Rabbit IgG polyclonal antibody for Mas-related G-protein coupled receptor member X1(MRGPRX1) detection. Tested with WB, IHC-P in Rat.
Anti-MRGX1/MRGPRX1 Antibody Info At A Glance
Polymerase (DNA Directed), Epsilon 3, also know as POLE3, is a histone-fold protein which interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers merge into larger enzymatic complexes for DNA transcription, replication, and packaging.
|Product Name||Anti-MRGX1/MRGPRX1 Antibody
See all MRGX1 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for MRGX1/MRGPRX1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Rat. MRGX1/MRGPRX1 information: Molecular Weight: 37074 MW; Subcellular Localization: Cell membrane; Multi-pass membrane protein; Tissue Specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. Associated preferentially with IB4 class of small-diameter somatosensory afferents (also known as nociceptors).|
|Cite This Product||Anti-MRGX1/MRGPRX1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1208)|
|Similar Products From
|Anti-MRGX1/MRGPRX1 Antibody may replace the following items: sc 7910|sc 1884|sc 4572|sc 13123|sc 1359|sc 55520|sc 13123|sc 1359|sc 1884|sc 4572|sc 55520|sc 7910.|
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of rat MRGX1(14-28aa TLNKTGHPSCRPILT).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For Mrgprx1 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||282547|
|Species Of This Entry||Rat|
|Protein Name||Mas-related G-protein coupled receptor member X1|
|Superfamily||G-protein coupled receptor 1 family|
|Alternative Names||MRGX1|G protein-coupled receptor MRGX1; GPCR; MAS-related GPR, member X1; mas-related G-protein coupled receptor member X1; MRGX1; MRGX1G protein-coupled receptor SNSR3; Sensory neuron-specific G-protein coupled receptor 3/4; SNSR3; SNSR4|
|Post Tranlational Modifications||Cleavage|
|Gene Location||1q22, on Chromasome 1, gene sequence:|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For Mrgprx1 (Source: Uniprot.org, NCBI)
|Protein Function||Orphan receptor activated by neuropeptides terminating in Arg-Phe or Arg-Phe-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception (By similarity).|
|Tissue Specificity||Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. Associated preferentially with IB4 class of small-diameter somatosensory afferents (also known as nociceptors).|
|Related Diseases||Pruritus; Disease Of Adrenal Medulla; Hyperalgesia; Welts; Pain; Dysesthesia|
|Background||MAS-related G-protein coupled receptor, member C, also known as MRGPRC or MRGPRX1, is a human gene. The Mas-related genes(Mrgs) comprise a family of >50 G protein-coupled receptors(GPCRs), many of which are expressed in specific subsets of nociceptive sensory neurons in mice. In contrast, humans contain a related but nonorthologous family of genes, called MrgXs or sensory neuron-specific receptors, of which many fewer appear to be expressed in sensory neurons.|
|Scientific References||PMID: 11850634 by Lembo P.M.C., et al. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs.|
PMID: 12909716 by Zylka M.J., et al. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.
Our Boster Quality Guarantee for Anti-MRGX1/MRGPRX1 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Rat
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: Marker
Lane 2: Rat Heart Tissue Lysate
Lane 3: Rat Skeletal Muscle Tissue Lysate
Lane 4: MCF-7 Cell Lysate
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
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- Flow Cytometry Technical Resource Center
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