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Product Info Summary
| SKU: | AR1160 |
|---|---|
| Size: | 500T |
Product info
Product Overview
| Form | Liquid |
|---|---|
| Size | 5 mL (for 500 assays, 10μL per well) |
| Concentration | 6mg/ml |
| Buffer | 9% NaCl |
| Storage | Upon receipt store at -4°C, protect from light. Note: Repeated thawing and freezing causes an increase in the background, which interferes with the assay. |
| Stability | When stored as directed, product should be stable for one year. Store it at -20˚C for longer storage |
| Sensitivity | CCK-8 is the highest sensitive dye for the cell based assay. |
| Equivalent | Dojindo Molecular Technologies (Product No. CK04);
Millipore Sigma (Product No. 96992) |
Introduction
Cell Counting Kit-8 (CCK-8) allows very convenient assays by utilizing highly water-soluble tetrazolium salt. WST-8 [2- (2- methoxy-4-nitrophenyl)-3- (4-nitrophenyl)-5- (2, 4-disulfophenyl)-2H- tetrazolium, monosodium salt]* produces a water-soluble formazan dye upon reduction in the presence of an electron carrier. Cell Counting Kit-8 is a one-bottle solution; no premixing of components is required. Cell Counting Kit-8, being nonradioactive, allows sensitive colorimetric assays for the determination of the number of viable cells in cell proliferation cytotoxicity assays. WST-8 is reduced by dehydrogenases in cells to give an orange colored product (formazan), which is soluble in the tissue culture medium. The amount of the formazan dye generated by the activity of dehydrogenases in cells is directly proportional to the number of living cells. The cell proliferation assay using CCK-8 correlates well with the [ (3)H] thymidine incorporation assay. And the CCK-8 assay can also be substituted for the [ (3)H]thymidine incorporation assay. The detection sensitivity of CCK-8 is higher than other tetrazolium salts such as MTT, XTT, MTS or WST-1.
Advantages
1. One bottle, ready to use solution.
2. No organic solvents or isotopes required
3. No harvesting, no washing and no solubilization steps.
4. No Toxicity to Cell
5. More sensitive than MTT, XTT, MTS or WST-1
Precautions
1. Run pilot test to determine the optimal cell number and incubation time.
2. Since the CCK-8 assay is based on the dehydrogenase activity detection in viable cells, conditions or chemicals that affect dehydrogenase activity in viable cells may cause discrepancy between the actual viable cell number and the cell number determined using the CCK-8 assay.
3. WST-8 may react with reducing agents to generate WST-8 formazan. Please check the background O.D. if reducing agents are used in cytotoxicity assays or cell proliferation assays.
4. Be careful not to introduce bubbles to the wells, since they interfere with the O.D. reading.
5. Phenol red containing culture media can be used with this kit for cell viability assays.
6. Membrane filtration is recommended for the sterilization of the CCK-8 solution, if necessary.
7.The incubation time varies by the type and number of cells in a well. Generally, leukocytes give weak coloration, thus a long incubation time (up to 4 hours) or a large number of cells (~105 cells/well) may be necessary.
8. Since the cytotoxicity of this kit is very low, further color development is possible after reading the absorbance.
9.Neutral red or crystal violet can be used after the CCK-8 assay.
10.Measure the reference wavelength at 600 nm or higher if there is a high turbidity in the cell suspension.
Additional Materials Required
10μL and 100-200μL Multichannel Pipettes
Plate reader (450 nm filter)
96-well plate
CO2 incubator
General Protocol
Cell Number Determination
1. Inoculate cell suspension (100μL/well) in a 96-well plate. Pre-incubate the plate in a humidified incubator (e.g., at 37 ˚C, 5% CO2).
2. Add 10μL of the CCK-8 solution to each well of the plate. Be careful not to introduce bubbles to the wells, since they interfere with the O.D. reading.
3. Incubate the plate for 1-4 hours in the incubator.
4.Measure the absorbance at 450 nm using a microplate reader. To measure the absorbance later, add 10μL of 1% w/v SDS or 0.1M HCl to each well, cover the plate and store it with protection from light at room temperature. No absorbance change should be observed for 24 hours.
Cell proliferation and Cytotoxicity Assay
1. Dispense 100μL of cell suspension (5000 cells/well) in a 96- well plate. Pre-incubate the plate for 24 hours in a humidified incubator (e.g., at 37 ˚C, 5% CO2).
2. Add 10μL of various concentrations of substances to be tested to the plate.
3. Incubate the plate for an appropriate length of time (e.g., 6, 12, 24 or 48 hours) in the incubator.
4. Add 10μL of CCK-8 solution to each well of the plate. Be careful not to introduce bubbles to the wells, since they interfere with the O.D. reading.
5. Incubate the plate for 1-4 hours in the incubator.
6. Measure the absorbance at 450 nm using a microplate reader. To measure the absorbance later, add 10μL of 1% w/v SDS or 0.1M HCl to each well, cover the plate and store it with protection from light at room temperature. No absorbance change should be observed for 24 hours.
Frequently Asked Questions
1. How many cells should there be in a well?
For adhesive cells, at least 1000 cells are necessary per well (100μL medium). For leukocytes, at least 2500 cells are necessary per well (100μL medium) because of low sensitivity. The recommended maximum number of cells per well for the 96-well plate is 25000. If a 24 well or 6 well plate is used for this assay, please calculate the number of cells per well accordingly, and adjust the volume of the CCK-8 solution in a well to 10% of the total volume.
2. Does CCK-8 stain viable cells?
No. Since WST-8 and its formazan dye are highly water-soluble, CCK-8 cannot be utilized for cell staining purpose.
3. Does phenol red affect the assay?
No. The absorption value of phenol red in a culture medium can be removed by subtracting the absorption value of a blank solution from the absorption value of each well. Therefore, a medium containing phenol red is usable for the CCK-8 assay.
4. Is CCK-8 toxic to cells?
Since the toxicity of CCK-8 is so low, the same cells can be used for other cell proliferation assays such as the crystal violet assay, neutral red assay or DNA fluorometric assay after the CCK-8 assay is completed.
5. I do not have a 450 nm filter. What other filters can I use?
You can use filters with the absorbance between 430 and 490 nm, even though 450 nm filter gives the best sensitivity.
Product Images
Validation Images & Assay Conditions
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Figure 1. Absorption spectrum of WST-8 formazan
Figure 1 shows the absorption spectrum of WST-8 formazan. Since the absorbance at 460 nm is proportional to the number of viable cells in the medium, the viable cell number can be determined using the absorbance of a previously prepared calibration curve.
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Figure 2. Cell proliferation assay using CCK-8
Culture medium: MEM, 10% FBS
Incubation: 37 ℃, 5% CO2, 2 hours
Deteactin: 450nm
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Figure 3. Toxicological test of chemicals using CCK-8
Cell line: hela
Medium: DMEM, 10% FBS Chemicals: 200 μM Cisplatin (DDP)
Incubation: 37°C, 5% CO2, 2 hours
Specific Publications For AR1160
AR1160 has been cited in 511 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Period 3, a tumor suppressor in non-small cell lung cancer, is silenced by hypermethylation
TBL1XR1 promotes migration and invasion in osteosarcoma cells and is negatively regulated by miR-186-5p
MiR-491-5p negatively regulates cell proliferation and motility by targeting PDGFRA in prostate cancer
Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H2O2-induced premature senescence through SIRT1
Chikusetsu saponin IVa attenuates isoflurane-induced neurotoxicity and cognitive deficits via SIRT1/ERK1/2 in developmental rats
Demethylation of miR-10b plays a suppressive role in ccRCC cells
microRNA-106a induces the proliferation and apoptosis of glioma cells through regulating JNK/MAPK pathway
Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway
Iron Oxide Nanoparticles Promote Cx43-Overexpression of Mesenchymal Stem Cells for Efficient Suicide Gene Therapy during Glioma Treatment
Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation
Cartilage repair mediated by thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis
MiR-195-5p is a Potential Factor Responsible for CPNE1 Differential Expression between Subtypes of Non-Small Cell Lung Cancer
Effect of CELSR3 on the Cell Cycle and Apoptosis of Hepatocellular Carcinoma Cells
DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity
HSH2D contributes to methotrexate resistance in human T‑cell acute lymphoblastic leukaemia
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway
Catalpol‑mediated microRNA‑34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer
Downregulation of cytokeratin 18 enhances BCRP-mediated multidrug resistance through induction of epithelial-mesenchymal transition and predicts poor prognosis in breast cancer
Farnesoid X receptor inhibits proliferation of human colorectal cancer cells via the miR‑135A1/CCNG2 signaling pathway
HDAC6 inhibition suppresses chondrosarcoma by restoring the expression of primary cilia
HIF-1α inhibition sensitizes pituitary adenoma cells to temozolomide by regulating MGMT expression
Expression levels and associations of five long non‑coding RNAs in gastric cancer and their clinical significance
miR‑16 regulates proliferation and apoptosis of pituitary adenoma cells by inhibiting HMGA2
Lentiviral vector‑mediated IL‑9 overexpression stimulates cell proliferation by targeting c‑myc and cyclin D1 in colitis‑associated cancer
Expression of cold‑inducible RNA‑binding protein (CIRP) in renal cell carcinoma and the effect of CIRP downregulation cell proliferation and chemosensitivity to gemcitabine
IL‑8 is upregulated in cervical cancer tissues and is associated with the proliferation and migration of HeLa cervical cancer cells
Inhibition of autophagy potentiates the proliferation inhibition activity of microRNA‑7 in human hepatocellular carcinoma cells
Downregulation of HIF-1α inhibits the proliferation and invasion of non-small cell lung cancer NCI-H157 cells
Characterization of side population cells isolated from the gastric cancer cell line SGC-7901
microRNA-21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid endometrial cancer
ZEB1 promotes tumorigenesis and metastasis in hepatocellular carcinoma by regulating the expression of vimentin
MicroRNA‑4500 suppresses tumor progression in non‑small cell lung cancer by regulating STAT3
Kaempferol inhibits interleukin‑1β stimulated matrix metalloproteinases by suppressing the MAPK‑associated ERK and P38 signaling pathways
Fucoidan modulates cytokine production and migration of THP‑1‑derived macrophages via colony‑stimulating factor‑1
Effects of cisplatin on the LSD1-mediated invasion and metastasis of prostate cancer cells
Apigenin inhibits glioma cell growth through promoting microRNA-16 and suppression of BCL-2 and nuclear factor-κB/MMP‑9
Evodiamine sensitizes BGC-823 gastric cancer cells to radiotherapy in vitro and in vivo
SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α
Amiloride inhibits osteoclastogenesis by suppressing nuclear factor-κB and mitogen-activated protein kinase activity in receptor activator of nuclear factor-κB-induced RAW264.7 cells
High expression of Copine 1 promotes cell growth and metastasis in human lung adenocarcinoma
High C-X-C motif chemokine 5 expression is associated with malignant phenotypes of prostate cancer cells via autocrine and paracrine pathways
Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress
Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer
Ginsenoside Rh2 inhibits HeLa cell energy metabolism and induces apoptosis by upregulating voltage‑dependent anion channel 1
Simvastatin inhibits the adipogenesis of bone marrow‑derived mesenchymal stem cells through the downregulation of chemerin/CMKLR1 signaling
MicroRNA‑145‑5p inhibits osteosarcoma cell proliferation by targeting E2F transcription factor 3
MicroRNA‑137 suppresses the proliferation, migration and invasion of cholangiocarcinoma cells by targeting WNT2B
Upregulated ATF6 contributes to chronic intermittent hypoxia-afforded protection against myocardial ischemia/reperfusion injury
Total ginsenosides induce autophagic cell death in cervical cancer cells accompanied by downregulation of bone marrow stromal antigen‑2
HSP70 silencing aggravates apoptosis induced by hypoxia/reoxygenation in vitro
Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1 - induced inflammation
Long non-coding RNA highly up-regulated in liver cancer promotes exosome secretion
miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-β/Smad4 pathway
Basic Transcription Factor 3 Is Required for Proliferation and Epithelial–Mesenchymal Transition via Regulation of FOXM1 and JAK2/STAT3 Signaling in Gastric Cancer
Induction of the Unfolded Protein Response during Bovine Alphaherpesvirus 1 Infection
Chitosan-Based Microparticles Enhance Ellagic Acid’s Colon Targeting and Proapoptotic Activity
Comparison of the Partial Structure and Antioxidant Activity of Polysaccharides from Two Species of Chinese Truffles
Effects of Ultrasonic-Assisted Extraction on the Yield and the Antioxidative Potential of Bergenia emeiensis Triterpenes
Phenolic Composition, Antioxidant and Anticancer Potentials of Extracts from Rosa banksiae Ait. Flowers
20(S)-Ginsenoside Rg3 Promotes HeLa Cell Apoptosis by Regulating Autophagy
Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity
A Fibrin Coating Method of Polypropylene Meshes Enables the Adhesion of Menstrual Blood-Derived Mesenchymal Stromal Cells: A New Delivery Strategy for Stem Cell-Based Therapies
TNF-α-Induced VEGF and MMP-9 Expression Promotes Hemorrhagic Transformation in Pituitary Adenomas
High-Capacity Adenoviral Vectors Permit Robust and Versatile Testing of DMD Gene Repair Tools and Strategies in Human Cells
Eplerenone Reverses Cardiac Fibrosis via the Suppression of Tregs by Inhibition of Kv1.3 Channel
Protective Effect of Dictyophora Polysaccharides on Sodium Arsenite-Induced Hepatotoxicity: A Proteomics Study
Rhoifolin Ameliorates Osteoarthritis via Regulating Autophagy
The Analyses of Chemical Components From Oldenlandia hedyotidea (DC.) Hand.-Mazz and Anticancer Effects in vitro
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss
Chidamide Inhibits Acute Myeloid Leukemia Cell Proliferation by lncRNA VPS9D1-AS1 Downregulation via MEK/ERK Signaling Pathway
PPARα Ameliorates Doxorubicin-Induced Cardiotoxicity by Reducing Mitochondria-Dependent Apoptosis via Regulating MEOX1
Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss
PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells
Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways
Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes
Ulinastatin Inhibits Osteoclastogenesis and Suppresses Ovariectomy-Induced Bone Loss by Downregulating uPAR
Hypoxia-Related Gene FUT11 Promotes Pancreatic Cancer Progression by Maintaining the Stability of PDK1
Programmed Cell Death 10 Mediated CXCL2-CXCR2 Signaling in Regulating Tumor-Associated Microglia/Macrophages Recruitment in Glioblastoma
Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss
MiR-155 targeting FoxO3a regulates oral cancer cell proliferation, apoptosis, and DDP resistance through targeting FoxO3a
Upregulation of ITGBL1 predicts poor prognosis and promotes chemoresistance in ovarian cancer
Effect of Combined Sorafenib/Cisplatinum Treatment on the Autophagy and Proliferation of Hepatocellular Carcinoma hepG2 Cells in Vitro
Mechanism of RET gene mediated EGFR signaling pathway on epithelial-mesenchymal transition, proliferation and apoptosis of papillary thyroid carcinoma cells.
LncRNA MEG3 inhibits proliferation and promotes apoptosis of osteosarcoma cells through regulating Notch signaling pathway.
Increasing miR-150 and lowering HMGA2 inhibit proliferation and cycle progression of colon cancer in SW480 cells.
Poly(dopamine) and Ag nanoparticle-loaded TiO2 nanotubes with optimized antibacterial and ROS-scavenging bioactivities
Multi-omics analysis to identify driving factors in colorectal cancer
MiR-935/HIF1α Feedback Loop Inhibits the Proliferation and Invasiveness of Glioma
FANCI Cooperates with IMPDH2 to Promote Lung Adenocarcinoma Tumor Growth via a MEK/ERK/MMPs Pathway
Bag-1 Silence Sensitizes Non-Small Cell Lung Cancer Cells To Cisplatin Through Multiple Gene Pathways
ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma
miR-517a promotes Warburg effect in HCC by directly targeting FBP1
Single peptide ligand-functionalized uniform hollow mesoporous silica nanoparticles achieving dual-targeting drug delivery to tumor cells and angiogenic blood vessel cells
Synthesis Of PEG-Coated, Ultrasmall, Manganese-Doped Iron Oxide Nanoparticles With High Relaxivity For T1/T2 Dual-Contrast Magnetic Resonance Imaging
Long-lasting bactericidal activity through selective physical puncture and controlled ions release of polydopamine and silver nanoparticles–loaded TiO2 nanorods in vitro and in vivo
Development of dual delivery antituberculotic system containing rifapentine microspheres and adipose stem cells seeded in hydroxyapatite/tricalcium phosphate
Circular RNA Circ_0006282 Promotes Cell Proliferation and Metastasis in Gastric Cancer by Regulating MicroRNA-144-5p/Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein β Axis
Circ_0032821 Facilitates Gastric Cancer Cell Proliferation, Migration, Invasion and Glycolysis by Regulating MiR-1236-3p/HMGB1 Axis
HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells
Genetically modified endothelial progenitor cells with hNotch1.ICN overexpression display facilitated angiogenesis
4,4′-diaponeurosporene, a C30 carotenoid, effectively activates dendritic cells via CD36 and NF-κB signaling in a ROS independent manner
IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells
MicroRNA-205 targets SMAD4 in non-small cell lung cancer and promotes lung cancer cell growth in vitro and in vivo
GPR30-mediated HMGB1 upregulation in CAFs induces autophagy and tamoxifen resistance in ERα-positive breast cancer cells
Alisol A 24-acetate protects against brain microvascular endothelial cells injury through inhibiting miR-92a-3p/tight junctions axis
Two reactive behaviors of chondrocytes in an IL-1β-induced inflammatory environment revealed by the single-cell RNA sequencing
The circRNA circIFI30 promotes progression of triple-negative breast cancer and correlates with prognosis
Immune profiling reveals prognostic genes in high-grade serous ovarian cancer
PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission
Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis
H2S restores the cardioprotective effects of ischemic post-conditioning by upregulating HB-EGF/EGFR signaling
CircHIPK3/miR-381-3p axis modulates proliferation, migration, and glycolysis of lung cancer cells by regulating the AKT/mTOR signaling pathway
Circ-SFMBT2 facilitates the malignant growth of acute myeloid leukemia cells by modulating miR-582-3p/ZBTB20 pathway.
Proteomics analysis of chicken peripheral blood lymphocyte in Taishan Pinus massoniana pollen polysaccharide regulation
SATB1 Overexpression Regulates the Development and Progression in Bladder Cancer through EMT
Overexpression of Wip1 Is Associated with Biologic Behavior in Human Clear Cell Renal Cell Carcinoma
Actein Inhibits Cell Proliferation and Migration in Human Osteosarcoma
Eudragit S100-Coated Chitosan Nanoparticles Co-loading Tat for Enhanced Oral Colon Absorption of Insulin
The long non-coding RNA H19 induces hypoxia/reoxygenation injury by up-regulating autophagy in the hepatoma carcinoma cells
Involvement of endothelial CK2 in the radiation induced perivascular resistant niche (PVRN) and the induction of radioresistance for non-small cell lung cancer (NSCLC) cells
Hydrogel-hydroxyapatite-monomeric collagen type-I scaffold with low-frequency electromagnetic field treatment enhances osteochondral repair in rabbits
Effects of electromagnetic fields treatment on rat critical-sized calvarial defects with a 3D-printed composite scaffold
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway
The combinatory effect of sinusoidal electromagnetic field and VEGF promotes osteogenesis and angiogenesis of mesenchymal stem cell-laden PCL/HA implants in a rat subcritical cranial defect
The legacy effects of electromagnetic fields on bone marrow mesenchymal stem cell self-renewal and multiple differentiation potential
Ipriflavone attenuates the degeneration of cartilage by blocking the Indian hedgehog pathway
CPNE1 is a target of miR-335-5p and plays an important role in the pathogenesis of non-small cell lung cancer
Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes tumorigenesis and metastasis by targeting miR-199a/b-5p in hepatocellular carcinoma
Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds
Ginsenoside Rh2 represses autophagy to promote cervical cancer cell apoptosis during starvation
CircSEC24A upregulates TGFBR2 expression to accelerate pancreatic cancer proliferation and migration via sponging to miR-606
Starvation induced autophagy promotes the progression of bladder cancer by LDHA mediated metabolic reprogramming
Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis
Antisense oligonucleotides against microRNA-21 reduced the proliferation and migration of human colon carcinoma cells
Total flavones of Dracocephalum moldavica L. protect astrocytes against H 2 O 2 -induced apoptosis through a mitochondria-dependent pathway
Coreopsis tinctoria Nutt ameliorates high glucose-induced renal fibrosis and inflammation via the TGF-β1/SMADS/AMPK/NF-κB pathways
LINC02418 promotes malignant behaviors in lung adenocarcinoma cells by sponging miR-4677-3p to upregulate KNL1 expression
CircAGFG1 promotes cervical cancer progression via miR-370-3p/RAF1 signaling
Involvement of SLC39A6 in gastric adenocarcinoma and correlation of the SLC39A6 polymorphism rs1050631 with clinical outcomes after resection
CLASP2 is involved in the EMT and early progression after transurethral resection of the bladder tumor
The combined usage of Matrine and Osthole inhibited endoplasmic reticulum apoptosis induced by PCV2
Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis
Nanog down-regulates the Wnt signaling pathway via β-catenin phosphorylation during epidermal stem cell proliferation and differentiation
Clinical implications of AGBL2 expression and its inhibitor latexin in breast cancer
Long non-coding RNA PVT1 serves as a competing endogenous RNA for miR-186-5p to promote the tumorigenesis and metastasis of hepatocellular carcinoma:
8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway:
Preparation and characterization of conductive nerve guide conduit filled with dual drug-loaded nanofibers:
Calcium Channel Opening Rather than the Release of ATP Causes the Apoptosis of Osteoblasts Induced by Overloaded Mechanical Stimulation
Acacetin Protects Myocardial Cells against Hypoxia-Reoxygenation Injury through Activation of Autophagy
BMSC-Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR-326 Targeting HDAC3 and STAT1//NF-κB p65 to Chondrocytes
CircRNF13 Promotes the Malignant Progression of Pancreatic Cancer through Targeting miR-139-5p/IGF1R Axis
MiR-20a-5p Regulates MPP+-Induced Oxidative Stress and Neuroinflammation in HT22 Cells by Targeting IRF9/NF-κB Axis
Cyclophosphamide Attenuates Fibrosis in Lupus Nephritis by Regulating Mesangial Cell Cycle Progression
Protective Effects of Thalidomide on High-Glucose-Induced Podocyte Injury through In Vitro Modulation of Macrophage M1/M2 Differentiation
Shaoyao-Gancao Decoction Relieves Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome via Inactivating Transient Receptor Potential Vanilloid Type 1 and Reducing Serotonin Synthesis
Effects of Different Processed Products of Polygonum multiflorum on the Liver
Hydroxy-α-sanshool Possesses Protective Potentials on H2O2-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma
Thrombin Induces Secretion of Multiple Cytokines and Expression of Protease-Activated Receptors in Mouse Mast Cell Line
Oleic Acid Protects against Hepatic Ischemia and Reperfusion Injury in Mice by Inhibiting AKT/mTOR Pathways
Effects of Abnormal Savda Munzip on the Proliferation Activity and Migration Ability of Fibroblasts Derived from Hypertrophic Scar In Vitro
Stephania Tetrandra and Ginseng-Containing Chinese Herbal Formulation NSENL Reverses Cisplatin Resistance in Lung Cancer Xenografts
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety
Two Mutations in TP53 Promotes Migration, Invasion, and Proliferation of Human Ovarian Cancer A2780 Cells
Epstein-Barr Virus-Encoded Latent Membrane Protein 2A Downregulates GCNT3 via the TGF-β1/Smad-mTORC1 Signaling Axis
Anti‐inflammatory effect of paeoniflorin combined with baicalin in oral inflammatory diseases
Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus
Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy‐induced bone loss
PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer
The effects of human dermal–derived mesenchymal stem cells on the keratinocyte proliferation and apoptosis in psoriasis
MicroRNA‐126 deficiency enhanced the activation and function of CD4+T cells by elevating IRS‐1 pathway
Distinct roles of programmed death ligand 1 alternative splicing isoforms in colorectal cancer
An immunohistochemical study on endocrine cells in the neuroendocrine system of the digestive tract of milkfish Chanos chanos (Forsskal, 1775)
Anlotinib can overcome acquired resistance to EGFR‐TKIs via FGFR1 signaling in non‐small cell lung cancer without harboring EGFR T790M mutation
TRIAP1 knockdown sensitizes non‐small cell lung cancer to ionizing radiation by disrupting redox homeostasis
Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal‐regulated kinase signaling
Isoquercitrin protects against pulmonary hypertension via inhibiting PASMCs proliferation
Pyridostigmine ameliorates preeclamptic features in pregnant rats by inhibiting tumour necrosis factor-α synthetsis and antagonizing tumour necrosis factor-α-related effects
A Preliminary Study on the Effect and Mechanism of Breviscapine for Improving Insulin Resistance in HepG2 Cells
Long non-coding RNA HOTAIRM1 promotes proliferation and inhibits apoptosis of glioma cells by regulating the miR-873-5p/ZEB2 axis
Expression and prognostic value of brain and acute leukemia, cytoplasmic in meningiomas
Development of a Tetravalent T-Cell Engaging Bispecific Antibody Against Glypican-3 for Hepatocellular Carcinoma
DR1 activation promotes vascular smooth muscle cell apoptosis via up-regulation of CSE/H2S pathway in diabetic mice
REV-ERB agonism suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss partially via FABP4 upregulation
LncRNA NR_030777 Alleviates Paraquat-Induced Neurotoxicity by Regulating Zfp326 and Cpne5
Role of Cdc6 in re-replication in cells expressing human papillomavirus E7 oncogene
FBXL19-AS1 promotes cell proliferation and inhibits cell apoptosis via miR-876-5p/FOXM1 axis in breast cancer
Downregulation of Calbindin 1 by miR-454-3p Suppresses Cell Proliferation in Nonsmall Cell Lung Cancer In Vitro
Preparation and biological properties of silk fibroin/nano-hydroxyapatite/hyaluronic acid composite scaffold
Flexible and wearable sensor based on graphene nanocomposite hydrogels
Uniform iron oxide nanoparticles reduce the required amount of polyethylenimine in the gene delivery to mesenchymal stem cells
MicroRNA miR-30a inhibits cisplatin resistance in ovarian cancer cells through autophagy
CRTAC1 (Cartilage acidic protein 1) inhibits cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process in bladder cancer by downregulating Yin Yang 1 (YY1) to inactivate the TGF-β pathway
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5
LHPP inhibits hepatocellular carcinoma cell growth and metastasis
Aluminum maltolate triggers ferroptosis in neurons: mechanism of action
Two new organic acids from Portulaca oleracea L. and their anti-inflammatory and anticholinesterase activities
Alisol A 24-acetate protects oxygen–glucose deprivation-induced brain microvascular endothelial cells against apoptosis through miR-92a-3p inhibition by targeting the B-cell lymphoma-2 gene
Cyclodextrin metal-organic framework as vaccine adjuvants enhances immune responses
Green synthesis of gold nanoparticles from Dendrobium officinale and its anticancer effect on liver cancer
Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis
Macrophages as an active tumour-targeting carrier of SN38-nanoparticles for cancer therapy
The effect of ionizing radiation on the subcellular localization and kinase activity of protein kinase CK2 in human non-small cell lung cancer cells
PEI-modified diatomite/chitosan composites as bone tissue engineering scaffold for sustained release of BMP-2
5-Aminosalicylic acid inhibits inflammatory responses by suppressing JNK and p38 activity in murine macrophages
Inhibitory Effect of MicroRNA-107 on Osteosarcoma Malignancy Through Regulation of Wnt/β-catenin Signaling in Vitro
RANKL expression of primary osteoblasts is enhanced by an IL-17-mediated JAK2/STAT3 pathway through autophagy suppression
Insufficient ablation promotes the metastasis of residual non-small cell lung cancer (NSCLC) cells via upregulating carboxypeptidase A4
The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway
Overexpression of UHRF1 promoted the proliferation of vascular smooth cells via the regulation of Geminin protein levels
Phosphonate/zwitterionic/cationic terpolymer as high-efficiency bactericidal and antifouling coating for metallic substrates
Folic acid and deoxycholic acid derivative modified Fe3O4 nanoparticles for efficient pH-dependent drug release and multi-targeting against liver cancer cells
Multifunctional pathology-mapping theranostic nanoplatforms for US/MR imaging and ultrasound therapy of atherosclerosis
Preparation of antibacterial polypeptides with different topologies and their antibacterial properties
An enzyme-responsive and photoactivatable carbon-monoxide releasing molecule for bacterial infection theranostics
Plant sterol ester of α-linolenic acid ameliorates high-fat diet-induced nonalcoholic fatty liver disease in mice: association with regulating mitochondrial dysfunction and oxidative stress via activating AMPK signaling
Red blood cell membrane-coated upconversion nanoparticles for pretargeted multimodality imaging of triple-negative breast cancer
Rational design of a zwitterionic–phosphonic copolymer for the surface antifouling modification of multiple biomedical metals
Preparation and biological properties of silk fibroin/nano-hydroxyapatite/graphene oxide scaffolds with an oriented channel-like structure
One-step hydrophobization of tannic acid for antibacterial coating on catheters to prevent catheter-associated infections
Surface modification of porous PLGA scaffolds with plasma for preventing dimensional shrinkage and promoting scaffold–cell/tissue interactions
Enhanced oral absorption of insulin using colon-specific nanoparticles co-modified with amphiphilic chitosan derivatives and cell-penetrating peptides
Cu 2 (OH)PO 4 /reduced graphene oxide nanocomposites for enhanced photocatalytic degradation of 2,4-dichlorophenol under infrared light irradiation
Microwave-assisted facile synthesis of yellow fluorescent carbon dots from o-phenylenediamine for cell imaging and sensitive detection of Fe3+ and H2O2
Adipose stem cell-laden injectable thermosensitive hydrogel reconstructing depressed defects in rats: filler and scaffold
THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer
Ferromagnetic soft catheter robots for minimally invasive bioprinting
The regulation of CPNE1 ubiquitination by the NEDD4L is involved in the pathogenesis of non-small cell lung cancer
Reduced O-GlcNAcylation of SNAP-23 promotes cisplatin resistance by inducing exosome secretion in ovarian cancer
ARSD, a novel ERα downstream target gene, inhibits proliferation and migration of breast cancer cells via activating Hippo/YAP pathway
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis
PERK controls bone homeostasis through the regulation of osteoclast differentiation and function
Elevated DHODH expression promotes cell proliferation via stabilizing β-catenin in esophageal squamous cell carcinoma
The LXR-623-induced long non-coding RNA LINC01125 suppresses the proliferation of breast cancer cells via PTEN/AKT/p53 signaling pathway
Intravaginal Administration of Human Type III Collagen-Derived Biomaterial with High Cell-Adhesion Activity to Treat Vaginal Atrophy in Rats
Ultrasound-Mediated Long-Circulating Nanopolymer Delivery of Therapeutic siRNA and Antisense MicroRNAs Leads to Enhanced Paclitaxel Sensitivity in Epithelial Ovarian Cancer Chemotherapy
Surface-Adaptive and On-Demand Antibacterial Sponge for Synergistic Rapid Hemostasis and Wound Disinfection
Multifunctional Antibacterial Materials Comprising Water Dispersible Random Copolymers Containing a Fluorinated Block and Their Application in Catheters
Polyethylenimine Hybrid Thin-Shell Hollow Mesoporous Silica Nanoparticles as Vaccine Self-Adjuvants for Cancer Immunotherapy
Water-Insoluble Polymeric Guanidine Derivative and Application in the Preparation of Antibacterial Coating of Catheter
Self-Adaptive Antibacterial Coating for Universal Polymeric Substrates Based on a Micrometer-Scale Hierarchical Polymer Brush System
CNT/Sericin Conductive Nerve Guidance Conduit Promotes Functional Recovery of Transected Peripheral Nerve Injury in a Rat Model
Mn(II) Complex of Lipophilic Group-Modified Ethylenediaminetetraacetic Acid (EDTA) as a New Hepatobiliary MRI Contrast Agent
Structural Characterization and Immunostimulatory Activity of Polysaccharides from Brassica rapa L.
Angiotensin I-Converting Enzyme (ACE) Inhibitory and Antioxidant Activity of Umami Peptides after In Vitro Gastrointestinal Digestion
NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia/macrophages and mice models of spinal cord injury
PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation
Mechano-growth factor protects against mechanical overload induced damage and promotes migration of growth plate chondrocytes through RhoA/YAP pathway
Circular RNA circ_0029589 regulates proliferation, migration, invasion, and apoptosis in ox-LDL-stimulated VSMCs by regulating miR-424-5p/IGF2 axis
Expression of MAP9 in Epstein–Barr virus-associated gastric carcinoma
LMP1–miR-146a–CXCR4 axis regulates cell proliferation, apoptosis and metastasis
Epstein–Barr virus miRNA-BART16 modulates cell proliferation by targeting LMP1
MiR-BART1-5p targets core 2β-1,6-acetylglucosaminyltransferase GCNT3 to inhibit cell proliferation and migration in EBV-associated gastric cancer
Constitutive activation of the canonical NF-κB signaling pathway in EBV-associated gastric carcinoma
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study
Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission
Physcion 8-O-β-glucopyranoside exhibits anti-leukemic activity through targeting sphingolipid rheostat
Rapid synthesis of B-N co-doped yellow emissive carbon quantum dots for cellular imaging
miR-155 Accelerates the Growth of Human Liver Cancer Cells by Activating CDK2 via Targeting H3F3A
miR372 Promotes Progression of Liver Cancer Cells by Upregulating erbB-2 through Enhancement of YB-1
Inflammatory-Related P62 Triggers Malignant Transformation of Mesenchymal Stem Cells through the Cascade of CUDR-CTCF-IGFII-RAS Signaling
Psoriasis-associated angiogenesis is mediated by EDIL3
Novel probiotic-bound oxidized Bletilla striata polysaccharide-chitosan composite hydrogel
Poly(γ-glutamic acid)-based electrospun nanofibrous mats with photodynamic therapy for effectively combating wound infection
The electrostimulation and scar inhibition effect of chitosan/oxidized hydroxyethyl cellulose/reduced graphene oxide/asiaticoside liposome based hydrogel on peripheral nerve regeneration in vitro
Improvement of the immunogenicity of ESAT-6 via fusion with the dodecameric protein dodecin of Mycobacterium tuberculosis
Carboxymethyl chitosan/sodium alginate-based micron-fibers fabricated by emulsion electrospinning for periosteal tissue engineering
ITGA8 positive cells in the conventional outflow tissue exhibit Schlemms canal endothelial cell properties
Paracrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met/PI3K/Akt signaling in pancreatic cancer in vitro
Chondrocyte ferroptosis contribute to the progression of osteoarthritis
Icariin protects vascular endothelial cells from oxidative stress through inhibiting endoplasmic reticulum stress
Rational design of phosphonate/quaternary amine block polymer as an high-efficiency antibacterial coating for metallic substrates
Electrostatic assembly functionalization of poly (γ-glutamic acid) for biomedical antibacterial applications
Bilayered HA/CS/PEGDA hydrogel with good biocompatibility and self-healing property for potential application in osteochondral defect repair
Poly(hexamethylene biguanide) (PHMB) as high-efficiency antibacterial coating for titanium substrates
Daphnes Cortex and its licorice-processed products suppress inflammation via the TLR4/NF-κB/NLRP3 signaling pathway and regulation of the metabolic profile in the treatment of rheumatoid arthritis
The cold-soaking extract of Chinese yam (Dioscorea opposita Thunb.) protects against erectile dysfunction by ameliorating testicular function in hydrocortisone-induced KDS-Yang rats and in oxidatively damaged TM3 cells
Self-enriched mesoporous silica nanoparticle composite membrane with remarkable photodynamic antimicrobial performances
Optimization of ultrasound-assisted extraction of triterpenes from Bergenia emeiensis leaves and inhibition effect on the growth of Hela cells
Alpha-linolenic acid inhibits IgE-mediated anaphylaxis by inhibiting Lyn kinase and suppressing mast cell activation
Combined MEK inhibition and tumor-associated macrophages depletion suppresses tumor growth in a triple-negative breast cancer mouse model
Uniformly sized iron oxide nanoparticles for efficient gene delivery to mesenchymal stem cells
Involvement of exogenous H2S in recovery of cardioprotection from ischemic post-conditioning via increase of autophagy in the aged hearts
Structure and immunomodulatory activity of a water-soluble α-glucan from Hirsutella sinensis mycelia
Sulfated modification, characterization, immunomodulatory activities and mechanism of the polysaccharides from Cyclocarya paliurus on dendritic cells
Characteristics and bioactivities of different molecular weight polysaccharides from camellia seed cake
Influence of glucose transporter 1 activity inhibition on neuroblastoma in vitro
Three novel alkaloids from Portulaca oleracea L. and their anti-inflammatory bioactivities
A new skeleton flavonoid and a new lignan from Portulaca oleracea L. and their activities
Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138–5p/SLC7A5 axis
Salidroside attenuates CoCl2-simulated hypoxia injury in PC12 cells partly by mitochondrial protection
Protective effects of Erdosteine on interleukin-1β-stimulated inflammation via inhibiting the activation of MAPK, NF-κB, and Wnt/β-catenin signaling pathways in rat osteoarthritis
Liquiritigenin inhibits IL-1β-induced inflammation and cartilage matrix degradation in rat chondrocytes
MiR-140-5p/TLR4 /NF-κB signaling pathway: Crucial role in inflammatory response in 16HBE cells induced by dust fall PM2.5
Heparanase-driven inflammation from the AGEs-stimulated macrophages changes the functions of glomerular endothelial cells
Osseointegration and biosafety of graphene oxide wrapped porous CF/PEEK composites as implantable materials: The role of surface structure and chemistry
Short fluorocarbon chains containing hydrophobic nanofibrous membranes with improved hemocompatibility, anticoagulation and anti-fouling performance
Application of injectable silk fibroin/graphene oxide hydrogel combined with bone marrow mesenchymal stem cells in bone tissue engineering
Digital light processing porous TPMS structural HA & akermanite bioceramics with optimized performance for cancellous bone repair
Preparation and biological evaluation of ZrO2 all-ceramic teeth by DLP technology
Inhibition of PRMT5 suppresses osteoclast differentiation and partially protects against ovariectomy-induced bone loss through downregulation of CXCL10 and RSAD2
Preparation and characterization of feruloylated oat β-glucan with antioxidant activity and colon-targeted delivery
Mutation of the BAG-1 domain decreases its protective effect against hypoxia/reoxygenation by regulating HSP70 and the PI3K/AKT signalling pathway in SY-SH5Y cells
Biological activity of Brassica rapa L. polysaccharides on RAW264.7 macrophages and on tumor cells
Synthesis of novel 10-hydroxycamptothecin derivatives utilizing topotecan hydrochloride as ortho-quinonemethide precursor
Autophagy negative-regulating Wnt signaling enhanced inflammatory osteoclastogenesis from Pre-OCs in vitro
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss
Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K/Akt/mTOR pathway
Artemisinin, a potential option to inhibit inflammation and angiogenesis in rosacea
Caffeic acid protects against IL-1β-induced inflammatory responses and cartilage degradation in articular chondrocytes
Physcion 8-O-β-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis
Autophagy is a pro-survival mechanism in ovarian cancer against the apoptotic effects of euxanthone
Physcion induces apoptosis through triggering endoplasmic reticulum stress in hepatocellular carcinoma
Ossotide promotes cell differentiation of human osteoblasts from osteogenesis imperfecta patients by up-regulating miR-145
Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration
Novel gadopentetic acid-doped silica nanoparticles conjugated with YPSMA-1 targeting prostate cancer for MR imaging: an in vitro study
AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells
Preparation and characterization of ZrO2-Al2O3 bioceramics by stereolithography technology for dental restorations
Three-dimensional bioprinting of a full-thickness functional skin model using acellular dermal matrix and gelatin methacrylamide bioink
Tumor vascular homing endgolin-targeted radioimmunotherapy in hepatocellular carcinoma
Long non-coding RNA NEAT1 promotes lipopolysaccharide-induced acute lung injury by regulating miR-424-5p/MAPK14 axis
Fucoidan reduced the invasion of oral squamous cell carcinoma cells and modified their effects to macrophages
Pathways Involved in Oxygen Glucose Deprivation Damage of Astrocytes
The Immune Regulatory Effect of Boron on Ostrich Chick Splenic Lymphocytes
Effects of Boron on Cytotoxicity, Apoptosis, and Cell Cycle of Cultured Rat Sertoli Cells In vitro
Inhibition of cell proliferation and promotion of acinus-like structure formation from goat mammary epithelial cells via Wnt/β-catenin signaling
Anti-rheumatic drug iguratimod (T-614) alleviates cancer-induced bone destruction via down-regulating interleukin-6 production in a nuclear factor-κB-dependent manner
Overexpression of CXCL3 can enhance the oncogenic potential of prostate cancer
Neuroprotective Effects of Deuterium-Depleted Water (DDW) Against H 2 O 2 -Induced Oxidative Stress in Differentiated PC12 Cells Through the PI3K/Akt Signaling Pathway
Xanthohumol protects neuron from cerebral ischemia injury in experimental stroke
Constructing bio-functional layers of hyaluronan and type IV collagen on titanium surface for improving endothelialization
Effect of luteinizing hormone concentration on transcriptome and subcellular organelle phenotype of ovarian granulosa cells
Oridonin Attenuates TNBS-induced Post-inflammatory Irritable Bowel Syndrome via PXR/NF-κB Signaling
Isorhapontigenin Suppresses Interleukin-1β-Induced Inflammation and Cartilage Matrix Damage in Rat Chondrocytes
Icariine Restores LPS-Induced Bone Loss by Downregulating miR-34c Level
A Common Missense Variant in OMA1 Associated with the Prognosis of Heart Failure
Circ_0072995 Promotes Ovarian Cancer Progression Through Regulating miR-122-5p/SLC1A5 Axis
Caspase cleavage of Mcl-1 impairs its anti-apoptotic activity and proteasomal degradation in non-small lung cancer cells
Long non-coding RNA NEAT1 promotes lipopolysaccharide-induced injury in human tubule epithelial cells by regulating miR-93-5p/TXNIP axis
Mycobacteriumtuberculosis PE25/PPE41 protein complex induces activation and maturation of dendritic cells and drives Th2-biased immune responses
Fluorophenols bearing nitrogenated heterocycle moieties, a class of novel Keap1-Nrf2 protein-protein interaction inhibitors: synthesis, antioxidant stress screening and molecular docking
Synthesis and antitumor activity of pyrano[3,2- i ]-fused camptothecin derivatives
Mechanism of bone marrow mesenchymal stem cells secreting miR-26a exosomes affecting high glucose-induced skin fibroblasts function by regulating TLR4/NF-κB signaling
The regulation of Neuropilin 1 expression by miR‐338‐3p promotes non‐small cell lung cancer via changes in EGFR signaling
Synthesis and Thermoresponsive Properties of Biocompatible and Biodegradable Triblock Copolymers Bearing Linear or Y‐Shaped OEG Pendants
Latent membrane protein 2A inhibits expression level of Smad2 through regulating miR‐155‐5p in EBV‐associated gastric cancer cell lines
lncMGPF is a novel positive regulator of muscle growth and regeneration
YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration
CXCL3 overexpression promotes the tumorigenic potential of uterine cervical cancer cells via the MAPK/ERK pathway
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR‐335‐5p in non‐small cell lung cancer
Hesperetin suppresses RANKL‐induced osteoclastogenesis and ameliorates lipopolysaccharide‐induced bone loss
Icariin protects against iron overload‐induced bone loss via suppressing oxidative stress
Effects of microRNA‐217 on proliferation, apoptosis, and autophagy of hepatocytes in rat models of CCL4‐induced liver injury by targeting NAT2
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS‐induced oxidative stress and NF‐κB and MAPKs pathways activating
Inhibition of ACLY leads to suppression of osteoclast differentiation and function via regulation of histone acetylation
Paraquat and MPTP alter microRNA expression profiles, and downregulated expression of miR‐17‐5p contributes to PQ‐induced dopaminergic neurodegeneration
Upregulated lncRNA ADAMTS9‐AS2 suppresses progression of lung cancer through inhibition of miR‐223‐3p and promotion of TGFBR3
Integrated multi‐omics data analyses for exploring the co‐occurring and mutually exclusive gene alteration events in colorectal cancer
Epithelial cell adhesion molecule promotes breast cancer resistance protein‐mediated multidrug resistance in breast cancer by inducing partial epithelial–mesenchymal transition
The CTIP‐mediated repair of TNF‐α‐induced DNA double‐strand break was impaired by miR‐130b in cervical cancer cell
Downregulation of KIAA1199 by miR‐486‐5p suppresses tumorigenesis in lung cancer
MicroRNA‐4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non‐small cell lung cancer
The effect of electromagnetic fields on the proliferation and the osteogenic or adipogenic differentiation of mesenchymal stem cells modulated by dexamethasone
Physcion Synergistically Enhances the Cytotoxicity of Sorafenib in Hepatocellular Carcinoma
Synergistic Antibacterial and Anti‐Inflammatory Effects of a Drug‐Loaded Self‐Standing Porphyrin‐COF Membrane for Efficient Skin Wound Healing
Multifunctional [email protected](ethylene imine) Nanoplatforms for Imaging Guided Gene‐Photothermal Synergistic Therapy of Cancer
MicroRNA‐4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non‐small cell lung cancer
The effect of electromagnetic fields on the proliferation and the osteogenic or adipogenic differentiation of mesenchymal stem cells modulated by dexamethasone
Physcion Synergistically Enhances the Cytotoxicity of Sorafenib in Hepatocellular Carcinoma
Synergistic Antibacterial and Anti‐Inflammatory Effects of a Drug‐Loaded Self‐Standing Porphyrin‐COF Membrane for Efficient Skin Wound Healing
Multifunctional [email protected](ethylene imine) Nanoplatforms for Imaging Guided Gene‐Photothermal Synergistic Therapy of Cancer
MicroRNA‐4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non‐small cell lung cancer
The effect of electromagnetic fields on the proliferation and the osteogenic or adipogenic differentiation of mesenchymal stem cells modulated by dexamethasone
Physcion Synergistically Enhances the Cytotoxicity of Sorafenib in Hepatocellular Carcinoma
Synergistic Antibacterial and Anti‐Inflammatory Effects of a Drug‐Loaded Self‐Standing Porphyrin‐COF Membrane for Efficient Skin Wound Healing
Multifunctional [email protected](ethylene imine) Nanoplatforms for Imaging Guided Gene‐Photothermal Synergistic Therapy of Cancer
Cytochrome P450 2A6 is associated with macrophage polarization and is a potential biomarker for hepatocellular carcinoma
Down‐regulation of PDGFRβ suppresses invasion and migration in osteosarcoma cells by influencing epithelial–mesenchymal transition
MiR‐3175 promotes epithelial‐mesenchymal transition by targeting Smad7 in human conjunctiva and pterygium
MiR‐3175 promotes epithelial‐mesenchymal transition by targeting Smad7 in human conjunctiva and pterygium
The osteogenesis of bacterial cellulose scaffold loaded with bone morphogenetic protein-2
Fabrication of polylysine based antibacterial coating for catheters by facile electrostatic interaction
CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer
KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway
C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation
Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response
Clara cell 10-kDa protein inhibits TH17 responses through modulating dendritic cells in the setting of allergic rhinitis
Artificially Engineered Cubic Iron Oxide Nanoparticle as a High-Performance Magnetic Particle Imaging Tracer for Stem Cell Tracking
Lipocalin2 suppresses metastasis of colorectal cancer by attenuating NF-κB-dependent activation of snail and epithelial mesenchymal transition
Self‐Healing Silk Fibroin‐Based Hydrogel for Bone Regeneration: Dynamic Metal‐Ligand Self‐Assembly Approach
Yao X,Jing X,Guo J,Sun K,Deng Y,Zhang Y,Guo F,Ye Y.Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.Front Pharmacol.2019 Feb 28;10:163. doi:10.3389/fphar.2019.00163.PMID:30873034;PMCID:PMC6403125.
Species: Rat
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:BMSCS, DILUTION:NA
Li Q,Zong Y,Li K,Jie X,Hong J,Zhou X,Wu B,Li Z,Zhang S,Wu G,Meng R. Involvement of endothelial CK2 in the radiation induced perivascular resistant niche (PVRN) and the induction of radioresistance for non-small cell lung cancer (NSCLC) cells.Biol Res.2019 Apr 16;52(1):22. doi:10.1186/s40659-019-0231-x.PMID:30992075;PMCID:PMC6466699.
Species: Human
AR1160 usage in article: APP:CCK-8 ASSAY, SAMPLE:HUVECS, DILUTION:NA
Qu Y,Dou P,Hu M,Xu J,Xia W,Sun H.circRNA‑CER mediates malignant progression of breast cancer through targeting the miR‑136/MMP13 axis.Mol Med Rep.2019 Apr;19(4):3314-3320.doi:10.3892/mmr.2019.9965.Epub 2019 Feb 18.PMID:30816475.
Species: Human
AR1160 usage in article: APP:CELL PROLIFERATION ASSAY, SAMPLE:MCF-7 CELL AND ZR-75-30 CELL, DILUTION:NA
Yao X,Zhang J,Jing X,Ye Y,Guo J,Sun K,Guo F.Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission.Pharmacol Res.2019 Jan;139:314-324.doi:10.1016/j.phrs.2018.09.026.Epub 2018 Sep 28.PMID:30273654.
Species: Rat
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:CHONDROCYTES, DILUTION:NA
Li Q,Huang P,Chen W,Bi J.Mechanism of bone marrow mesenchymal stem cells secreting miR-26a exosomes affecting high glucose-induced skin fibroblasts function by regulating TLR4/NF-κB signaling.Inflamm Res.2021 Jun 29.doi:10.1007/s00011-021-01478-7.Epub ahead of print.PMID:34185112.
Species: Human
AR1160 usage in article: APP:CELL PROLIFERATION, SAMPLE:BJ CELL, DILUTION:NA
Qiang Wang,Yuan Wang,Feng Zhou,Jie Li,Gang Lu,Yingqian Zhao,"MiR-20a-5p Regulates MPP+-Induced Oxidative Stress and Neuroinflammation in HT22 Cells by Targeting IRF9/NF-κB Axis",Evidence-Based Complementary and Alternative Medicine,vol.2021,Article ID 6621206,9 pages,2021.https://doi.org/10.1155/2021/6621206
Species: Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:HT22 CELL, DILUTION:NA
Chong Liu,Minmin Zhang,Shenyi Ye,Chenliang Hong,Jiaxi Chen,Ruyue Lu,Bingjie Hu,Weijun Yang,Bo Shen,Zhengyi Gu,"Acacetin Protects Myocardial Cells against Hypoxia-Reoxygenation Injury through Activation of Autophagy",Journal of Immunology Research,vol.2021,Article ID 9979843,12 pages,2021.https://doi.org/10.1155/2021/9979843
Species: Rat
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:H9C2 CELL, DILUTION:NA
Yu L,Huang N,Ge L,Sun H,Fu Y,Liu C,Wang J.Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds.J Biol Eng.2021 Jun 29;15(1):18.doi:10.1186/s13036-021-00272-7.PMID:34187511;PMCID:PMC8243740.
Species: Human
AR1160 usage in article: APP:CELL PROLIFERATION ASSAY, SAMPLE:PBMCS, DILUTION:NA
Chao Hu,Xiaobin Zhu,Taogen Zhang,Zhouming Deng,Yuanlong Xie,Feifei Yan,Lin Cai," Tanshinone IIA Inhibits Osteosarcoma Growth through a Src Kinase-Dependent Mechanism",Evidence-Based Complementary and Alternative Medicine,vol.2021,Article ID 5563691,15 pages,2021.https://doi. org/10.1155/2021/5563691
Species: Human,Mouse
AR1160 usage in article: APP:CELL CYCLE ANALYSIS, SAMPLE:U2-OS CELL AND MG-63 CELL, DILUTION:NA
Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL.Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.Theranostics.2021 May 3;11(14):6668-6681.doi:10.7150/thno.56494.PMID:34093846; PMCID:PMC8171085.
Species: Mouse
AR1160 usage in article: APP:CYTOTOXICITY ASSAY, SAMPLE:B16 CELL AND AB12-LUC CELL, DILUTION:NA
Yuan J,Liu Y,Zhang Q,Ren Z,Li G,Tian R.CircPRDM2 Contributes to Doxorubicin Resistance of Osteosarcoma by Elevating EZH2 via Sponging miR-760.Cancer Manag Res.2021;13: 4433-4445https://doi.org/10.2147/CMAR.S295147
Species: Human,Mouse
AR1160 usage in article: APP:CCK-8 ASSAY, SAMPLE:OS CELL, DILUTION:NA
Fen Chen,Yaru Wu,Jiamin Wu,Hao Zhu,Shuang Chen,Shuaibin Hua,Zixuan He,Changyu Liu,Jun Xiao,Yusheng Shi,Preparation and characterization of ZrO2-Al2O3 bioceramics by stereolithography technology for dental restorations,Additive Manufacturing,2021,102055,ISSN 2214-8604,https://doi.org/10.1016/j.addma.2021.102055.
Species: Rat
AR1160 usage in article: APP:CELL PROLIFERATION, SAMPLE:RBMSCS, DILUTION:NA
Xiaoting Jin,Haiyi Yu,Ze Zhang et al.Surface Charge-Dependent Mitochondrial Response to Similar Intracellular Nanoparticle Contents at Sublethal Dosages,24 May 2021,PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-503848/v1]
Species: Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:RAW264.7 CELL, DILUTION:NA
Qian L,Yang X,Li S,Zhao H,Gao Y,Zhao S,Lv X,Zhang X,Li L,Zhai L,Zhou F,Chen B.Reduced O-GlcNAcylation of SNAP-23 promotes cisplatin resistance by inducing exosome secretion in ovarian cancer.Cell Death Discov.2021 May 18;7(1):112.doi:10.1038/s41420-021-00489-x.PMID:34001861.
Species: Human,Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:A2780 CELL AND SKOV3 CELL, DILUTION:NA
Qiu F,Zhang Z,Yang L,Li R,Ma Y.Combined effect of vitamin C and vitamin D3 on intestinal epithelial barrier by regulating Notch signaling pathway.Nutr Metab (Lond).2021 May 8;18(1):49.doi:10.1186/s12986-021-00576-x.PMID:33964955;PMCID:PMC8105975.
Species: Human,Dunkin–Hartley guinea pig
AR1160 usage in article: APP:CELL PROLIFERATION ASSAY, SAMPLE:SW480 CELL, DILUTION:NA
Yang J,Wu L,Liu S,Hu X,Wang Q,Fang L.Long non-coding RNA NEAT1 promotes lipopolysaccharide-induced injury in human tubule epithelial cells by regulating miR-93-5p/TXNIP axis.Med Microbiol Immunol.2021 Apr 22.doi:10.1007/s00430-021-00705-6.Epub ahead of print.PMID:33885954.
Species: Human
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:HK2 CELL, DILUTION:NA
Zhang H,Li M,Zhang J,Shen Y,Gui Q.Exosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis.Drug Des Devel Ther.2021 May 3;15:1835-1849.doi:10.2147/DDDT.S300376.PMID:33976535;PMCID:PMC8106459.
Species: Human,Mouse
AR1160 usage in article: APP:CELL COUNTING KIT-8 ASSAY, SAMPLE:PC-3 CELL, DILUTION:NA
Wang Y,Wang W,Yang X,Chen W,Yang X,Pan X,Xu P,Zhu W,Han Y,Chen X.ITGA8 positive cells in the conventional outflow tissue exhibit Schlemm‘s canal endothelial cell properties.Life Sci.2021 May 4:119564.doi:10.1016/j.lfs.2021.119564.Epub ahead of print.PMID:33961857.
Species: Human
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE: HTM CELL, DILUTION:NA
Zhao R,Luo T,Ma P,Ge L,Chen Z,Wang X,Liao W,Bao L.Improvement of the immunogenicity of ESAT-6 via fusion with the dodecameric protein dodecin of Mycobacterium tuberculosis.Microb Pathog.2021 Apr 26;155:104890.doi:10.1016/j.micpath.2021.104890.Epub ahead of print.PMID:33915207.
Species: Mouse
AR1160 usage in article: APP:CELL PROLIFERATION ASSAY, SAMPLE:SPLEEN LYMPHOCYTES, DILUTION:NA
Bian,S.,Zhao,Y.,Li,F.,Lu,S.,He,Z.,Wang,S. ...Wang,J.(2021).Total ginsenosides induce autophagic cell death in cervical cancer cells accompanied by downregulation of bone marrow stromal antigen‑2.Experimental and Therapeutic Medicine,22,667.https://doi.org/10.3892/etm.2021.10099
Species: Human
AR1160 usage in article: APP:CELL VIABILITY, SAMPLE:HELA CELL, DILUTION:NA
Cao Y,Wang Y,Xiao L,Xu JY,Liu Y,Jiang R,Li T,Jiang J.Endothelial-derived exosomes induced by lipopolysaccharide alleviate rat cardiomyocytes injury and apoptosis.Am J Transl Res.2021 Mar 15;13(3):1432-1444.PMID:33841668;PMCID:PMC8014340.
Species: Rat
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:CMS, DILUTION:NA
Pan, A., Li, Y., Guan, J., Zhang, P., Zhang, C., Han, Y. ... Wang, J. (2021). USP18‑deficiency in cervical carcinoma is crucial for the malignant behavior of tumor cells in an ERK signal‑dependent manner. Oncology Letters, 21, 421. https://doi.org/10.3892/ol. 2021.12682
Species: Human
AR1160 usage in article: APP:CELL PROLIFERATION ASSAY, SAMPLE:HELA CELL, DILUTION:NA
Zhang M, Cheng K. Long non-coding RNA KCNQ1OT1 promotes hydrogen peroxide-induced lens epithelial cell apoptosis and oxidative stress by regulating miR-223-3p/BCL2L2 axis. Exp Eye Res. 2021 Mar 17:108543. doi: 10.1016/j.exer.2021.108543. Epub ahead of print. PMID: 33744257.
Species: Human
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:SRA01/04 CELL, DILUTION:NA
Ji-ling Lv, Li-na Shi, Cong-ying Zhai, Ge-jin Wang, Yan Qu, "Bag-1L Protects against Cell Apoptosis in an In Vitro Model of Lung Ischemia-Reperfusion Injury through the C-Terminal “Bag” Domain", BioMed Research International, vol. 2021, Article ID 8822807, 13 pages, 2021. https://doi.org/10.1155/2021/8822807
Species: Human
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:A549 CELL, DILUTION:NA
Liu Hui,Zhou Chuankun,Qi Dahu,Gao Yutong,Zhu Meipeng,Tao Tenghui,Sun Xuying,Xiao Jun,Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss.Frontiers in Cell and Developmental Biology,VOLUME=9,YEAR=2021, PAGES=544, URL=https://www.frontiersin.org/article/10.3389/fcell.2021.640867. DOI=10.3389/fcell.2021.640867,ISSN=2296-634X
Species: Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:BONE MARROW MACROPHAGES, DILUTION:NA
Huang T,Luo X,Wu B,Peng P,Dai Y,Hu G,Qiu H,Yuan X.Pyrotinib enhances the radiosensitivity of HER2‑overexpressing gastric and breast cancer cells.Oncol Rep.2020 Dec;44(6):2634-2644.doi:10.3892/or.2020.7820.Epub 2020 Oct 21.PMID:33125154;PMCID:PMC7640366.
Species: Human,Mouse
AR1160 usage in article: APP:CELL VIABILITY, SAMPLE:GC CELL AND BC CELL, DILUTION:NA
Guo J,Ren R,Yao X,Ye Y,Sun K,Lin J,Wang G, Guo F,Xiao J,Xu T.PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission.Aging (Albany NY).2020 Feb 25;12(4):3976-3992.doi:10. 18632/aging
Species: Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:BMSCS, DILUTION:NA
Zhang R,Zhang Q,Zou Z,Li Z,Jin M,An J,Li H,Ma J.Curcumin Supplementation Enhances Bone Marrow Mesenchymal Stem Cells to Promote the Anabolism of Articular Chondrocytes and Cartilage Repair.Cell Transplant.2021 Jan-Dec;30:963689721993776.doi:10.1177/096368
Species: Rat
AR1160 usage in article: APP:CELL VIABILITY, SAMPLE:BMSCS, DILUTION:NA
Shao N,Song L,Sun X.Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis.Mol Cell Biochem.2021 Feb 11.doi:10.1007/s11010-021-04083-8.Epub ahead of print.PMID:33570734.
Species: Human,Mouse
AR1160 usage in article: APP:CELL VIABILITY, SAMPLE:A549 CELL AND H1299 CELL, DILUTION:NA
Chu X,Yu T,Huang X,Xi Y,Ni B,Zhang R,You H.Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats.Aging (Albany NY).2020 Jul 5;12(13):12799-12811.doi:10.18632/aging.103222.Epub 2020
Species: Rat
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:PRIMARY CHONDROCYTES, DILUTION:NA
Shuai Bian,Yue Zhao,Fangyu Li,Shuyan Lu,Song Yang,Meichen Liu,Siming Wang,Daqing Zhao,Wei Zhang,Jiawen Wang,Knockdown of p62/sequestosome enhances ginsenoside Rh2-induced apoptosis in cervical cancer HeLa cells with no effect on autophagy,Bioscience,Biote
Species: Human
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:HELA CELL, DILUTION:NA
Wenpeng Cao,Zhirui Zeng,Zhiwei He et al.Hypoxia-Related Gene FUT11 Promoted Pancreatic Cancer Progression Via Maintaining The Stabilization of PDK1,27 January 2021,PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-152464/
Species: Human,Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:PANC-1 CELL AND ASPC-1 CELL, DILUTION:NA
Hua Y, Wang H, Wang H, Wu X, Yang L, Wang C, Li X, Jin Y, Li M, Wang L, Dong C, Yin F. Circular RNA Circ_0006282 Promotes Cell Proliferation and Metastasis in Gastric Cancer by Regulating MicroRNA-144-5p/Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase
Species: Human
AR1160 usage in article: APP:CELL PROLIFERATION ASSAY, SAMPLE:AGS CELL AND HGC-27 CELL, DILUTION:NA
Liu Y,Liu W,Zhang Z,Hu Y,Zhang X,Sun Y,Lei Q,Sun D,Liu T,Fan Y,Li H,Ding W,Fang J.Yishen capsule promotes podocyte autophagy through regulating SIRT1/NF-κB signaling pathway to improve diabetic nephropathy.Ren Fail.2021 Dec;43(1):128-140.doi:10.1080/08860
Species: Rat
AR1160 usage in article: APP:CELL PROLIFERATION ASSAY, SAMPLE:PODOCYTES, DILUTION:NA
Wenkai Yi,Tao Liu,Xinfeng Gao et al. 4-Hexylresorcinol Inhibits Osteoclastogenesis by Suppressing NF‐κB Signaling Pathway and Reverses Bone Loss in Ovariectomized Mice, 10 November 2020,PREPRINT (Version 1) available at Research Square [+https://doi.org/1
Species: Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:BMMS, DILUTION:NA
Xiaoling Zhang, Liangzhi Du, Ningbo Zhao et al. Effects of bone marrow mesenchymal stem cell-derived exosomes on bone formation on titanium, 05 November 2020, PREPRINT (Version 1) available at Research Square [+https:/ /doi. org/ 10. 2 1203/rs.3.rs-84302/
Species: Rabbit
AR1160 usage in article: APP:CELL PROLIFERATION ASSAY, SAMPLE:RABBIT BONE MARROW MESENCHYMAL STEM CELLS, DILUTION:NA
Yao X,Sun K,Yu S,Luo J,Guo J,Lin J,Wang G,Guo Z,Ye Y,Guo F. Chondrocyte ferroptosis contribute to the progression of osteoarthritis. J Orthop Translat. 2020 Dec 17;27:33-43. doi:10.1016/j.jot. 2020.09.006.PMID:33376672;PMCID:PMC7750492.
Species: Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:CHONDROCYTE, DILUTION:NA
Xubiao Ji,Zhiwen Song,Junsheng He,Shiwu Guo,Yuwei Chen,Honghai Wang,Jinlong Zhang,Xu Xu,Jinbo Liu,NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia/mac rophages and mice models of spinal cord injury, Experimental C
Species: Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:BV-2 CELLS, DILUTION:NA
Wang W,Fang Q,Zhang Z,Wang D,Wu L,Wang Y. PPARα Ameliorates Doxorubicin-Induced Cardiotoxicity by Reducing Mitochondria-Dependent Apoptosis via Regulating MEOX1. Front Pharmacol.2020 Oct 8;11:528267. doi:10.3389/fphar.2020.528267.PMID:33132907;PMCID:PMC75
Species: Human,Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:H9C2 CELL,HEK293T CELL,A549 CELL,MDA-MB-231 CELL AND TC-1 CELL, DILUTION:NA
Qi YL,Li Y,Man XX,Sui HY,Zhao XL,Zhang PX,Qu XS,Zhang H,Wang BX,Li J,Qi SF,Jia LL,Luan HY,Zhang CB,Wang WQ.CXCL3 overexpression promotes the tumorigenic potential of uterine cervical cancer cells via the MAPK/ERK pathway.J Cell Physiol.2020 May;235(5):475
Species: Human,Mouse
AR1160 usage in article: APP:CELL PROLIFERATION ASSAY, SAMPLE:HELA CELL, DILUTION:NA
Wang Y,Liang Y,Li J,Hou R,Li J,Liang N,Xing J,Jiao J,Chang W,Li X,Zhang K.Expression and functional regulation of gap junction protein connexin 43 in dermal mesenchymal stem cells from psoriasis patients.Acta Histochem.2020 May;122(4):151550.doi:10.1016/j
Species: Human
AR1160 usage in article: APP:CELL PROLIFERATION, SAMPLE:DMSCS, DILUTION:NA
Yao X,Yu S,Jing X,Guo J,Sun K,Guo F,Ye Y.PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.Stem Cell
Species: Rat
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:EPCS, DILUTION:NA
Yang S,Wang H,Qin C,Sun H,Han Y.Up-regulation of CXCL8 expression is associated with a poor prognosis and enhances tumor cell malignant behaviors in liver cancer. Biosci Rep.2020 Aug 28;40(8):BSR20201169.doi: 10.1042/BSR20201169.PMID:32766720;PMCID:PMC744
Species: Human
AR1160 usage in article: APP:CELL PROLIFERATION ASSAY, SAMPLE:HEPG 2 CELL, DILUTION:NA
Liu J,Zhang Y,Liu W,Zhang Q,Xiao H,Song H,Luo B.MiR-BART1-5p targets core 2β-1,6-acetylglucosaminyltransferase GCNT3 to inhibit cell proliferation and migration in EBV-associated gastric cancer.Virology.2020 Feb;541:63-74.doi:10.1016/j.virol.2019.12.004.E
Species: AR1160;APP:CELL PROLIFERATION ASSAY;SAMPLE:GT38 CELL,GT39 CELL,SNU719 CELL,AGS CELL,HGC27 CELL,BGC823 CELL AND SGC7901 CELL; DILUTION:NA|AR1016;APP:IHC;SAMPLE:GASTRIC TISSUE;DILUTION:NA
Liao H,Li Y,Zhang X,Zhao X,Zheng D,Shen D,Li R. Protective Effects of Thalidomide on High-Glucose-Induced Podocyte Injury through In Vitro Modulation of Macrophage M1/M2 Differentiation.J Immunol Res.2020 Aug 27;2020:8263598.doi:10.1155/2020/ 8263598.PMID
Species: Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:PODOCYTES AND MACROPHAGES, DILUTION:NA
Li Y,Zheng D,Shen D,Zhang X,Zhao X,Liao H.Protective Effects of Two Safflower Derived Compounds, Kaempferol and Hydroxysafflor Yellow A, on Hyperglycaemic Stress-Induced Podocyte Apoptosis via Modulating of Macrophage M1/M2 Polarization.J Immunol Res.2020
Species: Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:MACROPHAGES, DILUTION:NA
Cheng J, Xu T, Xun C, Guo H, Cao R, Gao S, Sheng W. Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway. Life Sci. 2020 Dec 14;266:118905. doi: 10.1016/j.lfs.2020.118905. Epub ahead of print. PMID
Species: Mouse
AR1160 usage in article: APP:CELL VIABILITY, SAMPLE:PC12 CELLS, DILUTION:NA
Lin G, Wang S, Zhang X, Wang D. Circular RNA circPLK1 promotes breast cancer cell proliferation, migration and invasion by regulating miR-4500/IGF1 axis. Cancer Cell Int. 2020 Dec 9;20(1):593. doi: 10.1186/s12935-020-01694-x. PMID: 33298061; PMCID: PMC772
Species: Human, Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:BT549 CELL AND HCC38 CELL, DILUTION:NA
Fu Y,Zhang Y,Lei Z,Liu T,Cai T,Wang A,Du W,Zeng Y,Zhu J,Liu Z,Huang JA. Abnormally activated OPN/integrin αVβ3/FAK signalling is responsible for EGFR-TKI resistance in EGFR mutant non-small-cell lung cancer. J Hematol Oncol.2020 Dec 7;13(1):169.doi:10.118
Species: Human,Mouse
AR1160 usage in article: APP:CELL VIABILITY, SAMPLE:PC9 CELL,HCC827 CELL AND H1975 CELL, DILUTION:NA
Guo Y, Wu Y, Li N, Wang Z. Up-regulation of miRNA-151-3p enhanced the neuroprotective effect of dexmedetomidine against β-amyloid by targeting DAPK-1 and TP53. Exp Mol Pathol. 2020 Dec 1:104587. doi: 10.1016/ j.yexmp.2020.104587. Epub ahead of print. PMID
Species: Human, Rat
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:SH-SY5Y AND PC12 CELLS, DILUTION:NA
Yi X,Chen W,Li C,Chen X,Lin Q,Lin S,Wang D. Circular RNA circ_0004507 contributes to laryngeal cancer progression and cisplatin resistance by sponging miR-873 to upregulate multidrug resistance 1 and multidrug resistance protein 1. Head Neck.2020 Nov 28.d
Species: Human,Mouse
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:AMC-HN-8 CELL AND TU-177 CELL, DILUTION:NA
Wang J, Bian S, Wang S, Yang S, Zhang W, Zhao D, Liu M, Bai X. Ginsenoside Rh2 represses autophagy to promote cervical cancer cell apoptosis during starvation. Chin Med. 2020 Nov 12;15(1):118. doi:10.1186/ s13020-020-00396-w. PMID: 33292331; PMCID: PMC766
Species: Human
AR1160 usage in article: APP:CELL VIABILITY ASSAY, SAMPLE:HEK293T CELLS, HELA CELLS AND C-33A CELLS, DILUTION:NA
Liu Y, Ju Y, Liu J, Chen Y, Huo X, Liu L. Inhibition of proliferation and migration and induction of apoptosis in glioma cells by silencing TLR4 expression levels via RNA interference. Oncol Lett. 2021 Jan;21(1):13. doi: 10.3892/ol.2020.12274. Epub 2020 N
Species: Human
AR1160 usage in article: APP:CELL VIABILITY, SAMPLE:U‑87MG‑SH, U‑87MG‑NC AND U‑87MG CELLS, DILUTION:NA
Xiao Z, Liang J, Deng Q, Song C, Yang X, Liu Z, Shao Z, Zhang K, Wang X, Li Z. Pimozide augments bromocriptine lethality in prolactinoma cells and in a xenograft model via the STAT5/cyclin D1 and STAT5/Bcl‑xL signaling pathways. Int J Mol Med. 2020 Nov 5.
Species: Human, Rat
AR1160 usage in article: APP:CELL VIABILITY, SAMPLE:MMQ CELLS, DILUTION:NA
Xiao Z, Yang X, Zhang K, Liu Z, Shao Z, Song C, Wang X, Li Z. Estrogen receptor α/prolactin receptor bilateral crosstalk promotes bromocriptine resistance in prolactinomas. Int J Med Sci. 2020 Oct 23;17(18):3174-3189. doi: 10.7150/ijms.51176. PMID: 331734
Species: Human
AR1160 usage in article: APP:CELL VIABILITY ASSAY, DILUTION:NA
Du W, Zhu J, Zeng Y, Liu T, Zhang Y, Cai T, Fu Y, Zhang W, Zhang R, Liu Z, Huang JA. KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway. Cell Death Differ. 2020 Nov 2.
Species: Human
AR1160 usage in article: APP:CELL VIABILITY, SAMPLE:HCC827 and H1299 CELLS, DILUTION:NA
FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway
CPNE1 is a target of miR-335-5p and plays an important role in the pathogenesis of non-small cell lung cancer
Expression of cold-inducible RNA-binding protein (CIRP) in renal cell carcinoma and the effect of CIRP downregulation cell proliferation and chemosensitivity to gemcitabine
Inhibition of autophagy potentiates the proliferation inhibition activity of microRNA-7 in human hepatocellular carcinoma cells
miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-?/Smad4 pathway
MicroRNA-205 targets SMAD4 in non-small cell lung cancer and promotes lung cancer cell growth in vitro and in vivo
CLASP2 is involved in the EMT and early progression after transurethral resection of the bladder tumor
CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer
Three-dimensional Printed Scaffolds with Gelatin and Platelets Enhance In vitro Preosteoblast Growth Behavior and the Sustained-release Effect of Growth Factors
Downregulation of ZEB2-AS1 decreased tumor growth and metastasis in hepatocellular carcinoma
THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer
IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells
Effects of cisplatin on the LSD1-mediated invasion and metastasis of prostate cancer cells
Actein Inhibits Cell Proliferation and Migration in Human Osteosarcoma
Upregulated ATF6 contributes to chronic intermittent hypoxia-afforded protection against myocardial ischemia/reperfusion injury
Downregulation of HIF-1? inhibits the proliferation and invasion of non-small cell lung cancer NCI-H157 cells
SENP?1 enhances hypoxia?induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia?inducible factor?1?
The Mycobacterium bovis BCG prime-Rv0577 DNA boost vaccination induces a durable Th1 immune response in mice
Dose-dependent inhibitory effects of zoledronic acid on osteoblast viability and function in vitro
Downregulation of caveolin-1 upregulates the expression of growth factors and regulators in co-culture of fibroblasts with cancer cells
Demethylation of miR-10b plays a suppressive role in ccRCC cells
Nanog down-regulates the Wnt signaling pathway via ?-catenin phosphorylation during epidermal stem cell proliferation and differentiation
Single peptide ligand-functionalized uniform hollow mesoporous silica nanoparticles achieving dual-targeting drug delivery to tumor cells and angiogenic blood vessel cells
SATB1 Overexpression Regulates the Development and Progression in Bladder Cancer through EMT
Overexpression of Wip1 Is Associated with Biologic Behavior in Human Clear Cell Renal Cell Carcinoma
Clinical implications of AGBL2 expression and its inhibitor latexin in breast cancer
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Liu D, Zhang XX, Li MC, Cao CH, Wan DY, Xi BX, Tan JH, Wang J, Yang ZY, Feng XX, Ye F, Chen G, Wu P, Xi L, Wang H, Zhou JF, Feng ZH, Ma D, Gao QL. Nat Commun. 2018 Apr 30;9(1):1739. doi: 10.1038/s41467-018-03590-5. C/EBPβ enhances platinum resista...
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Fang X, Han Q, Li S, Zhao Y, Luo A. Am J Transl Res. 2017 Sep 15;9(9):4288-4299. eCollection 2017. Chikusetsu saponin IVa attenuates isoflurane-induced neurotoxicity and cognitive deficits via SIRT1/ERK1/2 in developmental rats
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Lai J, Chen F, Chen J, Ruan G, He M, Chen C, Tang J, Wang DW. Sci Rep. 2017 Mar 14;7:44473. doi: 10.1038/srep44473. Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling
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Guo J, Li W, Wu Y, Jing X, Huang J, Zhang J, Xiang W, Ren R, Lv Z, Xiao J, Guo F. Front Pharmacol. 2017 Oct 4;8:693. doi: 10.3389/fphar.2017.00693. eCollection 2017. Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis ...
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Zhu Y, Lu H, Zhang D, Li M, Sun X, Wan L, Yu D, Tian Y, Jin H, Lin A, Gao F, Lai M. Clin Epigenetics. 2018 Mar 2;10:30. doi: 10.1186/s13148-018-0458-3. eCollection 2018. Integrated analyses of multi-omics reveal global patterns of methylation and ...
Huang, X., Pan, Q., Mao, Z., Zhang, R., Ma, X., Xi, Y., & You, H. (2017). Sinapic Acid Inhibits the IL-1β-Induced Inflammation via MAPK Downregulation in Rat Chondrocytes. Inflammation, 1-7. Advance online publication. doi: 10.1007/s10753-017-0712-4
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Lan, T., Yan, X., Li, Z., Xu, X., Mao, Q., Ma, W.,…, & Yuan, Y. (2017). Long non-coding RNA PVT1 serves as a competing endogenous RNA for miR-186-5p to promote the tumorigenesis and metastasis of hepatocellular carcinoma. Tumor Biology, 39(6), 1-1...
Liu, L., Li, H., Cui, Y., Li, R., Meng, F., Ye, Z., & Zhang, X. (2017). Calcium Channel Opening Rather than the Release of ATP Causes the Apoptosis of Osteoblasts Induced by Overloaded Mechanical Stimulation. Cellular Physiology and Biochemistry, ...
Li R, Wu X, Wei H, Tian S. Oncol Lett. 2013 Mar;5(3):877-883. Epub 2013 Jan 2. Characterization Of Side Population Cells Isolated From The Gastric Cancer Cell Line Sgc-7901.
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Ma Yj, He M, Han Ja, Yang L, Ji Xy. Scand J Immunol. 2013 Oct;78(4):387-93. Doi: 10.1111/Sji.12097. A Clinical Study Of Hbsag-Activated Dendritic Cells And Cytokine-Induced Killer Cells During The Treatment For Chronic Hepatitis B.
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Li Q, Wang Z. Arch Med Res. 2013 Oct;44(7):504-13. Doi: 10.1016/J.Arcmed.2013.09.009. Epub 2013 Oct 10. Influence Of Mesenchymal Stem Cells With Endothelial Progenitor Cells In Co-Culture On Osteogenesis And Angiogenesis: An In Vitro Study.
Zhang D, Tian A, Xue X, Wang M, Qiu B, Wu A. Int J Mol Sci. 2012;13(1):1109-25. Doi: 10.3390/Ijms13011109. Epub 2012 Jan 19. The Effect Of Temozolomide/Poly(Lactide-Co-Glycolide) (Plga)/Nano-Hydroxyapatite Microspheres On Glioma U87 Cells Behavior.
Zhang J, Xiao Z, Lai D, Sun J, He C, Chu Z, Ye H, Chen S, Wang J. Br J Cancer. 2012 Jul 10;107(2):352-9. Doi: 10.1038/Bjc.2012.251. Epub 2012 Jun 7. Mir-21, Mir-17 And Mir-19A Induced By Phosphatase Of Regenerating Liver-3 Promote The Proliferatio...
Qin X, Yan L, Zhao X, Li C, Fu Y. Oncol Lett. 2012 Dec;4(6):1290-1296. Epub 2012 Sep 6. Microrna-21 Overexpression Contributes To Cell Proliferation By Targeting Pten In Endometrioid Endometrial Cancer.
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Chiou Hy, Liu Sy, Lin Ch, Lee Eh. J Biomed Sci. 2014 Jun 4;21:53. Doi: 10.1186/1423-0127-21-53. Hes-1 Sumoylation By Protein Inhibitor Of Activated Stat1 Enhances The Suppressing Effect Of Hes-1 On Gadd45?? Expression To Increase Cell Survival.
Ke S, Zhou F, Yang H, Wei Y, Gong J, Mei Z, Wu L, Yu H, Zhou Y. Int J Oncol. 2015 Mar;46(3):1051-8. Doi: 10.3892/Ijo.2014.2793. Epub 2014 Dec 10. Downregulation Of High Mobility Group Box 1 Modulates Telomere Homeostasis And Increases The Radiosen...
Zhu H, Yun F, Shi X, Wang D. Mol Med Rep. 2015 Aug;12(2):3163-9. Doi: 10.3892/Mmr.2015.3684. Epub 2015 Apr 24. Vegf-C Inhibition Reverses Resistance Of Bladder Cancer Cells To Cisplatin Via Upregulating Maspin.
Zhu H, Yun F, Shi X, Wang D. Int J Mol Med. 2015 Aug;36(2):595-601. Doi: 10.3892/Ijmm.2015.2250. Epub 2015 Jun 17. Inhibition Of Igfbp-2 Improves The Sensitivity Of Bladder Cancer Cells To Cisplatin Via Upregulating The Expression Of Maspin.
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Customer Q&As
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2 Customer Q&As for Cell Counting Kit-8 (CCK-8)
Question
Does AR1160 contain the thimerosal or the sodium azide (or other toxic substances)? If so, what is the concentration?
Verified customer
Asked: 2019-05-23
Answer
The Cell Counting Kit-8 (CCK-8) (AR1160) does not contain thimerosal, sodium azide, or other toxic substances.
Boster Scientific Support
Answered: 2019-05-23
Question
Does AR1160 contain recombinant protein produced with baculovirus?
Verified customer
Asked: 2019-05-23
Answer
The Cell Counting Kit-8 (CCK-8) (AR1160) doesn't contain recombinant protein produced with baculovirus.
Boster Scientific Support
Answered: 2019-05-29
