Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody
Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 2(TIMP2) detection. Tested with IHC-P, ELISA in Human;Mouse;Rat. Cited in 16 publication(s).
Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody
See all TIMP-2 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for TIMP 2/TIMP2 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: ELISA. Reactive species: Human. TIMP 2/TIMP2 information: Molecular Weight: 24399 MW; Subcellular Localization: Secreted.|
|Cite This Product||Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1076)|
|Similar Products From
|Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody may replace the following items: sc 374311|sc 10528|sc 374312.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP2(205-220aa RGAAPPKQEFLDIEDP), identical to the related mouse and rat sequences.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For TIMP2 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||7077|
|Species Of This Entry||Human|
|Protein Name||Metalloproteinase inhibitor 2|
|Superfamily||protease inhibitor I35 (TIMP) family|
|Alternative Names||TIMP-2|CSC-21Ktissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; TIMP metallopeptidase inhibitor 2; TIMP2; TIMP-2; Tissue inhibitor of metalloproteinases 2|
|Post Tranlational Modifications||Phosphorylation; Cleavage; Methylation; Demethylation; Reduction; Acetylation; Dephosphorylation; Oxidation; Ribosylation|
|Gene Location||17q25.3, on Chromasome 17, gene sequence: NC_000017.11 (78852977..78925387, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For TIMP2 (Source: Uniprot.org, NCBI)
|Protein Function||Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.|
|Interacting Proteins||MMP14; MMP2|
|Related Diseases||Neoplasms; Malignant Neoplasms; Cell Invasion; Neoplasm Metastasis; Carcinoma; Neoplasm Invasiveness; Fibrosis; Tumor Angiogenesis; Malignant Paraganglionic Neoplasm; Inflammation; Tissue Adhesions; Pathologic Neovascularization; Adenocarcinoma; Cardiovascular Diseases; Endometrial Polyp; Kidney Diseases; Lung Neoplasms; Malignant Neoplasm Of Breast; Liver Neoplasms|
|Related Pathways||Angiogenesis; Pathogenesis; Localization; Cell Migration; Cell Proliferation; Secretion; Tissue Remodeling; Proteolysis; Reverse Transcription; Cell Adhesion; Methylation; Cell Growth; Cell Motility; Dna Methylation; Wound Healing; Regeneration; Cell Cycle; Transport; Invasive Growth; Cell Death|
|Background||TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.|
|Scientific References||PMID: 2380196 by Stetler-Stevenson W.G., et al. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.|
PMID: 2157214 by Boone T.C., et al. cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.
Our Boster Quality Guarantee for Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
ELISA , 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
IHC(P): Human Mammary Cancer Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
Other Recommended Resources
Here are featured tools and databases that you might find useful.
Total number of citations: 16
|Zhang Jt, Fan Yz, Chen Cq, Zhao Zm, Sun W. Int J Oncol. 2012 May;40(5):1501-14. Doi: 10.3892/Ijo.2011.1314. Epub 2011 Dec 21. Norcantharidin: A Potential Antiangiogenic Agent For Gallbladder Cancers In Vitro And In Vivo.||PubMed ID 22200632|
|Xu Xl, Ling Dy, Zhu Qy, Fan Wj, Zhang W. Eur J Pharmacol. 2013 Jan 5;698(1-3):370-8. Doi: 10.1016/J.Ejphar.2012.11.019. Epub 2012 Nov 21. The Effect Of 2,3,4',5-Tetrahydroxystilbene-2-0-??-D Glucoside On Neointima Formation In A Rat Artery Balloon...||PubMed ID 23178522|
|Jiang S, Jin F, Li D, Zhang X, Yang Y, Yang D, Li K, Yang Y, Ma S. High Alt Med Biol. 2013 Jun;14(2):175-80. Doi: 10.1089/Ham.2012.1083. Intermittent Hypobaric Hypoxia Promotes Atherosclerotic Plaque Instability In Apoe-Deficient Mice.||PubMed ID 23795739|
|Jin F, Jiang S, Yang D, Zhang X, Yang Y, Zhang Y, Li K, Yang Y, Ma S. Biochem Biophys Res Commun. 2012 Nov 9;428(1):86-92. Doi: 10.1016/J.Bbrc.2012.10.011. Epub 2012 Oct 8. Acipimox Attenuates Atherosclerosis And Enhances Plaque Stability In Apoe-...||PubMed ID 23058919|
|Hu P, Wang J, Zhao Xq, Hu B, Lu L, Qin Yh. Mol Biol Rep. 2013 Feb;40(2):1429-41. Doi: 10.1007/S11033-012-2186-7. Epub 2012 Oct 17. Overexpressed C-Type Natriuretic Peptide Serves As An Early Compensatory Response To Counteract Extracellular Matrix...||PubMed ID 23073778|
|Shan A, Zhou C, He Y, Feng W, Chen G, Zhong G. Ren Fail. 2013;35(1):37-42. Doi: 10.3109/0886022X.2012.741645. Epub 2012 Nov 14. Expression Of Both Matrix Metalloproteinase-2 And Its Tissue Inhibitor-2 In Tunica Media Of Radial Artery In Uremic Pat...||PubMed ID 23151010|
|Qiu Lb, Zhou Y, Wang Q, Yang Ll, Liu Hq, Xu Sl, Qi Yh, Ding Gr, Guo Gz. Toxicology. 2011 Jul 11;285(1-2):31-8. Doi: 10.1016/J.Tox.2011.03.019. Epub 2011 Apr 8. Synthetic Gelatinases Inhibitor Attenuates Electromagnetic Pulse-Induced Blood-Brain Ba...||PubMed ID 21501651|
|Wu Ty, Zhang Th, Qu Lm, Feng Jp, Tian Ll, Zhang Bh, Li Dd, Sun Yn, Liu M. Int J Clin Exp Pathol. 2013 Dec 15;7(1):56-63. Ecollection 2014. Mir-19A Is Correlated With Prognosis And Apoptosis Of Laryngeal Squamous Cell Carcinoma By Regulating Timp-2...||PubMed ID 24427326|
|MMP-1/2 and TIMP-1/2 expression levels, and the levels of collagenous and elastic fibers correlate with disease progression in a hamster model of tongue cancer||PubMed ID 26870168|
|Inhibition of Zymosan-Induced Inflammatory Factors Expression by ATRA Nanostructured Lipid Carriers||PubMed ID 27340562|
|The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-?1 pathway||PubMed ID 27453531|
|Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway||PubMed ID 29393353|
|Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells||PubMed ID 20688607|
|Effect of Novel Gasotransmitter hydrogen sulfide on renal fibrosis and connexins expression in diabetic rats||PubMed ID 27575818|
|Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway.||PubMed ID 28260896|
|Inhibition of pulmonary adenoma in diethylnitrosamine-induced rats by Rhizoma paridis saponins||PubMed ID 26196122|
Order Product (PA1076)
Domestically in USA and Canada, ships next business day if available in stock.
Note: sample size takes longer to process, average 5-7 days.
All Boster antibodies and ELISA kits are guaranteed to meet the specifications on the data sheet.See Details
Download troubleshooting handbooks for IHC, Western blot and ELISA for FREE.Download Free PDFs Now
Guaranteed product quality
We promise all of our products perform as described in datasheets.