RXRA Antibodies

Retinoic acid receptor RXR-alpha (RXRA)

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers for their target response elements in reaction to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.

The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid.

Gene Information

Human
Gene Name:	RXRA
Uniprot:	P19793
Entrez:	6256

Family

Belongs to:
nuclear hormone receptor family

Alternative Names

FLJ00280; FLJ00318; FLJ16020; MGC102720; NR2B1; NR2B1FLJ16733; Nuclear receptor subfamily 2 group B member 1; retinoic acid receptor RXR-alpha; Retinoid X receptor alpha; retinoid X receptor, alpha; RXR alpha; RXRA

Molecular Weight

Mass (kDA):
50.811 kDA

Genomic Context

Human
Location:	9q34.2
Sequence:	9; NC_000009.12 (134326455..134440586)

Tissue Specificity

Highly expressed in liver, also found in lung, kidney and heart.

Subcellular Localizations

Nucleus. Cytoplasm. Mitochondrion. Localization to the nucleus is enhanced by vitamin D3 (PubMed:15509776). Nuclear localization may be enhanced by the interaction with heterodimerization partner VDR (PubMed:12145331). Translocation to the mitochondrion upon interaction with NR4A1 (PubMed:17761950, PubMed:15509776). Increased nuclear localization upon pulsatile shear stress (PubMed:28167758).

Diseases

• Malignant Neoplasms
• Neoplasms
• Refractory Anemia With Ringed Sideroblasts
• Carcinoma
• Inflammation
• Endometrial Polyp
• Leukemia
• Acute Promyelocytic Leukemia
• Prostatic Neoplasms
• Inflammatory Response
• Insulin Resistance
• Colorectal Cancer
• Malignant Neoplasm Of Prostate

• Lipodystrophy
• Dyslipidemias
• Myeloid Leukemia, Chronic
• Myeloid Leukemia
• Renal Cell Carcinoma
• Neurofibromatosis 1
• Heart Diseases

Interacting Proteins

• BHLHE40
• MED1
• MED25
• NCOA1
• NCOA2

• Ncoa6
• NR1H3
• PIK3R1
• RARA
• STAT1

• VDR

Pathways

• Cell Differentiation
• Localization
• Immune Response
• Heart Development
• Inflammatory Response
• Cell Proliferation
• Parturition
• Methylation
• Pathogenesis
• Secretion
• Cell Activation
• Developmental Process
• Brain Development

• Cytokine Secretion
• Glucose Homeostasis
• Cell Division
• Translation
• Innate Immune Response
• Eye Development
• Embryonic Morphogenesis

PTMs

• Methylation

• Sumoylation

• Carboxylation

Research Areas

• Cancer
• Chromatin Research
• Lipid and Metabolism
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RXRA

Boster Bio Anti-RXRA Marker

You've come to the right place in the event you're looking for Anti RXRA Antibody. Boster Bio's product (catalog no A01299) is a binding agent for the RXRA Marker. It can also bind to human, mouse, and rat samples. In this article, we'll go over how this antibody works, what targets it can recognize, and what clinical applications it has to provide.

Anti-RXRA Marker

Bostern Bio's Anti RXRA Marker is an extremely sensitive and specific antibody that reacts with human Retinoid X Receptor Alpha. It has been tested and validated for use in Western Blotting, Immunohistochemistry, and ELISA. The rabbits were immunized with a synthetic protein that contains 21 to 52 amino acids.

SiRNA duplexes

Biological assays are usually done using antibodies to retinoid X receptor alpha (RXRA). These antibodies are polyclonal or monoclonal and react with RXRA in different animal specimens. Boster Bio makes antibodies against RXRA using mice and rabbits as models. Retinoid X Receptors are homodimers that bind to target response elements. Retinoid-X Receptors regulate gene expression by binding to highly active ligands.

The RXRA marker was created to identify the most expressed protein-coding genes. It is particularly useful in identifying liver-related pathways that are not functioning properly. This marker is suitable for human and animal tissues as well as research into infectious diseases. It is also employed in cancer research. For more information, please visit Boster Bio's website. These experts are ready to answer all your questions.

Targets

The target region of the marker is home to a variety of hormone response elements (HREs). The target regions of the genes are identified with a position weight matrix which can be derived from Balmer and Blomhoff or DREME. ROC curves reveal the enrichment of HREs within target regions. The red and green curves highlight the compound motif (DR0-1-2-5) and the blue and purple curves show non-canonical half-site sequences.

The AGN194204 inhibitor inhibited the growth of human breast cancer cell lines. The ligands stopped the growth of all-trans RA-resistant breast cancer cells. These substances were safe in animal models and caused regression in phase II studies. RXR-a's overexpression has been shown to increase the expression of ductal carcinoma genes in situ.

Recent research has revealed that a PPAR ligand AGN194204 along with the selective RXR–g ligand LA had similar effects on human breast cancer cells. Both ligands triggered antiproliferative as also apoptotic gene expression in breast cancer cell lines. The RXR-selective ligand AGN194204 increased the antiproliferative , as well as Apoptotic effects of PPAR-mediated gene expression in MCF7 breast cancer cells and T47D cells.

The RXR protein coimmunoprecipitated several other nuclear receptors, including both PPARb and. The coimmunoprecipitation experiments further proved the heterodimerization of the RXR with other nuclear receptors. The RXR coimmunoprecipitation results also indicated that the RXR ligands induced robust gene induction.

Clinical applications

The RXRA gene is an integral component of many physiologic pathways, including cholesterol metabolism metabolic pathways, bile acid metabolism the metabolism of steroid and the metabolism of xenobiotics. The RXRA marker is widely used in clinical settings. Although the gene was identified in 1998, its physiology remains a mystery. The goal of further studies is to identify its function. However the gene's expression recently gained momentum because of recent publications.

Recent studies have revealed that RXRA and RAR form a heterodimer which is capable of attracting coactivators. RXR and the apo-retinoic acids receptor form a heterodimer each time they interact. Coactivators block coactivators from binding to the receptor. This makes it difficult for us to recognize disease progression in the same cell.

Rexinoids on the contrary, are more stable and have an improved safety profile. They collaborate with ATRA by encouraging CCR9 expression, and then migration to CCL25 membrane. This is in line with the innate immune system's desire to recognize and respond to a ligand, and rexinoids can enhance this process. These compounds, even though they are toxic and unstable are beneficial for T cell migration and mucosal Homing.