TUT4 Antibodies

AND TUT4 ELISA kits, TUT4 Proteins

Many biological assays use antibodies to detect TUT4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TUT4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TUT4 antibodies...

We validate the specificity of these antibodies to TUT4 by testing them on tissues known to express TUT4 positively and negatively. Browse below to find the TUT4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TUT4 Infographic by Boster Bio

All TUT4 Products

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Anti-ZCCHC11 TUT4 Antibody

Western blot analysis of extracts of 293T cells, using ZCCHC11 Antibody at 1:3000 dilution

Immunofluorescence analysis of U2OS cells using ZCCHC11 Rabbit pAb at dilution of 1:100

Immunofluorescence analysis of L929 cells using ZCCHC11 Rabbit pAb at dilution of 1:100

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A32031
100ul

TUT4 Overview

Facts about Terminal uridylyltransferase 4.

TUT4 3D structure. Source: alphafold

Terminal uridylyltransferase 4 (TUT4)

Uridylyltransferase that mediates the terminal uridylation of mRNAs with brief (less than 25 nucleotides) poly(A) tails, hence facilitating international mRNA decay (PubMed:25480299). During 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity).

Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 distinct uridylation mechanics (PubMed:25979828).

Gene Information

Human
Gene Name:	TUT4
Uniprot:	Q5TAX3
Entrez:	23318

Family

Belongs to:

DNA polymerase type-B-like family

Alternative Names

Terminal uridylyltransferase 4

Molecular Weight

Mass (kDA):
185.166 kDA

Genomic Context


Human

Location:	1p32.3
Sequence:	1; NC_000001.11 (52423275..52553463, complement)

Subcellular Localizations

Nucleus. Cytoplasm. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Mainly cytoplasmic (PubMed:19703396, PubMed:25480299). Translocates into the cytoplasm following treatment of the cell with LPS (PubMed:16643855). Co-enriched in cytoplasmic foci with MOV10 (PubMed:30122351).

Interacting Proteins

TIFA

PTMs

Methylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TUT4

References

PMID: 16643855 by Minoda Y., et al. A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.

PMID: 18172165 by Mullen T.E., et al. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.