PRKCI Antibodies

Protein kinase C iota type (PRKCI)

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis.

In cultured neurons, prevents amyloid beta protein-induced apoptosis by disrupting cell death process at a really early step. Can form a protein complex in non- small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed invasion and growth.

Gene Information

Human
Gene Name:	PRKCI
Uniprot:	P41743
Entrez:	5584

Family

Belongs to:
protein kinase superfamily

Alternative Names

aPKC-lambda/iota; Atypical protein kinase C-lambda/iota; DXS1179E; EC 2.7.11; EC 2.7.11.13; MGC26534; nPKC-iota; PKCI; PRKC-lambda/iota; protein kinase C iota type; protein kinase C, iota

Molecular Weight

Mass (kDA):
68.262 kDA

Genomic Context

Human
Location:	3q26.2
Sequence:	3; NC_000003.12 (170222424..170305981)

Tissue Specificity

Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers.

Subcellular Localizations

Cytoplasm. Membrane. Endosome. Nucleus. Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Malignant Neoplasm Of Lung
• Malignant Neoplasm Of Prostate
• Cell Transformation, Neoplastic
• Lung Neoplasms
• Non-small Cell Lung Carcinoma
• Prostatic Neoplasms
• Hyperplasia
• Neoplasm Metastasis
• Diseases, Protein Folding

• Metastatic Malignant Neoplasm To The Lymph Node
• Mood Disorders
• Ovarian Serous Adenocarcinoma
• Malignant Neoplasm Of Breast
• Nervousness
• Invasive Lobular Breast Carcinoma

Interacting Proteins

• CDC42
• ELF3
• MARK4
• PARD3
• PARD6A

• PARD6B
• PARD6G
• PNMA1
• PRKCZ
• RAC1

• SOX2
• SQSTM1
• YWHAH

Pathways

• Organ Morphogenesis
• Ribosome Biogenesis
• Reverse Transcription
• Golgi Localization
• Dna Amplification
• Cell Cycle
• Protein Folding
• Heart Morphogenesis

• Aging
• Wound Healing
• Localization

PTMs

• Phosphorylation

Research Areas

• Protein Kinase
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKCI

Boster Bio: Best Uses Of The PRKCI Marker

David Scott and Josh Weinstein have developed a pipeline for analyzing protein-protein interactions and their association with cellular signaling pathways. Their article, published in Nature Biotech 2013, discusses their work. Read this article to learn more. It also covers the process for analyzing data obtained with this pipeline. In this article, we will look at how to use this pipeline to determine whether a protein is potentially mutated.

Data Analysis Pipeline Developed By David Scott and Josh Weinstein

The Data Analysis Pipeline Developed By David Scott And Josh Weinstein helps researchers analyze large datasets for new research purposes. Its methods should be publicly available so that researchers can easily compare them to new research projects. The project began as an informal collaboration among TCGA Research Network members, but quickly grew to include a wide variety of other interested researchers. As the project expanded, formal pipelines were developed to create a coherent working base for data.

Published in Nature Biotech 2013

A report published in the journal Nature Biotechnology in 2013 highlights the current state of the European biotech start-up landscape. Authors of the report include Forbion, one of the leading life sciences venture capital firms. The report includes an analysis of the current biotech start-up landscape across eight titles in Europe. Read the report to learn more about the importance of investing in European biotech start-ups. This paper provides an overview of the current biotech start-up landscape, including the key characteristics of European and global start-up companies.

Discussed by David Scott and Josh Weinstein

The Simpsons' executive producer and head writer, Josh Weinstein, is a former member of the television show's writing staff. Before his work on The Simpsons, Weinstein was an editor at Stanford Chaparral and a co-host of the variety show Sunday Best. In addition to writing for The Simpsons, Weinstein has also produced several films, including the critically acclaimed comedy 'The Grand Tour.'

The two men share several traits. For example, each has an obsession with keeping things clean and orderly. Josh likes to chant out a phrase in his head to drown out distracting noises. Meanwhile, Bill says the phrase in various situations, including when he checks his homework. They say it to different tunes. They are surprisingly similar. In the end, Josh is a more "realist" person than Bill, but they still disagree about some things.