TNRC6A Antibodies

AND TNRC6A ELISA kits, TNRC6A Proteins

Many biological assays use antibodies to detect TNRC6A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNRC6A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNRC6A antibodies...

We validate the specificity of these antibodies to TNRC6A by testing them on tissues known to express TNRC6A positively and negatively. Browse below to find the TNRC6A antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TNRC6A Infographic by Boster Bio

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Anti-TNRC6A Antibody

Western blot analysis of extracts of various cell lines, using TNRC6A antibody at 1:1000 dilution

Immunofluorescence analysis of U2OS cells using TNRC6A antibody at dilution of 1:100

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A04293
100ul

TNRC6A Overview

Facts about Trinucleotide repeat-containing gene 6A protein.

TNRC6A 3D structure. Source: alphafold

Trinucleotide repeat-containing gene 6A protein (TNRC6A)

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins.

As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. .

Gene Information

Human
Gene Name:	TNRC6A
Uniprot:	Q8NDV7
Entrez:	27327

Family

Belongs to:

GW182 family

Alternative Names

CAG repeat protein 26; CAGH26FLJ22043; DKFZp666E117; EMSY interactor protein; Glycine-tryptophan protein of 182 kDa; GW182 autoantigen; GW182GW1; KIAA1460EDIE; MGC75384; Protein GW1; TNRC6; trinucleotide repeat containing 6; trinucleotide repeat containing 6A; trinucleotide repeat-containing gene 6A protein

Molecular Weight

Mass (kDA):
210.297 kDA

Genomic Context


Human

Location:	16p12.1
Sequence:	16; NC_000016.10 (24610205..24826223)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Cytoplasm, P-body. Mammalian P-bodies are also known as GW bodies (GWBs).

Diseases

Malignant Neoplasms
Neoplasms
Stomach Neoplasms
Neoplasm Metastasis
Mutation, Out-of-frame
Intraepithelial Neoplasia
Malignant Neoplasm Of Breast
Neurodegenerative Disorders
Trinucleotide Repeat Expansion
Carcinoma
Sjogren's Syndrome
Lupus Erythematosus, Systemic
Colorectal Cancer

Rheumatoid Arthritis
Esophageal Neoplasms
Low-frequency Microsatellite Instability
Biliary Cirrhosis
Malignant Neoplasm Of Prostate
Cell Transformation, Neoplastic
Malignant Squamous Cell Neoplasm

Interacting Proteins

AGO1
AGO2
AGO3
AGO4
CNOT1

PABPC1
PAN3
TRIP13

Pathways

Gene Silencing
Translation
Rna Interference
Pathogenesis
Localization
Nuclear Export

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNRC6A

References

PMID: 11950943 by Eystathioy T., et al. A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles.

PMID: 9225980 by Margolis R.L., et al. cDNAs with long CAG trinucleotide repeats from human brain.