Anti-TIM 1/HAVCR1 Antibody
Rabbit IgG polyclonal antibody for Hepatitis A virus cellular receptor 1(HAVCR1) detection. Tested with WB, IHC-P, ICC in Human.
Anti-TIM 1/HAVCR1 Antibody Info At A Glance
|Applications:||IHC, ICC, WB|
PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Cyclophilin-A is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. Cyclophilin-A can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.
|Product Name||Anti-TIM 1/HAVCR1 Antibody
See all TIM-1/KIM-1/HAVCR primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for KIM 1/HAVCR1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. KIM 1/HAVCR1 information: Molecular Weight: 38720 MW; Subcellular Localization: Membrane ; Single-pass type I membrane protein ; Tissue Specificity: Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.|
|Cite This Product||Anti-TIM 1/HAVCR1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1624)|
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|Anti-TIM 1/HAVCR1 Antibody may replace the following items: sc 12374|sc 367179|sc 393122|sc 393146|sc 8891.|
|Applications||IHC, ICC, WB
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P) and ICC.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human TIM 1(332-348aa IKALQNAVEKEVQAEDN).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For HAVCR1 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||26762|
|Species Of This Entry||Human|
|Protein Name||Hepatitis A virus cellular receptor 1|
|Alternative Names||TIM-1/KIM-1/HAVCR|CD365; HAVCR1; HAVCR-1; HAVCRT cell immunoglobin domain and mucin domain protein 1; hepatitis A virus cellular receptor 1; Kidney injury molecule 1; KIM1; KIM-1; T-cell immunoglobulin and mucin domain-containing protein 1; TIM1; TIM-1; TIM-1TIM; TIM1TIMD-1; TIMD1T-cell membrane protein 1|
|Post Tranlational Modifications||Phosphorylation; Glycosylation; Cleavage; Deacetylation; Acetylation; Methylation|
|Subcellular Localization||Membrane; Single-pass type I membrane protein.|
|Gene Location||5q33.3, on Chromasome 5, gene sequence: NC_000005.10 (157028383..157069633, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For HAVCR1 (Source: Uniprot.org, NCBI)
|Protein Function||May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.|
|Tissue Specificity||Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.|
|Related Diseases||Injury To Kidney; Acute Kidney Injury; Kidney Diseases; Hepatitis; Hepatitis A; Asthma; Inflammation; Kidney Failure, Chronic; Kidney Failure; Chronic Kidney Disease; Proteinuria Of Undiagnosed Cause; Autoimmune Reaction; Diabetic Nephropathy; Allergy; Ischemia; Diabetes Mellitus; Autoimmune Diseases; Fibrosis; Malignant Neoplasms|
|Related Pathways||Glomerular Filtration; Excretion; Pathogenesis; Cell Activation; Immune Response; Cytokine Production; T Cell Activation; Cell Proliferation; Cell Differentiation; T Cell Proliferation; Phagocytosis; Cell Death; Secretion; T Cell Differentiation; Cell Adhesion; Lymphocyte Proliferation; Regeneration; Dedifferentiation; Lymphocyte Activation; Programmed Cell Death|
|Background||KIM1(KIDNEY INJURY MOLECULE 1), also known as HAVCR1, HAVCR or TIM1, is a protein that in humans is encoded by the KIM1 gene. The KIM1 gene is mapped to 5q33.3. Biochemical, mutational, and cell adhesion analyses confirm that Tim1 is capable of homophilic Tim-Tim interactions. The features identified in murine KIM1 is conserved in human KIM1. The KIM1 protein is indeed a receptor for the virus through the infection of canine osteogenic sarcoma cells expressing HAVCR1 with HAV. Using a monoclonal antibody to mouse Tim1, Tim1 is expressed after activation of naive T cells and on T cells differentiated in Th2-polarizing conditions. Ectopic expression of KIM1 during mouse T-cell differentiation leads to production of the Th2-type cytokine Il4, but not the Th1-type cytokine Ifng. KIM1-expressing epithelial cells internalized apoptotic bodies, and Kim1 is directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and in porcine and canine epithelial cell lines.|
|Scientific References||PMID: 9658108 by Feigelstock D., et al. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor.|
PMID: 17229699 by Tami C., et al. Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions.
Our Boster Quality Guarantee for Anti-TIM 1/HAVCR1 Antibody covers its use in the following applications.Immunocytochemistry , 0.5-1μg/ml, Human, -
Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: SMMC Cell Lysate
Lane 2: HELA Cell Lysate
Lane 3: PANC Cell Lysate
Lane 4: M231 Cell Lysate
Lane 5: M453 Cell Lysate
IHC(P): Human Tonsil Tissue
ICC: K562 Cell
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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Note: sample size takes longer to process, average 5-7 days.
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