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- Table of Contents
Facts about Terminal uridylyltransferase 4.
Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 distinct uridylation mechanics (PubMed:25979828).
Human | |
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Gene Name: | TUT4 |
Uniprot: | Q5TAX3 |
Entrez: | 23318 |
Belongs to: |
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DNA polymerase type-B-like family |
Terminal uridylyltransferase 4
Mass (kDA):
185.166 kDA
Human | |
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Location: | 1p32.3 |
Sequence: | 1; NC_000001.11 (52423275..52553463, complement) |
Nucleus. Cytoplasm. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Mainly cytoplasmic (PubMed:19703396, PubMed:25480299). Translocates into the cytoplasm following treatment of the cell with LPS (PubMed:16643855). Co-enriched in cytoplasmic foci with MOV10 (PubMed:30122351).
PMID: 16643855 by Minoda Y., et al. A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.
PMID: 18172165 by Mullen T.E., et al. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.