Anti-SHANK3 Antibody

SHANK3 antibody

Boster Bio Anti-SHANK3 Antibody (Catalog # A01231). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse. Cited in 1 publication(s).

Product Info Summary

SKU: A01231
Size: 0.1 mg
Reactive Species: Human, Mouse
Host: Rabbit
Application: ELISA, IF, IHC-P, WB

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Product Name

Anti-SHANK3 Antibody

View all SHANK3 Antibodies

SKU/Catalog Number

A01231

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-SHANK3 Antibody (Catalog # A01231). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Storage & Handling

SHANK3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-SHANK3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01231)

Host

Rabbit

Contents

SHANK3 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

SHANK3 antibody was raised against a 19 amino acid synthetic peptide near the center of human SHANK3. The immunogen is located within amino acids 890 - 940 of SHANK3.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

At least three alternatively spliced transcript isoforms of SHANK3 are known to exist.

Reactive Species

A01231 is reactive to SHANK3 in Human, Mouse

Applications

A01231 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Background of SHANK3

SH3 and multiple ankyrin repeat domains 3 (SHANK3), a member of the Shank gene family, plays a role in synapse formation and dendritic spine maturation. Shank proteins (Shank 1-3) containing PDZ domains are scaffold proteins of the postsynaptic density (PSD) that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder (ASD) and the neurological symptoms of 22q13.3 deletion syndrome.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

SHANK3 antibody can be used for detection of SHANK3 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL. Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Validation Images & Assay Conditions

Gene/Protein Information For SHANK3 (Source: Uniprot.org, NCBI)

Uniprot ID

Q9BYB0

Gene ID

85358

Gene Name

SHANK3

Full Name

SH3 and multiple ankyrin repeat domains protein 3

Weight

184.667kDa

Alternative Names

DEL22q13.3; KIAA1650proline rich synapse associated protein 2; Proline-rich synapse-associated protein 2; prosap2; PSAP2SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains 3; shank postsynaptic density protein; Shank3; SPANK-2 SHANK3 DEL22q13.3, PROSAP2, PSAP2, SCZD15, SPANK-2 SH3 and multiple ankyrin repeat domains 3 SH3 and multiple ankyrin repeat domains protein 3|proline rich synapse associated protein 2|shank postsynaptic density protein|shank3 postsynaptic density protein

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on SHANK3, check out the SHANK3 Infographic

SHANK3 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for SHANK3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected]

A01231 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Expression of SHANK3 in the Temporal Neocortex of Patients with Intractable Temporal Epilepsy and Epilepsy Rat Models

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Size

Total: $404

SKU:A01231

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A01231
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$404.00

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