Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 5(CD40) detection. Tested with WB in Mouse. Cited in 2 publication(s).
Anti-CD40 Antibody Info At A Glance
|Product Name||Anti-CD40 Antibody
See all CD40/TNFRSF5 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for TNFRSF5/CD40 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Mouse. TNFRSF5/CD40 information: Molecular Weight: 32093 MW; Subcellular Localization: Isoform I: Cell membrane; Single-pass type I membrane protein.|
|Cite This Product||Anti-CD40 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1019)|
|Similar Products From
|Anti-CD40 Antibody may replace the following items: sc 30685|sc 1731|sc 30681|sc 974|sc 13528|sc 9096|sc 13128|sc 30683|sc 65264|sc 975|sc 65263|sc 30684|sc 20010|sc 59047|sc 514493.|
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of mouse CD40(22-36aa, QCVTCSDKQYLHDGQ).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For Cd40 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||21939|
|Species Of This Entry||Mouse|
|Protein Name||Tumor necrosis factor receptor superfamily member 5|
|Alternative Names||CD40/TNFRSF5|B cell surface antigen CD40; B-cell surface antigen CD40; Bp50B cell-associated molecule; CD40 antigen; CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CD40; CD40L receptor; CDw40; MGC9013; nerve growth factor receptor-related B-lymphocyte activation molecule; p50; TNFRSF5; TNFRSF5CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5|
|Post Tranlational Modifications||Phosphorylation; Cleavage; Methylation; Acetylation; Glycosylation; Dephosphorylation; Phosphorothioation; Biotinylation; Ubiquitination; Reduction; Oxidation; Nitration; Demethylation; Myristoylation; Acylation; Ribosylation; Palmitoylation; Nitrosylation; Carboxylation; Deamination|
|Gene Location||2 H3|2 85.38 cM, on Chromasome 2, gene sequence:|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For Cd40 (Source: Uniprot.org, NCBI)
|Protein Function||Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.|
|Research Areas||Adaptive Immunity; Apoptosis; Asthma; Cancer; Hematopoietic Stem Cell Markers; Immunology; Signal Transduction; Stem Cell Markers|
|Related Diseases||Neoplasms; Inflammation; Malignant Neoplasms; Autoimmune Reaction; Tissue Adhesions; Lymphoma; Autoimmune Diseases; Leukemia; Immunologic Deficiency Syndromes; B-cell Lymphomas; Carcinoma; Autoimmunity; Malignant Paraganglionic Neoplasm; Infective Disorder; Decreased Immunologic Activity [pe]; Atherosclerosis; Arthritis; Lymphoid Leukemia; Chronic Lymphocytic Leukemia; Rheumatoid Arthritis|
|Related Pathways||Secretion; Immune Response; Cell Activation; Cell Proliferation; Pathogenesis; Cytokine Production; Cell Death; Cell Differentiation; T Cell Proliferation; Cell Cycle; T Cell Activation; B Cell Activation; Cell Growth; B Cell Proliferation; Isotype Switching; Cell Maturation; Inflammatory Response; Cytokine Secretion; Sensitization; Cell Adhesion|
|Background||CD40 is a cell surface receptor that is expressed on the surface of all mature B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor(TNF) receptor superfamily and is the receptor for CD40 ligand. CD40 ligand(CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.|
|Scientific References||PMID: 1370315 by Torres R.M., et al. Differential increase of an alternatively polyadenylated mRNA species of murine CD40 upon B lymphocyte activation.|
PMID: 1281194 by Grimaldi J.C., et al. Genomic structure and chromosomal mapping of the murine CD40 gene.
Our Boster Quality Guarantee for Anti-CD40 Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: Recombinant Mouse CD 40 Protein 10ng
Lane 2: Recombinant Mouse CD 40 Protein 5ng
Lane 3: Recombinant Mouse CD 40 Protein 2.5ng
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
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Total number of citations: 2
|Peng Yd, Cheng Lx, Zeng Qt, Shi Y, Bao Xx, Mao Xb, Ji Qw, Li Sn, Guo M, Liang Zs, Wu Tc. Cell Biol Int. 2010 Mar 24;34(5):447-53. Doi: 10.1042/Cbi20090301. The Role Of Rantes As A Crucial Downstream Cytokine In Calcineurin-Dependent Vsmc Apoptosis...||PubMed ID 20132097|
|Meng Hx, Li Hn, Geng Js, Ohe R, Yu Xy, E Xq, Ye F, Yang Sr, Kato T, Zhang L, Ishida A, Ohta N, Jin Xm, Kakehata S, Geng Js, Yamakawa M. Transl Res. 2015 Sep;166(3):281-91. Doi: 10.1016/J.Trsl.2015.04.004. Epub 2015 Apr 17. Decreased Expression Of ...||PubMed ID 25953661|
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Note: sample size takes longer to process, average 5-7 days.
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