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- Table of Contents
Facts about SH3 and multiple ankyrin repeat domains protein 3.
Plays a role in the structural and functional organization of the dendritic spine and synaptic junction throughout the interaction with Arp2/3 and WAVE1 complex as well as the marketing of the F-actin clusters. Through this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling.
Mouse | |
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Gene Name: | Shank3 |
Uniprot: | Q4ACU6 |
Entrez: | 58234 |
Belongs to: |
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SHANK family |
DEL22q13.3; KIAA1650proline rich synapse associated protein 2; Proline-rich synapse-associated protein 2; prosap2; PSAP2SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains 3; shank postsynaptic density protein; Shank3; SPANK-2
Mass (kDA):
185.397 kDA
Mouse | |
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Location: | 15|15 E3 |
Sequence: | 15; |
In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum.
PMID: 16606358 by Uchino S., et al. Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain- containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy- 5-methyl-4-isoxazole propionic acid receptor.
PMID: 24164323 by Waga C., et al. Identification of two novel Shank3 transcripts in the developing mouse neocortex.
*More publications can be found for each product on its corresponding product page