Product Info Summary
SKU: | A00798-3 |
---|---|
Size: | 80 µl |
Reactive Species: | Human, Rat |
Host: | Rabbit |
Application: | IHC-P, WB |
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Product info
Product Name
Anti-Activin Receptor Type IA (ACVR1) Antibody (N-term)
View all Activin RIA/ALK-2/Activin Receptor Type 1 Antibodies
SKU/Catalog Number
A00798-3
Size
80 µl
Description
Boster Bio Anti-Activin Receptor Type IA (ACVR1) Antibody (N-term) (Catalog # A00798-3). Tested in WB, IHC-P application(s). This antibody reacts with Human, Rat.
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Cite This Product
Anti-Activin Receptor Type IA (ACVR1) Antibody (N-term) (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00798-3)
Host
Rabbit
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
This Activin Receptor Type IA (ACVR1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human Activin Receptor Type IA (ACVR1).
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A00798-3 is reactive to ACVR1 in Human, Rat
Applications
A00798-3 is guaranteed for IHC-P, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
57.153kDa
Background of Activin RIA/ALK-2/Activin Receptor Type 1
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is an activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000
IHC-P: 1:50-1:100
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of lysates from A549,HepG2 cell line and rat testis tissue (from left to right),using ACVR1 Antibody (N-term).A00798-3 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
Click image to see more details
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma;
Protein Target Info & Infographic
Gene/Protein Information For ACVR1 (Source: Uniprot.org, NCBI)
Gene Name
ACVR1
Full Name
Activin receptor type-1
Weight
57.153kDa
Superfamily
protein kinase superfamily
Alternative Names
activin A receptor, type I; Activin RIA; ActivinRIA; ACTRI; ACVR1; ACVR1A; ACVRLK2; ALK2; ALK-2; FOP; SKR1; TSRI ACVR1 ACTRIA, ACVRLK2, ALK2, FOP, SKR1, TSRI, ACVR1 activin A receptor type 1 activin receptor type-1|TGF-B superfamily receptor type I|activin A receptor, type I|activin A receptor, type II-like kinase 2|activin receptor type I|activin receptor-like kinase 2|hydroxyalkyl-protein kinase|serine/threonine-protein kinase receptor R1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ACVR1, check out the ACVR1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ACVR1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Activin Receptor Type IA (ACVR1) Antibody (N-term) (A00798-3)
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No publications found for A00798-3
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