Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody

Product Name

Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody

View all TIMP2 Antibodies

SKU/Catalog Number

PA1076
BA0576 is an alternative SKU for this antibody, used in previous lots.

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody catalog # PA1076. Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.

TIMP2 is described as a tissue inhibitor of metalloproteinases (TIMP family) and noted as a metastasis suppressor; the page frames TIMP2 as a natural inhibitor of matrix metalloproteinases involved in extracellular matrix (ECM) degradation, with an additional role in directly suppressing endothelial cell proliferation—linking it to ECM remodeling and angiogenic control. Assay context: validated for ELISA and IHC. Often analyzed with ECM deposition/remodeling markers such as COL1A1 (pro-collagen Iα1) and FN1 (fibronectin), and can be contrasted with protease-side readouts (e.g., MMP12; study-dependent). For compartment-resolved ECM/IHC interpretation, multiplex IHC plus pathology review supports consistent scoring across regions of interest.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1076)

Host

Rabbit

Contents

Each vial contains antibody formulated with stabilizing components, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
*This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP2, identical to the related mouse and rat sequences.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1076 is reactive to TIMP2 in Human, Mouse, Rat

Calculated molecular weight

24.4 kDa

Background of TIMP2

TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA1076 is guaranteed for ELISA, IHC Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat
ELISA, 0.1-0.5μg/ml, -

Positive Control

IHC: Human Mammary Cancer Tissue

Validation Images & Assay Conditions

See full target information TIMP2

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