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Product Info Summary
| SKU: | A04348 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-DR6 TNFRSF21 Antibody
SKU/Catalog Number
A04348
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-DR6 TNFRSF21 Antibody (Catalog # A04348). Tested in ELISA, WB applications. This antibody reacts with Human.
Storage & Handling
DR6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-DR6 TNFRSF21 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04348)
Host
Rabbit
Contents
DR6 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
DR6 antibody was raised against a 15 amino acid peptide near the amino terminus of human DR6. The immunogen is located within amino acids 30 - 80 of DR6.
Reactive Species
A04348 is reactive to TNFRSF21 in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
71.8 kDa
Background of TNFRSF21
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04348 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
DR6 antibody can be used for detection of DR6 by Western blot at 1:500 dilution. An approximately 68 kDa band can be detected.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. A04348P) with DR6 antibody at 1:500 dilution.
Specific Publications For Anti-DR6 TNFRSF21 Antibody (A04348)
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