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Product Info Summary
| SKU: | A03149-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-B- and T-lymphocyte attenuator BTLA Antibody
SKU/Catalog Number
A03149-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-B- and T-lymphocyte attenuator BTLA Antibody (Catalog # A03149-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
BTLA antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-B- and T-lymphocyte attenuator BTLA Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03149-1)
Host
Rabbit
Contents
BTLA Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
BTLA antibody was raised against a 17 amino acid peptide near the center of human BTLA. The immunogen is located within amino acids 170 - 220 of BTLA .
Cross-reactivity
BTLA antibody is human specific. At least two isoforms of BTLA are known to exist.
Reactive Species
A03149-1 is reactive to BTLA in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
32.8 kDa
Background of BTLA
The B- and T-lymphocyte attenuator (BTLA) protein is a member of the immunoglobulin superfamily containing a single immunoglobulin (Ig) domain (1). Like other coihibitory receptors such as CTLA-4 and PD-1, BTLA functions as a receptor that relays inhibitory signals to suppress the immune response, and can inhibit LPS-induced endotoxic shock by suppressing TLR4 signaling in innate immune cells (1,2). Polymorphisms in this gene have also been associated with an increased risk of rheumatoid arthritis (3).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03149-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
BTLA antibody can be used for detection of BTLA by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of BTLA in Jurkat cell lysate at (A) 1 and (B) 2 μg/ml.
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Immunohistochemistry of BTLA in human small intestine tissue with BTLA antibody at 2.5 μg/mL.
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Immunofluorescence of BTLA in human small intestine tissue with BTLA antibody at 20 μg/mL.
Specific Publications For Anti-B- and T-lymphocyte attenuator BTLA Antibody (A03149-1)
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