60S ribosomal protein L13a (Rpl13a)

Connected with ribosomes but isn't required for canonical ribosome function and contains extra-ribosomal functions (By similarity). Part of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma- triggered transcript-selective translation inhibition in inflammation processes.

Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles to the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. From the GAIT complex interacts with m7G cap-bound eIF4G at or close to the eIF3-binding website and blocks the recruitment of the 43S ribosomal complex.