Rabbit IgG polyclonal antibody for Caspase-6(CASP6) detection. Tested with WB, IHC-P in Human.
Anti-Caspase-6(P18)/CASP6 Antibody Info At A Glance
|Product Name||Anti-Caspase-6(P18)/CASP6 Antibody
See all Caspase-6 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for CASPASE 6/CASP6 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. CASPASE 6/CASP6 information: Molecular Weight: 33310 MW; Subcellular Localization: Cytoplasm.|
|Cite This Product||Anti-Caspase-6(P18)/CASP6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1441)|
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|Anti-Caspase-6(P18)/CASP6 Antibody may replace the following items: sc 28685|sc 836|sc 835|sc 74442|sc 836 X|sc 28685 X|sc 835 X|sc 74442 X|sc 835 G|sc 101806|sc 11761|sc 11761 R|sc 11761 X|sc 12893|sc 12893 R|sc 1656|sc 1656 X|sc 28685|sc 28685 X|sc 292905|sc 377069|sc 385517|sc 385517 X|sc 74442|sc 74442 X|sc 81524|sc 835|sc 835 G|sc 835 X|sc 836|sc 836 X.|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-6(P18)(24-44aa AFYKREMFDPAEKYKMDHRRR).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For CASP6 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||839|
|Species Of This Entry||Human|
|Superfamily||peptidase C14A family|
|Alternative Names||Caspase-6|Apoptotic protease Mch-2; CASP6; CASP-6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase6; Caspase-6; EC 3.4.22; Mch2; MCH2EC 184.108.40.206|
|Post Tranlational Modifications||Cleavage; Phosphorylation; Glycosylation; Deacetylation; Acetylation; Methylation; Dephosphorylation; Oxidation; Deglycosylation; Ubiquitination|
|Gene Location||4q25, on Chromasome 4, gene sequence: NC_000004.12 (109688628..109703445, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For CASP6 (Source: Uniprot.org, NCBI)
|Protein Function||Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.|
|Interacting Proteins||CASP3; SATB1|
|Research Areas||Apoptosis; Cancer; Caspases|
|Related Diseases||Neoplasms; Malignant Neoplasms; Alzheimer's Disease; Carcinoma; Leukemia; Huntington Disease; Malignant Neoplasm Of Breast; Malignant Paraganglionic Neoplasm; Nerve Degeneration; Neurodegenerative Disorders; Mammary Neoplasms; Tissue Adhesions; Glioma; Stomach Neoplasms; Neoplasm Metastasis; Neurofibrillary Tangles; Colonic Neoplasms; Lung Neoplasms; Melanoma; Adenocarcinoma|
|Related Pathways||Cell Death; Proteolysis; Pathogenesis; Localization; Induction Of Apoptosis; Programmed Cell Death; Cell Cycle; Apoptotic Process; Cell Proliferation; Cell Differentiation; Translation; Neuroprotection; Cellular Homeostasis; Reverse Transcription; Cell Growth; Cell Adhesion; Dna Damage Checkpoint; Glycosylation; Dna Repair; Protein Folding|
|Background||Caspase 6 is an enzyme that in humans is encoded by the caspase 6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease(caspase) family. Using radiation hybrid mapping, the Caspase 6 gene is localized to human chromosome 4q25-q26. Caspase 6 functions as a downstream enzyme in the caspase activation cascade. And Caspase 6 can cleave lamin A to its signature apoptotic fragment.|
|Scientific References||PMID: 7796396 by Fernandes-Alnemri T., et al. Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.|
PMID: 8900201 by Srinivasula S.M., et al. The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.
Our Boster Quality Guarantee for Anti-Caspase-6(P18)/CASP6 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
IHC(P): Human Mammary Cancer Tissue
Lane 1: MCF-7 Cell Lysate
Lane 2: HELA Cell Lysate
Lane 3: JURKAT Cell Lysate
Lane 4: CEM Cell Lysate
Lane 5: SW620 Cell Lysate
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
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- Flow Cytometry Technical Resource Center
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Note: sample size takes longer to process, average 5-7 days.
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