DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) for nucleic acid staining

DAPI Stain Solution, IHC Related Reagent, For nucleus restaining in Immunofluorescence experiments Cited in 95 publication(s).

Product Info Summary

Catalog numberUnit SizePrice (USD)
AR1176-1010mL (100 assays)15
AR1176-5050mL (500 assays)35

Product Overview

Product Name DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) for nucleic acid staining
Material DAPI dihydrochloride (MW = 350.3)
Form Liquid
Size 10 mL (100 assays)/50 mL (500 assays)
Concentration 1μg/ml
Buffer 8 mM sodium phosphate, 2 mM potassium phosphate, 140 mM sodium chloride, 10 mM potassium chloride; pH 7.4.
Storage Upon receipt store at -20°C, protect from light.
Stability When stored as directed, product should be stable for one year.
Molecular formula C16H15N5 • 2 HCL
Excitation: DAPI 340nm
Emission: DAPI 488nm
Excitation: DAPI-DNA complexes 360nm
Emission: DAPI-DNA complexes 460nm
Equivalent Thermofisher (Product No. 62247); Thermofisher (Product No. 62248); Millipore Sigma (Product No. D9542)

Notes

Type of DAPIMolecular formulaMolecular weightCatalog Number
DAPI dihydrochlorideC16H15N5 • 2 HCL350.25AR1176-10
DAPI dilactateC16H15N5 • 2 C3H6O3457.48N/A

Introduction

DAPI (4',6-diamidino-2-phenylindole) is a fluorescent dye which can bind DNA strands robustly, the fluorescence being detected by fluorescence microscope. DAPI can dye both live and fixed cells as it can cross intact membrane, with higher efficiency in fixed cells. The molecular formula is C16H15N5•2HCl with 350.25 g/mol molecular weight, CAS Number 28718-90-3. DAPI could pass through the cell and nucleic membranes and bind the double-strand DNA in the nucleus, producing 20 times stronger fluorescence than itself. The efficiency detected by fluorescence microscope is very high (almost 100%), having no side effects for the live cells. The sensitivity for double stranded DNA DAPI staining is many times larger comparing to ethidium bromide (EB). DAPI staining is usually used in cell death detection, as it enters more effectively and generates stronger fluorescence in dead cells. After staining with DAPI, detect with fluorescence microscope or flow cytometry. Blue fluorescent cell would be seen under the microscope after staining. The largest excitation wavelength for DAPI is 340nm (ultraviolet), and the largest emission wavelength is 488nm (blue). When DAPI binds with double-strand DNA, the largest excitation wavelength is 360nm, while the largest emission wavelength becomes 460nm. DAPI's blue emission makes it suitable for combined assays where the fluorescence ranges of DAPI and other IHC-employed fluorescent molecules like green-fluorescent fluorescein and GFP, or red-fluorescent stains like Texas Red, are completely distinctive.

Properties

Enzymatic Activity DNase-, RNase-, Protease- free
Cell Permeability Intact membrane permeant
Sub-Cellular Localization: Nucleus
Biomolecule Reactivity Specific binding to AT-base pairs; intercalation into GC-base pairs;
Cite This Product DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) for nucleic acid staining (Boster Biological Technology, Pleasanton CA, USA, Catalog # AR1176)

Application

Fluorescent bioimaging; Immunofluorescence assays, flow cytometry; in situ hybridization; hystology; IHC; HCS; quantification of DNA content; labeling of DNA in cell cultures; cell death detection

Usage and Handling

    For DNA and chromosomes staining, In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
    DAPI is a known mutagen and should be handled with care.

Protocol

1. Fixed cells and tissues: wash appropriately to remove fixative. If necessary, immunofluorescent staining can be performed first, then perform the DAPI staining. If there is no other staining, perform DAPI staining directly.
Adherent cells or tissue slices: add a sufficient volume of DAPI stain solution to completely cover the sample.
Suspension cells: Add DAPI stain solution to suspend cell pellets at 3:1. Vortex to obtain an even suspension.

2. Incubate for 5-10 minutes at RT (room temperature).

3. Remove the stain solution.

4. Wash with TBST, PBS or physiological saline for 2-3 times, 3-5 minutes each.

5. Observe the sample under fluorescence microscope (excitation wavelength: 360nm, emission wavelength:460nm).


Notes:

1. Use Boster Antifade Mounting Medium (Product No. AR1109) to prevent rapid photobleaching of fluorescence within spectrum range.

2. Please wear the lab coat and disposable gloves to operate.

Chemical Information

Chemical Name 4′,6-Diamidino-2-phenylindole dihydrochloride
IUPAC Name 2- (4-Amidinophenyl)-1H-indole-6-carboxamidine dihidrochloride
Molecular Formula C16H15N5·2HCl; C16H17Cl2N5
Molecular Weight 350.25
CAS 28718-90-3
EC Number 249-186-7
Chemical Sources ChEMBL: CHEMBL48217; CHEMBL531243; SCHEMBL2464378; CHEMBL545547
CHEBI: CHEBI:51231
ChemSpider: 2848; 123458; 140783
PubChem: 2954; 21924871; 67094309; 160166

Product Images

AR1176 has been cited in 95 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Blood-brain barrier dysfunction induced by silica NPs in vitro and in vivo: Involvement of oxidative stress and Rho-kinase/JNK signaling pathways

Synergized Multimodal Therapy for Safe and Effective Reversal of Cancer Multidrug Resistance Based on Low‐Level Photothermal and Photodynamic Effects

Artificial Nanotargeted Cells with Stable Photothermal Performance for Multimodal Imaging-Guided Tumor-Specific Therapy

Flexible Electronics and Materials for Synchronized Stimulation and Monitoring in Multi‐Encephalic Regions

Yao X,Jing X,Guo J,Sun K,Deng Y,Zhang Y,Guo F,Ye Y.Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.Front Pharmacol.2019 Feb 28;10:163. doi:10.3389/fphar.2019.00163.PMID:30873034;PMCID:PMC6403125.
Species: Rat
AR1176 usage in article: APP:IF, SAMPLE:BMSCS, DILUTION:NA

Yiping Lin,Jingchan Yao,Meiling Wu,Xiaoqian Ying,Mingxing Ding,Yanli Wei,Xiaoyan Fu,Wei Feng,Yunguang Wang,"Tetrandrine Ameliorates Airway Remodeling of Chronic Asthma by Interfering TGF-β1/Nrf-2/HO-1 Signaling Pathway-Mediated Oxidative Stress",Canadian Respiratory Journal,vol.2019,Article ID 7930396,12 pages,2019.https://doi.org/10.1155/2019/7930396
Species: Rat
AR1176 usage in article: APP:IF, SAMPLE:ASMCS, DILUTION: NA

Nina Yin,Man Long,Zhigang Wang et al.Electroacupuncture Pretreatment Attenuates Cerebral Ischemia-Reperfusion Injury through Transient Receptor Potential Vanilloid 1-Mediated Anti-Apoptosis via Inhibiting NF-kB Signaling Pathway,30 June 2021,PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-657177/v1]
Species: Rat
AR1176 usage in article: APP:IF, SAMPLE:BRAIN TISSUE, DILUTION:NA

Chen,X.,Liu,C.,Zhang,M.et al.Maduramicin arrests myocardial cells at G0/G1 phase of the cell cycle through inhibiting AKT-Cyclin D1 signaling.3 Biotech 11,347(2021).https://doi.org/10.1007/s13205-021-02894-6
Species: Rat
AR1176 usage in article: APP:BRDU LABELING, SAMPLE:H9C2 CELL, DILUTION:NA

Yiqiang Hu,Bin Wu,Yuan Xiong,Ranyang Tao,Adriana C.Panayi,Lang Chen,Wenqing Tian,Hang Xue,Lei Shi,Xianglin Zhang,Liming Xiong,Bobin Mi,Guohui Liu,Cryogenic 3D Printed Hydrogel Scaffolds Loading Exosomes Accelerate Diabetic Wound Healing,Chemical Engineering Journal,2021,130634,ISSN 1385-8947,https://doi.org/10.1016/j.cej.2021.130634.
Species: Human,Rat
AR1176 usage in article: APP:IF, SAMPLE:SKIN TISSUE, DILUTION:NA

Ren Y,Jiang J,Jiang W,Zhou X,Lu W,Wang J,Luo Y.Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats.Neurochem Res.2021 Jun 1.doi:10.1007/s11064-021-03360-8.Epub ahead of print.PMID:34075523.
Species: Rat
AR1176 usage in article: APP: IF, SAMPLE:BRAIN TISSUE, DILUTION:NA

Huang C,Wang D,Li N,Yang C,Chen X,Liu X,He J,Ding Y,Tong C,Peng C,Li F,Wang Y,Gao R.Exposure to ethephon compromises endometrial decidualization in mice during early pregnancy via GPR120.Ecotoxicol Environ Saf.2021 May 27;220:112361.doi:10.1016/j.ecoenv.2021.112361.Epub ahead of print.PMID:34052757.
Species: Mouse
AR1176 usage in article: APP:IF, SAMPLE:MESCS, DILUTION:NA

Yinyan Xu,Hengli Guo,Tingting Zhao,Jing Fu,Youhua Xu,"Mulberroside A from Cortex Mori Enhanced Gut Integrity in Diabetes",Evidence-Based Complementary and Alternative Medicine,vol.2021,Article ID 6655555,11 pages,2021.https://doi.org/10.1155/2021/6655555
Species: Human,Mouse
AR1176 usage in article: APP:IF, SAMPLE:CACO-2 CELL, DILUTION:NA

Xiao X,Bu H,Li Z,Li Z,Bai Q,Wang Z,Yan L,Liu D,Peng X,Jia X,Gao F.NADPH-Oxidase 2 Promotes Autophagy in Spinal Neurons During the Development of Morphine Tolerance.Neurochem Res.2021 May 18.doi:10.1007/s11064-021-03347-5.Epub ahead of print.PMID:34008119.
Species: Rat
AR1176 usage in article: APP:DOUBLE IF, SAMPLE:SPINAL CORD TISSUE, DILUTION:NA

Peng Xu,Min Xing,Huizhen Huang,Ke Xue,Jiang Chang,Kai Liu,Calcium Silicate-human Serum Albumin Composite Hydrogel Decreases Random Pattern Skin Flap Necrosis by Attenuating Vascular Endothelial Cell Apoptosis and Inflammation,Chemical Engineering Journal,2021,130285,ISSN 1385-8947,https://doi.org/10.1016/j.cej.2021.130285.
Species: Rat
AR1176 usage in article: APP:TUNNEL STAINING, SAMPLE:SKIN FLAP, DILUTION:1:1000

Yin Z,Hua L,Chen L,Hu D,Li J,An Z,Tian T,Ning H,Ge Y.Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells.Toxicol In Vitro.2020 Sep;67:104911.doi:10.1016/j.tiv.2020.104911.Epub 2020 Jun 5.PMID:32512148.
Species: Mouse
AR1176 usage in article: APP:IF, SAMPLE:NEURO-2A CELL, DILUTION:NA

Chen Y,Sun T,Niu Y,Wang D,Liu K,Wang T,Wang S,Xu H,Liu J.A partial loss-of-function variant in GNRNR gene in a Chinese cohort with idiopathic hypogonadotropic hypogonadism.Transl Androl Urol.2021 Apr;10(4):1676-1687.doi:10.21037/tau-20-1390.PMID:33968656;PMCID:PMC8100836.
Species: Human,African Green Monkey
AR1176 usage in article: APP:IF, SAMPLE:COS-7 CELL, DILUTION:NA

Ma Y,Chen SS,Jiang F,Ma RY,Wang HL.Bioinformatic analysis and validation of microRNA-508-3p as a protective predictor by targeting NR4A3/MEK axis in pulmonary arterial hypertension.J Cell Mol Med.2021 May 4.doi:10.1111/jcmm.16523.Epub ahead of print.PMID:33942991.
Species: Human,Rat
AR1176 usage in article: APP:ICC, SAMPLE:PASMC, DILUTION:NA

Songxue Guo,Meirong Yu,Quan Fang,Liping Zhang,Chuangang You,Xingang Wang,Yong Liu,Chunmao Han,Heme oxygenase-1 induction mitigates burn-associated early acute kidney injury via the TLR4 signaling pathway,Burns,2021,,ISSN 0305-4179,https://doi.org/10.1016/j.burns.2021.04.013.
Species: Rat
AR1176 usage in article: APP:IF, SAMPLE:RENAL TISSUE, DILUTION:NA

Zhang L,Zhang J,Gong Y,Lv L.Systematic and experimental investigations of the anti-colorectal cancer mediated by genistein. Biofactors.2020 Nov;46(6):974-982.doi:10.1002/biof.1677.Epub 2020 Sep 20.PMID:32951326.
Species: Human,Mouse
AR1176 usage in article: APP:IF, SAMPLE:CRC TISSUE, DILUTION:NA

Yin SL,Xiao F,Liu YF,Chen H,Guo GC.Long non-coding RNA FENDRR restrains the aggressiveness of CRC via regulating miR-18a-5p/ING4 axis.J Cell Biochem.2019 Nov 13.doi:10.1002/jcb.29555.Epub ahead of print.PMID:31724220.
Species: Human,Mouse
AR1176 usage in article: APP:IF, SAMPLE:CRC CELLS, DILUTION:NA

Zhao, S., Li, C., Gao, Y. et al. Screening and Identification of a Specific Binding Peptide to Ovarian Cancer Cells from a Phage-Displayed Peptide Library. Int J Pept Res Ther (2021). https://doi.org/10.1007/s10989-021-10206-y
Species: Human
AR1176 usage in article: APP:IF, SAMPLE:SKOV3 CELL,HELA CELL,AN3CA CELL, MCF7 CELL,MHCC97-H CELL AND HEK293 CELL, DILUTION:NA

Guo S,Guo L,Fang Q,Yu M,Zhang L,You C,Wang X,Liu Y,Han C.Astaxanthin protects against early acute kidney injury in severely burned rats by inactivating the TLR4/MyD88/NF-κB axis and upregulating heme oxygenase-1.Sci Rep.2021 Mar 23;11 (1):6679.doi:10.1038/s41598-021-86146-w.PMID:33758309;PMCID:PMC7988001.
Species: Rat
AR1176 usage in article: APP:IF, SAMPLE:KIDNEY TISSUE, DILUTION:NA

Zhou H, Fang Q, Li N, Yu M, Chen H, Guo S. ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑ associated apoptosis via the Erk/p90RSK/Bad pathway. Mol Med Rep. 2021 May;23(5):390. doi: 10.3892/mmr.2021.12029. Epub 2021 Mar 24. PMID: 33760179.
Species: Rat
AR1176 usage in article: APP:IF, SAMPLE:SKIN TISSUE, DILUTION:NA

Lv X,Gao F,Zhang S,Zhang S,Zhou X,Ding F,Wang J,Chen Q,Chen M,Liu Q.Maladjustment of β-CGRP/α-CGRP Regulation of AQP5 Promotes Transition of Alveolar Epithelial Cell Apoptosis to Pulmonary Fibrosis.J Interferon Cytokine Res.2020 Aug;40(8):377-388.doi:10.1
Species: Human,Mouse
AR1176 usage in article: APP:IF, SAMPLE:LUNG SECTION, DILUTION:NA

Ma Y,Yang L,Li R.HnRNPA2/B1 Is a Novel Prognostic Biomarker for Breast Cancer Patients.Genet Test Mol Biomarkers.2020 Nov;24(11):701-707.doi:10.1089/gtmb.2020.0086.Epub 2020 Sep 25.PMID:32985904.
Species: Human
AR1176 usage in article: APP:IF, SAMPLE:BREAST TISSUE, DILUTION:NA

Xu J, Zhang Y, Ren G, Yang R, Chen J, Xiang X, Qin H, Chen J. Inhibitory Effect of Delphinidin on Oxidative Stress Induced by H2O2 in HepG2 Cells. Oxid Med Cell Longev. 2020 Nov 20;2020:4694760. doi: 10.1155/2020/4694760. PMID: 33274001; PMCID: PMC7700032
Species: Human
AR1176 usage in article: APP:IF, SAMPLE:HEPG2 CELLS, DILUTION:NA

Li J, Shang Y, Wang L, Zhao B, Sun C, Li J, Liu S, Li C, Tang M, Meng FL, Zheng P. Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia. Sci Adv. 2020 Oct 28;6(44):eaba0682. doi: 10.1126/
Species: Mouse
AR1176 usage in article: APP:IHC, SAMPLE:BRAIN, DILUTION:NA

In vitro model of the glial scar Ao Fang,1,2 Zhiyan Hao,1,2 Ling Wang,1,2 Dichen Li,1,2,* Jiankang He,1,2 Lin Gao,1,2 Xinggang Mao,3 and Rubén Paz4 Int J Bioprint. 2019; 5(2): 235. Published online 2019 Jul 30. doi: 10.18063/ijb.v5i2.235

miRNA-101-5p inhibits the growth and aggressiveness of NSCLC cells through targeting CXCL6 Qi Chen,1,2 Dan Liu,3 Zhi Hu,4 Cheng Luo,1 and Si Lin Zheng2 Onco Targets Ther. 2019; 12: 835–848. Published online 2019 Jan 25. doi: 10.2147/OTT.S184235

Hypoxia promotes maintenance of the chondrogenic phenotype in rat growth plate chondrocytes through the HIF-1%u03B1/YAP signaling pathway

Protective Role of L-3-n-Butylphthalide in Cognitive Function and Dysthymic Disorders in Mouse With Chronic Epilepsy

Tanshinone IIA promotes the differentiation of bone marrow mesenchymal stem cells into neuronal-like cells in a spinal cord injury model

Cdk5 Inhibitory Peptide Prevents Loss of Dopaminergic Neurons and Alleviates Behavioral Changes in an MPTP Induced Parkinson?s Disease Mouse Model

ARL2 overexpression inhibits glioma proliferation and tumorigenicity via down-regulating AXL

Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-?B signaling in an IL-6-dependent manner

Maternal high-fat diet impairs glucose metabolism, ?-cell function and proliferation in the second generation of offspring rats

SnoN upregulation ameliorates renal fibrosis in diabetic nephropathy

Twist1 Enhances Hypoxia Induced Radioresistance in Cervical Cancer Cells by Promoting Nuclear EGFR Localization

Knockdown of ELMO3 Suppresses Growth, Invasion and Metastasis of Colorectal Cancer

Estrogen-induced SDF-1? production promotes the progression of ER-negative breast cancer via the accumulation of MDSCs in the tumor microenvironment

Telocytes: a potential defender in the spleen of Npc1 mutant mice

Nur77 attenuates endothelin-1 expression via downregulation of NF-?B and p38 MAPK in A549 cells and in an ARDS rat model

Differences in Proinflammatory Property of Six Subtypes of Peroxiredoxins and Anti-Inflammatory Effect of Ligustilide in Macrophages

Effects of Berberine on NLRP3 and IL-1??Expressions in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation

TGF-?/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease

Oxymatrine Inhibits Renal Tubular EMT Induced by High Glucose via Upregulation of SnoN and Inhibition of TGF-?1/Smad Signaling Pathway

Silver nanoparticles/chitosan oligosaccharide/poly(vinyl alcohol) nanofiber promotes wound healing by activating TGF?1/Smad signaling pathway

Chronic sciatic nerve compression induces fibrosis in dorsal root ganglia

Regulation of the osteogenic and adipogenic differentiation of bone marrow-derived stromal cells by extracellular uridine triphosphate: The role of P2Y2 receptor and ERK1/2 signaling

Isolation and characteristics of CD133?/A2B5+ and CD133?/A2B5? cells from the SHG139s cell line

Integrin-?1, not integrin-?5, mediates osteoblastic differentiation and ECM formation promoted by mechanical tensile strain

Cancer-Associated Fibroblasts in a Human HEp-2 Established Laryngeal Xenografted Tumor Are Not Derived from Cancer Cells through Epithelial-Mesenchymal Transition, Phenotypically Activated but Karyotypically Normal

Paxillin regulates vascular endothelial growth factor A-induced?in vitro?angiogenesis of human umbilical vein endothelial cells

A potential therapeutic effect of CYP2C8 overexpression on anti-TNF-? activity

Engineered ubiquitin ligase PTB-U-box targets insulin/insulin-like growth factor receptor for degradation and coordinately inhibits cancer malignancy

Novel Antibody against a Glutamic Acid-Rich Human Fibrinogen-Like Protein 2-Derived Peptide near Ser91 Inhibits hfgl2 Prothrombinase Activity

Positive Feedback-Loop of Telomerase Reverse Transcriptase and 15-Lipoxygenase-2 Promotes Pulmonary Hypertension

Histone acetyltransferase PCAF Up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling

Identification of Cancer Stem-Like Side Population Cells in Purified Primary Cultured Human Laryngeal Squamous Cell Carcinoma Epithelia

Generation of induced pluripotent stem cells from human Tenon?s capsule fibroblasts

Characterization and retinal neuron differentiation of WERI-Rb1 cancer stem cells

Efficient Commitment to Functional CD34+ Progenitor Cells from Human Bone Marrow Mesenchymal Stem-Cell-Derived Induced Pluripotent Stem Cells

Mucins Differently Expressed in Various Ampullary Adenocarcinomas

Yu X, Zhang F, Mao J, Lu Y, Li J, Ma W, Fan S, Zhang C, Li Q, Wang B, Song B, Li L. Oncotarget. 2017 Oct 24;8(58):98798-98811. doi: 10.18632/oncotarget.22000. eCollection 2017 Nov 17. Protein tyrosine phosphatase receptor-type δ acts as a negative...

Sun AJ, Qiao L, Huang C, Zhang X, Li YQ, Yang XQ. Mol Med Rep. 2018 May;17(5):7055-7064. doi: 10.3892/mmr.2018.8792. Epub 2018 Mar 20. Comparison of mouse brown and white adipose-derived stem cell differentiation into pacemaker-like cells induced ...

Li R, Ou J, Li L, Yang Y, Zhao J, Wu R. Front Pharmacol. 2018 Apr 16;9:379. doi: 10.3389/fphar.2018.00379. eCollection 2018. The Wnt Signaling Pathway Effector TCF7L2 Mediates Olanzapine-Induced Weight Gain and Insulin Resistance

Kong L, Qiu L, Guo Q, Chen Y, Zhang X, Chen B, Zhang Y, Chang G. PLoS One. 2018 Apr 30;13(4):e0196459. doi: 10.1371/journal.pone.0196459. eCollection 2018. Long-term in vitro culture and preliminary establishment of chicken primordial germ cell lines

Liu TT, Li Y, Shu Y, Xiao B, Feng L. Int J Mol Med. 2018 Jun;41(6):3457-3467. doi: 10.3892/ijmm.2018.3543. Epub 2018 Mar 7. Ephrin-B3 modulates hippocampal neurogenesis and the reelin signaling pathway in a pilocarpine-induced model of epilepsy

Yan Q1, Li Y1, Yan J2, Zhao Y3, Liu Y3, Liu S3. Exp Ther Med. 2018 Feb;15(2):1433-1441. doi: 10.3892/etm.2017.5514. Epub 2017 Nov 16. Effects of luteolin on regulatory proteins and enzymes for myocyte calcium circulation in hypothermic preserved r...

Li B, Xu L, Tao F, Xie K, Wu Z, Li Y, Li J, Chen K, Pi C, Mendelsohn A, Larrick JW, Gu H, Fang J. Oncotarget. 2017 Jun 13;8(24):39356-39366. doi: 10.18632/oncotarget.17000. Simultaneous exposure to FcγR and FcαR on monocytes and macrophages enhanc...

Wu F, Chen J, Fan LM, Liu K, Zhang N, Li SW, Zhu H, Gao HC. Exp Ther Med. 2017 Jul;14(1):127-130. doi: 10.3892/etm.2017.4494. Epub 2017 May 22. Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer

Ma WT, Jia YJ, Liu QZ, Yang YQ, Yang JB, Zhao ZB, Yang ZY, Shi QH, Ma HD, Gershwin ME, Lian ZX. Cell Death Dis. 2017 May 25;8(5):e2827. doi: 10.1038/cddis.2017.47. Modulation of liver regeneration via myeloid PTEN deficiency

Ling L, Feng X, Wei T, Wang Y, Wang Y, Zhang W, He L, Wang Z, Zeng Q, Xiong Z. Stem Cell Res Ther. 2017 Dec 19;8(1):283. doi: 10.1186/s13287-017-0739-3. Effects of low-intensity pulsed ultrasound (LIPUS)-pretreated human amnion-derived mesenchymal...

Chen Q, Wu H, Tao J, Liu C, Deng Z, Liu Y, Chen G, Liu B, Xu C. PLoS One. 2017 Aug 23;12(8):e0183688. doi: 10.1371/journal.pone.0183688. eCollection 2017. Effect of naringin on gp120-induced injury mediated by P2X7 receptors in rat primary culture...

Tang S, Pan H, Wei W, Yang H, Liu J, Yang R. Oncotarget. 2017 Oct 19;8(62):105155-105169. doi: 10.18632/oncotarget.21927. eCollection 2017 Dec 1. GOLPH3: a novel biomarker that correlates with poor survival and resistance to chemotherapy in breast...

Mao XN, Zhou HJ, Yang XJ, Zhao LX, Kuang X, Chen C, Liu DL, Du JR. Oncotarget. 2017 Jun 28;8(53):90979-90995. doi: 10.18632/oncotarget.18773. eCollection 2017 Oct 31. Neuroprotective effect of a novel gastrodin derivative against ischemic brain in...

Huang JM, Bao Y, Xiang W, Jing XZ, Guo JC, Yao XD, Wang R, Guo FJ. Evid Based Complement Alternat Med. 2017;2017:8085325. doi: 10.1155/2017/8085325. Epub 2017 Dec 27. Icariin Regulates the Bidirectional Differentiation of Bone Marrow Mesenchymal S...

Guo J, Li W, Wu Y, Jing X, Huang J, Zhang J, Xiang W, Ren R, Lv Z, Xiao J, Guo F. Front Pharmacol. 2017 Oct 4;8:693. doi: 10.3389/fphar.2017.00693. eCollection 2017. Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis ...

Zhang J, Peng X, Yuan A, Xie Y, Yang Q, Xue L. Mol Med Rep. 2017 Sep;16(3):2636-2644. doi: 10.3892/mmr.2017.6903. Epub 2017 Jun 30. Peroxisome proliferator-activated receptor γ mediates porcine placental angiogenesis through hypoxia inducible fact...

Liu H, Lv P, Zhu Y, Wu H, Zhang K, Xu F, Zheng L, Zhao J. Sci Rep. 2017 Jan 5;7:39869. doi: 10.1038/srep39869. Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo

Liu CL, Deng ZY, Du ER, Xu CS. Mol Med Rep. 2018 Apr;17(4):5851-5859. doi: 10.3892/mmr.2018.8601. Epub 2018 Feb 13. Long non-coding RNA BC168687 small interfering RNA reduces high glucose and high free fatty acid-induced expression of P2X7 recepto...

Zhou, X., Zhang, Y., Li, Y., Xu, Y., Zhang, L., Li, Y., & Wang, X. (2017). Klotho suppresses tumor progression via inhibiting IGF-1R signaling in T-cell lymphoma. Oncology Reports, 38(2), 967-974. Advance online publication. doi: 10.3892/or.2017.5744

Liu, Y., Jiang, Y., Wang, N., Jin, Q., Ji, F., Zhong, C.,…, & Chen, T. (2017). Invalidation of mitophagy by FBP1-mediated repression promotes apoptosis in breast cancer. Tumor Biology, 39(6), 1-13. doi: 10.1177/1010428317708779

Xie, Z., Chen, J., Zheng, C., Wu, J., Cheng, Y., Zhu, S.,…, & Jin, T. (2017). 1,25-dihydroxyvitamin D3 induced dendritic cells suppress experimental autoimmune encephalomyelitis by increasing proportions of the regulatory lymphocytes and reducing ...

Baisong Zhao, Yongying Pan, Zixin Wang, Haiping Xu and Xingrong Song. Yonsei Med J. 2017 Jan;58(1):131-138. Hyperbaric Oxygen Pretreatment Improves Cognition and Reduces Hippocampal Damage Via p38 Mitogen-Activated Protein Kinase in a Rat Model

Li D, Wei X, Xie K, Chen K, Li J, Fang J. Br J Cancer. 2014 Jul 8;111(1):68-77. Doi: 10.1038/Bjc.2014.282. Epub 2014 May 29. A Novel Decoy Receptor Fusion Protein For Fgf-2 Potently Inhibits Tumour Growth.

Gai X, Lu Z, Tu K, Liang Z, Zheng X. Plos One. 2014 Jan 13;9(1):E84551. Doi: 10.1371/Journal.Pone.0084551. Ecollection 2014. Caveolin-1 Is Up-Regulated By Gli1 And Contributes To Gli1-Driven Emt In Hepatocellular Carcinoma.

Zhu B, Xu T, Yuan J, Guo X, Liu D. Plos One. 2013 Sep 19;8(9):E76282. Doi: 10.1371/Journal.Pone.0076282. Ecollection 2013. Transcriptome Sequencing Reveals Differences Between Primary And Secondary Hair Follicle-Derived Dermal Papilla Cells Of The...

Cheng C, Wan F, Liu L, Zeng F, Xing S, Wu X, Chen X, Zhu Z. Plos One. 2014 May 16;9(5):E97406. Doi: 10.1371/Journal.Pone.0097406. Ecollection 2014. Overexpression Of Satb1 Is Associated With Biologic Behavior In Human Renal Cell Carcinoma.

Wang F, Zhou H, Yang Y, Xia X, Sun Q, Luo J, Cheng B. Oncol Rep. 2012 Apr;27(4):1170-6. Doi: 10.3892/Or.2012.1620. Epub 2012 Jan 3. Hepatitis B Virus X Protein Promotes The Growth Of Hepatocellular Carcinoma By Modulation Of The Notch ...

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