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- Table of Contents

Facts about Zinc finger protein ZIC 2.
Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual goals. Its transcriptional activity is repressed by MDFIC.
| Human | |
|---|---|
| Gene Name: | ZIC2 |
| Uniprot: | O95409 |
| Entrez: | 7546 |

| Belongs to: |
|---|
| GLI C2H2-type zinc-finger protein family |

HPE5Zic family member 2 (odd-paired Drosophila homolog); Zic family member 2 (odd-paired homolog, Drosophila); Zinc finger protein of the cerebellum 2; zinc finger protein ZIC 2
Mass (kDA):
55.006 kDA

| Human | |
|---|---|
| Location: | 13q32.3 |
| Sequence: | 13; NC_000013.11 (99981784..99986765) |
Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity).





PMID: 9771712 by Brown S.A., et al. Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired.
PMID: 10984499 by Yang Y., et al. ZIC2 and Sp3 repress Sp1-induced activation of the human D1A dopamine receptor gene.