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- Table of Contents
TIMP2 antibody (PA1076) performs well in ELISA, IHC and shows reactivity with Human, Mouse, Rat.
- Validated for inter-lot consistency, specificity, and reproducibility
- Committed to quality since 1993
- Over 14 Publications
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Anti-TIMP2 antibody, PA1076, IHC(P)
IHC(P): Human Mammary Cancer Tissue
IHC(P): Human Mammary Cancer Tissue
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Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody
TIMP2 antibody
| Reactive Species | Host | Application |
|---|---|---|
| Human, Mouse, Rat | Rabbit | ELISA, IHC |
Tested Applications
TIMP2 antibody was positively detected by IHC in:
Human Mammary Cancer Tissue
Use TE buffer pH 9.0 for antigen retrieval; (*) citrate buffer pH 6.0 is an alternative.
Recommend Dilution
Application
Dilution
Species
Immunohistochemistry (Paraffin-embedded Section)
0.5-1μg/ml
Human, Mouse, Rat
ELISA
0.1-0.5μg/ml
-
* It is recommended to optimize the amount of this reagent in each experimental system to achieve the best results.
Reactive Data
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IHC
IF
ELISA
Human
Tested
Recommend
Recommend
Mouse
Recommend
Rat
Recommend
Rabbit
Predicted
Predicted
Predicted
Bovine
Predicted
Predicted
Predicted
Sheep
Predicted
Predicted
Predicted
Monkey
Predicted
Predicted
Predicted
Product Information
Product Name
Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody
View all TIMP2 Antibodies
View all TIMP2 Antibodies
Form
Lyophilized
Uniprot
Gene ID
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Host
Rabbit
Contents
Each vial contains antibody formulated with stabilizing components, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
*This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.
*This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP2, identical to the related mouse and rat sequences.
Cross-Reactivity
No cross-reactivity with other proteins
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Calculated Molecular Weight
24.4 kDa
Background of TIMP2
TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Cite This Product
Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1076)
Antibody Homology Across Species
The results generated by this homology analysis tool for commonly used animal species are shown below. For unlisted species, please refer to the homology analysis between the immunogen sequence and the corresponding species.
A homology of ≥90% is recommended. Generally, higher homology indicates a greater potential for cross-species reactivity. However, protein expression levels may vary among different species, tissues, and cell types. Therefore, the homology analysis results are for reference only and do not guarantee antibody cross-reactivity or experimental performance.
Human
100%
High Homology
Mouse
100%
High Homology
Rat
100%
High Homology
Rabbit
100%
High Homology
Cow
100%
High Homology
Sheep
100%
High Homology
Monkey
100%
High Homology
Zebrafish
75%
Moderate Homology
Drosophila
19%
Low homology
Homology ≥ 90%High Homology
70% ≤ Homology < 90%Moderate Homology
Homology < 70%Low homology
Protocols
Immunohistochemistry (IHC) protocol for TIMP2 antibody
Publications
Application:
Species:
Exogenous H2S mitigates myocardial fibrosis in diabetic rats through suppression of the canonical Wnt pathway
Published: 2019-06-10
Journal: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Application: WB
Impact Factor: 2.93
Species: Rat
PMID: 31198980
Human nail stem cells are retained but hypofunctional during aging
Published: 2018-04-09
Journal: JOURNAL OF MOLECULAR HISTOLOGY
Application: WB
Impact Factor: 2.41
Species: Rat
PMID: 29633149
Riboflavin and ultraviolet A irradiation for the prevention of progressive myopia in a guinea pig model
Published: 2017-08-31
Journal: EXPERIMENTAL EYE RESEARCH
Application: WB
Impact Factor: 3.33
Species: Pig
PMID: 28864176
Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway
Published: 2016-12-30
Journal: International Journal of Nanomedicine
Application: IHC
Impact Factor: 4.32
Species: Rat
PMID: 28115845
Lichong decoction reduces Matrix Metalloproteinases-2 expression but increases Tissue Inhibitors of Matrix Metalloproteinases-2 expression in a rat model of uterine leiomyoma
Published: 2016-09-16
Journal: Journal of Traditional Chinese Medicine
Application: IHC,WB
Impact Factor: 1.02
Species: Rat
PMID: 28459512
Over-Expression of Calpastatin Inhibits Calpain Activation and Attenuates Post-Infarction Myocardial Remodeling
Published: 2015-03-18
Journal: PLoS One
Application: WB
Impact Factor: 3.23
Species: Mouse
PMID: 25786109
Expression of Both Matrix Metalloproteinase-2 and Its Tissue Inhibitor-2 in Tunica Media of Radial Artery in Uremic Patients
Published: 2013-01-16
Journal: RENAL FAILURE
Application: IHC
Impact Factor: 0.94
Species: Human
PMID: 23151010
The effect of 2,3,4′,5-tetrahydroxystilbene-2-0-β-d glucoside on neointima formation in a rat artery balloon injury model and its possible mechanisms
Published: 2012-11-21
Journal: EUROPEAN JOURNAL OF PHARMACOLOGY
Impact Factor: 2.52
PMID: 23178522
Overexpressed C-type natriuretic peptide serves as an early compensatory response to counteract extracellular matrix remodeling in unilateral ureteral obstruction rats
Published: 2012-10-17
Journal: MOLECULAR BIOLOGY REPORTS
Application: IHC
Impact Factor: 2.93
Species: Rat
PMID: 23073778
Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet
Published: 2012-10-08
Journal: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Application: IHC
Impact Factor: 2.48
Species: Mouse
PMID: 23058919
Synthetic gelatinases inhibitor attenuates electromagnetic pulse-induced blood–brain barrier disruption by inhibiting gelatinases-mediated ZO-1 degradation in rats
Published: 2011-04-08
Journal: TOXICOLOGY
Application: WB,IHC
Impact Factor: 3.64
Species: Rat
PMID: 21501651
Antitumor and antimetastatic activities of Rhizoma Paridis saponins
Published: 2009-08-20
Journal: STEROIDS
Application: IHC
Impact Factor: 2.59
Species: Mouse
PMID: 19699217
Cyclophosphamide promotes pulmonary metastasis on mouse lung adenocarcinoma
Published: 2008-09-03
Journal: CLINICAL & EXPERIMENTAL METASTASIS
Application: IHC
Impact Factor: 2.51
Species: Mouse
PMID: 18766303
Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells
Published: 2005-04-28
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Application: IHC
Impact Factor: 0.00
Species: Human
PMID: 15832413
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Product Promise
We promise Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody performs excellently in relevant applications for ELISA, IHC. If it doesn't perform as promised, we will refund the product. Learn more
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PA1076
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00
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We promise all of our products perform as described in datasheets.
This product is for Research Use Only. Not for use in diagnostic procedures.
Update date:
Oct 4, 2026