Ptpn5 Antibodies

Tyrosine-protein phosphatase non-receptor type 5 (Ptpn5)

May regulate the action of several effector molecules involved in synaptic plasticity and neuronal cell survival, such as MAPKs, Src family kinases and NMDA receptors. .

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Gene Information

Mouse
Gene Name:	Ptpn5
Uniprot:	P54830
Entrez:	19259

Family

Belongs to:
protein-tyrosine phosphatase family

Alternative Names

EC 3.1.3.48; FLJ14427; Neural-specific protein-tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched); protein-tyrosine phosphatase striatum-enriched; STEPPTPSTEP; Striatum-enriched protein-tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 5

Molecular Weight

Mass (kDA):
60.815 kDA

Genomic Context

Mouse
Location:	7 B3|7 30.7 cM
Sequence:	7;

Tissue Specificity

STEP20 is expressed only in the CNS.

Diseases

• Nervousness
• Alzheimer's Disease
• Posttransfusion Purpura
• Depressive Disorder
• Epilepsy
• Fragile X Syndrome
• Ischemia
• Amnesia
• Huntington Disease
• Pain
• Neurofibrillary Tangles
• Stress, Psychological
• Mental Disorders

• Brain Diseases
• Neuropathology Disease
• Neurodegenerative Disorders
• Cerebrovascular Accident
• Status Epilepticus
• Plaque, Amyloid
• Stereotyped Behavior

Pathways

• Endocytosis
• Localization
• Proteolysis
• Synaptic Transmission
• Translation
• Receptor Internalization
• Cell Death
• Cell Adhesion
• Protein Phosphorylation
• Regulation Of Cell Adhesion
• Regeneration

• Neuroprotection
• Sensitization
• Cellular Localization
• Cognition
• Exocytosis
• Rna Interference

PTMs

• Phosphorylation
• Dephosphorylation

• Cleavage
• Ubiquitination

• Biotinylation

Research Areas

• Alzheimers Research
• Cancer
• Cellular Markers
• Hypoxia
• Neurodegeneration

• Neuroscience
• Protein Phosphatase
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ptpn5

Best Uses Of The PTPN5 Marker

This article will tell you more about Steven Boster. You will learn about the PTPN5 Marker, historie and applications. Boster's biography explains more about the PTPN5 markers. This article will also give you helpful tips on how to properly use the PTPN5 marking device. The PTPN5 marking is a great choice for many purposes.

Steven Boster

After a long fight with COVID-19 Steve Boster, a beloved father-grandfather, died in June 2022. Steve was born in Joliet, IL and was a long-standing retail sales manager. He was also a Concordia Hall member in Staunton, VA. Steve is survived in death by his wife Nina, their six children and their parents, two daughters and two of his brothers. His son Jonathan Boster, Crystal, and granddaughter Cory live in Herrin, IL.

Steve enjoyed southern gospel music and often sang so low that it was nearly audible. He also loved sports, especially opposing teams. He loved auto racing and was a regular at the local track on Friday nights. He also attended dirt track racing and other events on weekends. Steve loved fishing and hunting with his family. He grew to love the PTPN5 marker in his spare time.

Historie

PTPN5 encoding a tyrosine phosphatase is a protooncogene. It has been thought to be a potential tumor suppressor. However recent studies suggest that PTP1B promotes the development of tumorigenesis. It activates and dephosphorylates breast cancer cell-line c2-Src. PTP1B interacts with the FERM domain, a scaffold protein.

The Hubrecht Institute has a long tradition of signal transduction research. Den Hertog and his colleagues have been studying the role of PTPs within stem cell biology and developmental biology. The presentation will cover the latest discoveries in understanding PTP function. It will also be addressed how PTPs play a role in development and disease. In addition, we will discuss how the PTP5 gene may be manipulated to influence human health.

Two mutations can be found in the PTP5 marker that encodes PTPN5. The C1858T mutant encodes a PTPN5 variation containing a LYP protein with a prolinerich region. This mutation prevents the formation a LYP/CSK complex. The R620W variant inhibits Tcell signaling more efficiently than the wildtype enzyme in Jurkat Tcells and human Tcells. This contradicts previous theories that LYP/CSK work together to downregulate TCR-signaling.

The Historie for the PTPN5 genes is largely unknown. However, it has been linked to several human diseases. PTPs are a promising target to develop new drugs and treatments. Their role in the immune system is not redundant. In addition, PTPs are relatively easy to identify in blood and urine samples. So far, this gene is an attractive drug target.

PTPN5 Marker

The PTPN5 mark is a gene which regulates synaptic force. It has been shown that in rats undergoing stressful experiences, PTPN5 expression is reduced. Furthermore, PTPN5 expression is associated with susceptibility to morphological and cognitive changes. This gene may be useful in the prevention of stress-related disorders or diseases. This research provides the first evidence to support the role of PTPN5 in these conditions.

PTPN5 is also involved in regulation of targets other that ERK1/2. It regulates Fyn-phosphorylation as well as glutamate receptor transport. ERK1/2 activity is also implicated in the onset and maintenance of psychiatric disorders. It is therefore crucial to determine the role of this protein for these disorders.

Lentivirus expressing PTPN5 (or other shRNAs) was injected bilaterally to DH. Lentivirus stocks were injected with a blunt tip needle into the DH using a Hamilton syringe. After that, primary cultures were incubated in vitro in hippocampal neural neurons for five days. The cell extracts were collected after fifteen day.

Knockdown of PTPN5 prolongs ERK1/2 activity. It also delays the repair of KV4.2 channels and increases stress-related phenotypes. Conversely, overexpression of PTPN5 promotes physiological recovery and reduces susceptibility to stress-related cognitive changes. This research is important in human health and should be pursued further.

Applications

The PTPN5 genes are a member in the protein tyrosine phosphatase, (PTP), family. They have been implicated both in memory and learning. A recent study looked at the association of this gene and schizophrenia. The study involved 868 schizophrenia patients and 286 controls. If the tumor contained its mRNA, the PTPN5 gene was found to be associated with schizophrenia.

PSA and acid-phosphatase tests are used for diagnosing prostate cancer. PSA is a marker that is specific for the prostate and can be elevated in patients with inflammation, benign prostate hyperplasia, and other inflammatory conditions. Additional clarification is required for PSA levels above 4ng/mL. The use of marker sequencing technology has allowed for more accurate results. This marker can be used to diagnose prostate carcinoma.