,5'-AMP-activated protein kinase, catalytic alpha-1 chain; AMPK subunit alpha-1; AMPK; AMPK1; AMPKa1; EC 2.7.11; EC 2.7.11.1; MGC33776; MGC57364; PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit
Molecular Weight
Mass (kDA):
64.009 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5p13.1 |
| Sequence: | 5; NC_000005.10 (40759379..40798195, complement) |
Subcellular Localizations
Cytoplasm. Nucleus. In response to stress, recruited by p53/TP53 to specific promoters.
Diseases
- Malignant Neoplasms
- Neoplasms
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Insulin Sensitivity
- Obesity
- Inflammation
- Hypoxia
- Insulin Resistance
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Hypertrophy
Interacting Proteins
- ABI2
- AES
- BHLHE40
- CDX4
- FSBP
- GOLGA2
- HMBOX1
- HSP90AB1
- IKZF3
- INO80E
Pathways
- Energy Homeostasis
- Cell Death
- Secretion
- Transport
- Cell Proliferation
- Fatty Acid Oxidation
- Cell Differentiation
- Glycolysis
- Oxidative Phosphorylation
- Localization
- Autophagy
- Gene Silencing
- Stem Cell Differentiation
PTMs
- Phosphorylation
- Oxidation
- Acetylation
Research Areas
- Apoptosis
- Autophagy
- Cancer
- Hypoxia
- MAP Kinase Signaling
- mTOR Pathway
- Signal Transduction
- Translation Control
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKAA1
bosterbio.com/bosterbio-gene-info-cards/PRKAA1
References
PMID: 8557660 by Stapleton D., et al. Mammalian AMP-activated protein kinase subfamily.
PMID: 9857077 by Crute B.E., et al. Functional domains of the alpha1 catalytic subunit of the AMP- activated protein kinase.
3 Publications of Boster PRKAA1 Antibodies & ELISA Kits
- PubMed ID: 10.1002/jcb.26275, Effect of metformin on ossification and inflammation of fibroblasts in ankylosin...
- PubMed ID: 29033843, The apolipoprotein A?I mimetic peptide, D?4F, restrains neointimal formation thr...
- PubMed ID: 25162824, Hou S, Zheng F, Li Y, Gao L, Zhang J. Int J Mol Sci. 2014 Aug 26;15(9):15026-43....
*More publications can be found for each product on its corresponding product page