Anti-Caspase-6 (phospho-S257) CASP6 Antibody

Caspase-6 antibody

Boster Bio Anti-Caspase-6 (phospho-S257) CASP6 Antibody catalog # A02631S257. Tested in IHC applications. This antibody reacts with Human,Mouse,Rat.

Product Info Summary

SKU: A02631S257
Size: 100ul
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC

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Product Name

Anti-Caspase-6 (phospho-S257) CASP6 Antibody

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SKU/Catalog Number

A02631S257

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Caspase-6 (phospho-S257) CASP6 Antibody catalog # A02631S257. Tested in IHC applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Caspase-6 (phospho-S257) CASP6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02631S257)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

Antiserum

Immunogen

Anti-Myosin-6 was prepared from whole rabbit serum produced by repeated immunizations with full length myosin-6 construct expressed in SF9 insect cells corresponding to porcine myosyn-6 protein.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02631S257 is reactive to CASP6 in Human, Mouse, Rat

Applications

A02631S257 is guaranteed for IHC Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

33.31kDa

Background of Caspase-6

Myosin VI is a myosin superfamily member with unique and intriguing features that allow it to fill a still-expanding number of cell biological roles. This actin-based motor produces force that acts towards the minus end of actin filaments, which is the opposite direction to all other characterized myosins. In mammalian cells, myosin VI is localized to endocytic vesicles, membrane ruffles, the cytosol and the Golgi complex. Its motor function is essential for several physiological functions of the cell, including normal rates of endocytosis, maintenance of Golgi morphology and protein secretion. Myosin VI regulates epithelial cell migration and plays a role in the maintenance of adhesive cellular contacts within epithelial cell layers. It is highly expressed in ovarian cancers and prostate cancers and its expression level, which is upregulated by DNA damage in a p53-dependent manner, correlates with the potential of the tumor to disseminate. More recently, myosin VI has been found involved in EGFR endocytosis through a clathrin dependent mechanism.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

IHC: 1:50-1:200

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For CASP6 (Source: Uniprot.org, NCBI)

Gene Name

CASP6

Full Name

Caspase-6

Weight

33.31kDa

Superfamily

peptidase C14A family

Alternative Names

Apoptotic protease Mch-2; CASP6; CASP-6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase6; Caspase-6; EC 3.4.22; Mch2; MCH2EC 3.4.22.59 CASP6 MCH2 caspase 6 caspase-6|apoptotic protease MCH-2|caspase 6, apoptosis-related cysteine peptidase|caspase 6, apoptosis-related cysteine protease

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CASP6, check out the CASP6 Infographic

CASP6 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CASP6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A02631S257-100ul

100ul

$482

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