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- Table of Contents
Facts about E3 UFM1-protein ligase 1.
May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784).
Human | |
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Gene Name: | UFL1 |
Uniprot: | O94874 |
Entrez: | 23376 |
Belongs to: |
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UFL1 family |
E3 UFM1-protein ligase 1; EC 6.3.2.-; KIAA0776; LZAP-binding protein; NLBPnovel LZAP-binding protein; RP3-393D12.1; UFL1
Mass (kDA):
89.595 kDA
Human | |
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Location: | 6q16.1 |
Sequence: | 6; NC_000006.12 (96521806..96555276) |
Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such Hep-G2, Hep 3B2.1-7, HLE and PLC.
Endoplasmic reticulum. Cytoplasm, cytosol.
PMID: 20531390 by Shiwaku H., et al. Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.
PMID: 20018847 by Tatsumi K., et al. A novel type of E3 ligase for the Ufm1 conjugation system.