Cystic fibrosis transmembrane conductance regulator (CFTR)

Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). The ion channel is also permeable to HCO(3-); selectivity depends upon the extracellular chloride concentration (PubMed:15010471, PubMed:19019741).

Exerts its role also by regulating the action of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428).