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- Table of Contents
RXRA Antibodies
AND RXRA ELISA kits, RXRA Proteins
Many biological assays use antibodies to detect RXRA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RXRA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RXRA antibodies...
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RXRA Infographic by Boster Bio
All RXRA Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01299-1
100 μg/vial
Cat # A01299-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M01299
100 μg/vial
Cat # M01299
100 μg/vial
Human, Mouse, Rat
IP, IF, ICC, WB
$370
Cat # M01299-2
100 μl/vial
Cat # M01299-2
100 μl/vial
Human
$628
Cat # LS006256
20 µg, 100 µg
Cat # LS006256
20 µg, 100 µg
RXRA Overview
Facts about Retinoic acid receptor RXR-alpha.
Retinoic acid receptor RXR-alpha (RXRA)
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers for their target response elements in reaction to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.
The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid.
Gene Information
| Human | |
|---|---|
| Gene Name: | RXRA |
| Uniprot: | P19793 |
| Entrez: | 6256 |
Family
| Belongs to: |
|---|
| nuclear hormone receptor family |
Alternative Names
FLJ00280; FLJ00318; FLJ16020; MGC102720; NR2B1; NR2B1FLJ16733; Nuclear receptor subfamily 2 group B member 1; retinoic acid receptor RXR-alpha; Retinoid X receptor alpha; retinoid X receptor, alpha; RXR alpha; RXRA
Molecular Weight
Mass (kDA):
50.811 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.2 |
| Sequence: | 9; NC_000009.12 (134326455..134440586) |
Tissue Specificity
Highly expressed in liver, also found in lung, kidney and heart.
Subcellular Localizations
Nucleus. Cytoplasm. Mitochondrion. Localization to the nucleus is enhanced by vitamin D3 (PubMed:15509776). Nuclear localization may be enhanced by the interaction with heterodimerization partner VDR (PubMed:12145331). Translocation to the mitochondrion upon interaction with NR4A1 (PubMed:17761950, PubMed:15509776). Increased nuclear localization upon pulsatile shear stress (PubMed:28167758).
Diseases
- Malignant Neoplasms
- Neoplasms
- Refractory Anemia With Ringed Sideroblasts
- Carcinoma
- Inflammation
- Endometrial Polyp
- Leukemia
- Acute Promyelocytic Leukemia
- Prostatic Neoplasms
- Inflammatory Response
- Insulin Resistance
- Colorectal Cancer
- Malignant Neoplasm Of Prostate
Interacting Proteins
- BHLHE40
- MED1
- MED25
- NCOA1
- NCOA2
- Ncoa6
- NR1H3
- PIK3R1
- RARA
- STAT1
Pathways
- Cell Differentiation
- Localization
- Immune Response
- Heart Development
- Inflammatory Response
- Cell Proliferation
- Parturition
- Methylation
- Pathogenesis
- Secretion
- Cell Activation
- Developmental Process
- Brain Development
PTMs
- Methylation
Research Areas
- Cancer
- Chromatin Research
- Lipid and Metabolism
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RXRA
bosterbio.com/bosterbio-gene-info-cards/RXRA
References
PMID: 2159111 by Mangelsdorf D.J., et al. Nuclear receptor that identifies a novel retinoic acid response pathway.
PMID: 18619963 by Kobayashi T., et al. DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system.
1 Publications of Boster RXRA Antibodies & ELISA Kits
- PubMed ID: 10.1539/joh.L8084, Effects of Chronic Noise Exposure on Spatial Learning and Memory of Rats in Rela...
*More publications can be found for each product on its corresponding product page