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Product Info Summary
| SKU: | A00798 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Activin receptor type-1 ACVR1 Antibody
SKU/Catalog Number
A00798
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Activin receptor type-1 ACVR1 Antibody (Catalog # A00798). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
ACVR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Activin receptor type-1 ACVR1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00798)
Host
Rabbit
Contents
ACVR1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
ACVR1 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of the human ACVR1. The immunogen is located within the first 50 amino acids of ACVR1.
Cross-reactivity
At least four isoforms of ACVR1 are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1B or ACVR1C.
Reactive Species
A00798 is reactive to ACVR1 in Human, Mouse
Observed Molecular Weight
68 kDa
Calculated molecular weight
57.2 kDa
Background of ACVR1
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. Unlike ACVR1B and ACVR1C, ACVR1, also known as activin receptor-like kinase 2 (ALK2), can not transduce activin-mediated signaling, but will transduce BMP and Mullerian inhibiting substance (MIS) group signaling. It is thought that ACVR1 also inhibits activin signaling by blocking the binding of activin to its type II receptor. Recent studies indicate that genetic variation in ACVR1 is associated with polycystic ovary syndrome, suggesting that ACVR1 signaling contributes to disturbed folliculogenesis in these patients.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00798 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ACVR1 antibody can be used for detection of ACVR1 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ACVR1 in A549 cell lysate with ACVR1 antibody at (A) 1 and (B) 2 μg/mL.
Specific Publications For Anti-Activin receptor type-1 ACVR1 Antibody (A00798)
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