UBASH3A Antibodies

AND UBASH3A ELISA kits, UBASH3A Proteins

Many biological assays use antibodies to detect UBASH3A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBASH3A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBASH3A antibodies...

We validate the specificity of these antibodies to UBASH3A by testing them on tissues known to express UBASH3A positively and negatively. Browse below to find the UBASH3A antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UBASH3A Infographic by Boster Bio

All UBASH3A Products

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Anti-UBASH3A Antibody

Western blot (WB) analysis of UBASH3A polyclonal antibody at 1:500 dilution
Lane1:HEK293T cell lysate
Lane2:sp2/0 cell lysate
Lane3:H9C2 cell lysate

Human, Mouse, Rat

ICC, WB

$405
Cat # A10433
100ul

UBASH3A (NM_001001895) Human Recombinant Protein

Coomassie blue staining of purified UBASH3A protein

$1062
Cat # PROTP57075
20 µg

Anti-UBASH3A Mouse Monoclonal Antibody [Clone ID: OTI4H1]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY UBASH3A (Right lane) cDNA for 48 hrs and lysed

Human

$523
Cat # M10433
100 µl

UBASH3A (NM_018961) Human Over-expression Lysate

UBASH3A Human Over-expression Lysates NM_001001895

Human

$628
Cat # LS053347
20 µg, 100 µg

UBASH3A Overview

Facts about Ubiquitin-associated and SH3 domain-containing protein A.

UBASH3A 3D structure. Source: alphafold

Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A)

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface.

Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation.

Gene Information

Human
Gene Name:	UBASH3A
Uniprot:	P57075
Entrez:	53347

Family

Belongs to:

No superfamily

Alternative Names

Cbl-interacting protein 4; gene similar to UBA containing SH3 domain10CLIP4STS-2T-cell ubiquitin ligand protein; STS2; Suppressor of T-cell receptor signaling 2; T-cell ubiquitin ligand; TULAubiquitin-associated and SH3 domain-containing protein A; ubiquitin associated and SH3 domain containing A

Molecular Weight

Mass (kDA):
74.123 kDA

Genomic Context


Human

Location:	21q22.3
Sequence:	21; NC_000021.9 (42403880..42447684)

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Diabetes Mellitus
Diabetes Mellitus, Insulin-dependent
Autoimmunity
Autoimmune Reaction
Autoimmune Diseases
Dysequilibrium Syndrome
Complete Hearing Loss
Gastritis, Atrophic
Graves Disease
Melanoma
Hypopigmentation Disorder
Down Syndrome

Tissue Adhesions
Erythropoietic Protoporphyria
Gastritis
Arthritis
Obesity
Lupus Erythematosus, Systemic
Achromia Of Skin

Interacting Proteins

CBS
DAZAP2
KRT40
REL
SF3B4

SPRY2
TRIM37

Pathways

Methylation
Dna Methylation
Pathogenesis
Localization

PTMs

Phosphorylation

Methylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBASH3A

References

PMID: 11281453 by Wattenhofer M., et al. Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains.

PMID: 15107835 by Feshchenko E.A., et al. TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.