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- Table of Contents
PDGFRB Antibodies
AND PDGFRB ELISA kits, PDGFRB Proteins
Many biological assays use antibodies to detect PDGFRB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDGFRB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDGFRB antibodies...
Designing an IHC experiment for PDGFRB? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PDGFRB IHC GuidePDGFRB Infographic by Boster Bio
All PDGFRB Products
Product
Figures
Specificity
Applications
Price
Anti-Tau/MAPT Antibody Picoband®
6 Citations
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A00097-3
100 μg/vial
Cat # A00097-3
100 μg/vial
Human
WB
$370
Cat # M00096Y1009
100 µl/vial
Cat # M00096Y1009
100 µl/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00096-1
100 μg/vial
Cat # A00096-1
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00096-6
20μL, 40μL, 100μL, 200μL
Cat # M00096-6
20μL, 40μL, 100μL, 200μL
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00096-5
100 μg
Cat # M00096-5
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00096-4
100 μg
Cat # M00096-4
100 μg
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M00096-1
100 μl
Cat # M00096-1
100 μl
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00096-7
100 μl/vial
Cat # M00096-7
100 μl/vial
Mouse, Rat
IF, ICC, WB
$370
Cat # P00096
100 μl
Cat # P00096
100 μl
Mouse
WB
$370
Cat # M00096Y1021
100 µl/vial
Cat # M00096Y1021
100 µl/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2268
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2268
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1448
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1448
1 kit, containing one 96-well plate and all necessary reagents
Human
$628
Cat # LS005159
20 µg, 100 µg
Cat # LS005159
20 µg, 100 µg
PDGFRB Overview
Facts about Platelet-derived growth factor receptor beta.
Platelet-derived growth factor receptor beta (PDGFRB)
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays a vital role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an important role in blood vessel growth by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells into endothelial cells.
Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury websites. Required for normal development of the cardiovascular system.
Gene Information
| Human | |
|---|---|
| Gene Name: | PDGFRB |
| Uniprot: | P09619 |
| Entrez: | 5159 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b antigen; CD140b; EC 2.7.10; EC 2.7.10.1; JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; PDGF-R-beta; platelet-derived growth factor receptor, beta polypeptide
Molecular Weight
Mass (kDA):
123.968 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q32 |
| Sequence: | 5; NC_000005.10 (150113839..150155845, complement) |
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
Diseases
- Neoplasms
- Leukemia
- Myeloproliferative Disease
- Malignant Neoplasms
- Eosinophilia
- Myeloid Leukemia
- Myeloid Leukemia, Chronic
- Chromosomal Translocation
- Hypereosinophilic Syndrome
- Eosinophilic Leukemia
- Chronic Eosinophilic Leukemia
- Idiopathic Hypereosinophilic Syndrome
- Mastocytosis
Interacting Proteins
- FYN
- GRB7
- IL1R1
- KDR
- Kdr
- KLHL12
- LRP6
- PDGFB
- PDGFRA
- PIK3R1
Pathways
- Pathogenesis
- Angiogenesis
- Cell Growth
- Cell Proliferation
- Reverse Transcription
- Cell Cycle
- Cell Adhesion
- Interphase
- Localization
- Regeneration
- Oncogenesis
- Cell Migration
- Vasculogenesis
PTMs
- Phosphorylation
- Methylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDGFRB
bosterbio.com/bosterbio-gene-info-cards/PDGFRB
References
PMID: 2835772 by Gronwald R.G.K., et al. Cloning and expression of a cDNA coding for the human platelet- derived growth factor receptor: evidence for more than one receptor class.
PMID: 2850496 by Claesson-Welsh L., et al. cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.
8 Publications of Boster PDGFRB Antibodies & ELISA Kits
- PubMed ID: PMID:28975979, GLI2 induces PDGFRB expression and modulates cancer stem cell properties of gast...
- PubMed ID: 10.1111/j.1478-3231.2008.01759.x, RNA interference targeting the platelet‐derived growth factor receptor β subu...
- PubMed ID: 10.1080/1028602042000325609, Effects of isoliensinine on angiotensin II-induced proliferation of porcine coro...
- PubMed ID: 10.1007/s00277-008-0470-3, Simultaneous expression of Oct4 and genes of three germ layers in single cell-de...
- PubMed ID: 18466260, RNA interference targeting the platelet-derived growth factor receptor ? subunit...
- PubMed ID: 24137287, Li R, Dai G, Zhao M, Zhang Y, Hui L, Zhang X, Jin B. Exp Ther Med. 2013 Oct;6(4)...
- PubMed ID: 25317137, Li X, Li M, Li Y, Quan Q, Wang J. Neural Regen Res. 2012 Dec 25;7(36):2860-6. Do...
- PubMed ID: 22793989, Li L, Ren L, Liu W, Wang Jc, Wang Y, Tu Q, Xu J, Liu R, Zhang Y, Yuan Ms, Li T, ...
*More publications can be found for each product on its corresponding product page