SH3 and multiple ankyrin repeat domains protein 3 (Shank3)

Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors through complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton.

Plays a role in the structural and functional organization of the dendritic spine and synaptic junction throughout the interaction with Arp2/3 and WAVE1 complex as well as the marketing of the F-actin clusters. Through this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling.