Product Info Summary
SKU: | A00028 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-CFTR Antibody
SKU/Catalog Number
A00028
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CFTR Antibody (Catalog # A00028). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CFTR antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-CFTR Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00028)
Host
Rabbit
Contents
CFTR Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
SK7
Isotype
IgG
Immunogen
CFTR antibody was raised against an 18 amino acid peptide near the carboxy terminus of human CFTR. The immunogen is located within amino acids 1290 - 1340 of CFTR.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
CFTR antibody is human, mouse and rat reactive.
Reactive Species
A00028 is reactive to CFTR in Human, Mouse, Rat
Applications
A00028 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
168.142kDa
Background of CFTR
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a member of the ATP-binding cassette (ABC) transporter superfamily, and a member of the MRP subfamily that is involved in multi-drug resistance (1,2). CFTR functions as a chloride channel and controls the regulation of other transport pathways (3). Mutations in this gene are associated with the autosomal recessive disorder cystic fibrosis, the most common, fatal, inherited disease of caucasian populations (1).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CFTR antibody can be used for detection of CFTR by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of CFTR in human small intestine tissue lysate with CFTR antibody at 1 μg/ml.
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Immunohistochemistry of CFTR in human small intestine tissue with CFTR antibody at 5 μg/mL.
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Immunofluorescence of CFTR in human small intestine tissue with CFTR antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CFTR (Source: Uniprot.org, NCBI)
Gene Name
CFTR
Full Name
Cystic fibrosis transmembrane conductance regulator
Weight
168.142kDa
Superfamily
ABC transporter superfamily
Alternative Names
ABC35; ABCC7CF; ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; cAMP-dependent chloride channel; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator (ATP-binding cassettesub-family C, member 7); cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator, ATP-binding cassette(sub-family C, member 7); dJ760C5.1; EC 3.6.3; MRP7EC 3.6.3.49; TNR-CFTR CFTR ABC35, ABCC7, CF/MRP, MRP7, TNR-CFTR, dJ760C5.1, CFTR CF transmembrane conductance regulator cystic fibrosis transmembrane conductance regulator|cAMP-dependent chloride channel|channel conductance-controlling ATPase|cystic fibrosis transmembrane conductance regulating|cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CFTR, check out the CFTR Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CFTR: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CFTR Antibody (A00028)
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No publications found for A00028
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