ROR2 Antibodies

Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2)

Tyrosine-protein kinase receptor which might be involved in the early formation of the chondrocytes. It seems to be needed for cartilage and growth plate development (By similarity).

Phosphorylates YWHAB, resulting in induction of osteogenesis and bone formation (PubMed:17717073). By comparison, has also been demonstrated to possess very little tyrosine kinase activity in vitro.

Gene Information

Human
Gene Name:	ROR2
Uniprot:	Q01974
Entrez:	4920

Family

Belongs to:
protein kinase superfamily

Alternative Names

BDB; BDB1; EC 2.7.10.1; MGC163394; neurotrophic tyrosine kinase receptor-related 2; Neurotrophic tyrosine kinase, receptor-related 2; NTRKR2; NTRKR2tyrosine-protein kinase transmembrane receptor ROR2; receptor tyrosine kinase-like orphan receptor 2; ROR2

Molecular Weight

Mass (kDA):
104.757 kDA

Genomic Context

Human
Location:	9q22.31
Sequence:	9; NC_000009.12 (91722598..91950228, complement)

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

• Brachydactyly
• Malignant Neoplasms
• Robinow Syndrome
• Neoplasms
• Limb Deformities, Congenital
• Cell Invasion
• Dwarfism
• Malignant Neoplasm Of Stomach
• Neoplasm Metastasis
• Carcinoma
• Dysplasia
• Nervousness
• Plant Diseases

• Tissue Adhesions
• Syndactyly
• Osteosarcoma
• Craniofacial Abnormalities
• Stomach Neoplasms
• Cell Transformation, Neoplastic
• Congenital Hand Deformities

Interacting Proteins

• HSP90AB1
• PRR20D

Pathways

• Cell Migration
• Localization
• Convergent Extension
• Osteoblast Differentiation
• Cell Proliferation
• Pathogenesis
• Gastrulation
• Secretion
• Cell Adhesion
• Cell Motility
• Cell Fate Determination
• Cell Death
• Chondrocyte Differentiation

• Cell Differentiation
• Tissue Morphogenesis
• Bone Resorption
• Ossification
• Cell-cell Adhesion
• Glycosylation
• Somitogenesis

PTMs

• Phosphorylation
• Glycosylation

• Cleavage
• Methylation

• Ribosylation

Research Areas

• Protein Kinase
• Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ROR2

Boster Bio - Best Uses Of The ROR2 Marker

Boster Bio: Steven Boster - The Biography and Primary Antibodies

His research

His research on ROR2 has revealed many interesting properties of the protein. It appears to be a tumor-suppressor and can also encourage tumor growth. Overexpression of the protein correlates with poorer prognoses and increased recurrence rates. And it can also help predict the outcome of a patient with a specific type of cancer. This is one example of the many ways a doctor can use this information.

His team discovered that ROR2 promotes EMT, by upregulating transcription factor levels and inducing a cadherin switch. Furthermore, ROR2 promotes melanoma cell invasion and necrosis in xenotransplanted mice. While his research on the ROR2 marker is still in its early stages, this finding is promising. ROR2 could be a promising new way to treat patients suffering from this deadly disease.

His research on ROR2 markers has produced many interesting results. ROR2 can be overexpressed to increase the expressions of vimentin and N cadherin, while ROR2 can reduce the expression E-cadherin. This suggests that ROR2 inhibits proliferation and suppresses tumor growth in vivo. These findings are important for the future of melanoma treatment and the development of novel therapies.

RoR2 is important for NMDAR synaptic transmission basal NMDAR in addition to its tumor suppression effects. It regulates the responses of basal synapses, which is important for the development of many types of cancers. This discovery also points out the dual function of ROR receptors for melanoma. This research also reveals the role of ROR2 in the epithelial-mesenchymal transition phenotype.

His primary antibodies

To determine if His primary antibody recognizes the ROR2 receptor-corresponding protein, we first used NOF cells to express the anti-ROR2 flog plasmid. The cells were serum-starved overnight and diluted 1x106 cells/ml. Then, the cells were transfected with 2500ng of p.FLAG plasmid by using Lipofectamine 3000.

ROR2 is a tyrosine kinase receptor that promotes proliferation, survival, migration, and metastasis. Researchers have found that ROR2 levels are higher in aggressive stages of melanoma. The study used loss-of function and gain-of function experiments to determine the biological functions of ROR2 during melanoma. The study also examined the effects of chemotherapeutic drug on cell cycle and expression of cell-death protein in ROR2-positive cells.

His primary antibodies using ROR2 markers detect the endogenous ROR2 level. These antibodies were purified by affinity chromatography using immunogens to block ROR2 signalling. Several recent studies have indicated that the Wnt5a-ROR2-Jun pathway may be involved in fibrosis pathogenesis. ROR2-Jun can be a therapeutic target in ovarian carcinoma.

In 2003, the ROR2 marker was identified in E13.5 embryos. ROR2 is expressed in the developing ribs and vertebral anlagen as well as the heart and lung. It colocalizes also with a subset a-SMA positive cells. This marker could also serve as an important marker for other embryonic paths.

ROR2 is also expressed in the spinal cords and brains of mice suffering from chronic constriction injury. In this disease model ROR2 promoter of demethylation significantly affected the expression of spinal neuronal cells. CCI-induced spine sensitization was reversed and CCI-induced pain behaviour was disrupted by the knockdown of ROR2. These studies prove that ROR2 can play an important role in neuropathic and neuropathic pain.

It is crucial to note that the ROR2 receptacle is essential for neural development. ROR2 activation promotes Disheveled2 and axonal branches in hippocampal neural cells. Knockdown of ROR2 reduces NMDA-mediated synaptic transmission. If you are searching for an antibody to target ROR2 in human neurons, look no further.

Trustworthiness

Research that uses a specific gene or molecule may have an impact on the accuracy of the results. In addition to affecting the result of a test, a gene's reliability may also affect the credibility of an entire study. In this case, the ROR2 gene may be a reliable choice for the study. Many qualitative researchers believe that reliability is sufficient. However, they may disagree on the issue about credibility. Fortunately, researchers have begun to recognize that credibility and dependability are not the same thing.