Product Info Summary
SKU: | A05399 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | IHC |
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Product info
Product Name
Anti-CRSP77 (V171) MED17 Antibody
SKU/Catalog Number
A05399
Size
100ul
Form
Liquid
Description
Boster Bio Anti-CRSP77 (V171) MED17 Antibody catalog # A05399. Tested in IHC applications. This antibody reacts with Human,Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-CRSP77 (V171) MED17 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05399)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human TBX6 protein.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A05399 is reactive to MED17 in Human, Mouse
Applications
A05399 is guaranteed for IHC Boster Guarantee
Observed Molecular Weight
111 kDa
Calculated molecular weight
72.89kDa
Background of MED17
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
Beebe S.J., Mol. Endocrinol. 4:465-475(1990).
Gregory S.G., Nature 441:315-321(2006).
Wu K.-J., Oncogene 21:7872-7882(2002).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC: 1:50-1:200
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunohistochemistry validation of MED17 using Anti-CRSP77 (V171) MED17 Antibody (A05399).
Immunohistochemistry (IHC) analyzes of CRSP77 (V171) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.For more protocol information of IHC
Protein Target Info & Infographic
Gene/Protein Information For MED17 (Source: Uniprot.org, NCBI)
Gene Name
MED17
Full Name
Mediator of RNA polymerase II transcription subunit 17
Weight
72.89kDa
Superfamily
Mediator complex subunit 17 family
Alternative Names
Activator-recruited cofactor 77 kDa component; Cofactor required for Sp1 transcriptional activation subunit 6; cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa; CRSP6FLJ10812; CRSP77cofactor required for Sp1 transcriptional activation, subunit 6 (77kD); DRIP77; DRIP80ARC77; mediator complex subunit 17Vitamin D3 receptor-interacting protein complex 80 kDa component; mediator of RNA polymerase II transcription subunit 17; Thyroid hormone receptor-associated protein complex 80 kDa component; Transcriptional coactivator CRSP77; Trap80; TRAP80CRSP complex subunit 6 MED17 CRSP6, CRSP77, DRIP80, SRB4, TRAP80 mediator complex subunit 17 mediator of RNA polymerase II transcription subunit 17|ARC77|CRSP complex subunit 6|activator-recruited cofactor 77 kDa component|cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa|epididymis secretory sperm binding protein|thyroid hormone receptor-associated protein complex 80 kDa component|transcriptional coactivator CRSP77|vitamin D3 receptor-interacting protein complex 80 kDa component
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MED17, check out the MED17 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MED17: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CRSP77 (V171) MED17 Antibody (A05399)
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No publications found for A05399
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